The impact of statins and renin-angiotensin-aldosterone system blockers on pulmonary vein antrum isolation outcomes in post-menopausal females

Aims To assess whether treatment with statins or renin-angiotensin-aldosterone system (RAAS) inhibitors as potential procedural 'augmenting agents' improved atrial fibrillation (AF) catheter ablation recurrence rates in post-menopausal females (PMFS). Methods and results Five hundred and e...

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Veröffentlicht in:Europace (London, England) England), 2010-03, Vol.12 (3), p.322-330
Hauptverfasser: Patel, Dimpi, Mohanty, Prasant, Di Biase, Luigi, Wang, Yan, Shaheen, Mazen H., Sanchez, Javier E., Horton, Rodney P., Gallinghouse, G. Joseph, Zagrodzky, Jason D., Bailey, Shane M., Burkhardt, J. David, Lewis, William R., Diaz, Alberto, Beheiry, Salwa, Hongo, Richard, Al-Ahmad, Amin, Wang, Paul, Schweikert, Robert, Natale, Andrea
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container_end_page 330
container_issue 3
container_start_page 322
container_title Europace (London, England)
container_volume 12
creator Patel, Dimpi
Mohanty, Prasant
Di Biase, Luigi
Wang, Yan
Shaheen, Mazen H.
Sanchez, Javier E.
Horton, Rodney P.
Gallinghouse, G. Joseph
Zagrodzky, Jason D.
Bailey, Shane M.
Burkhardt, J. David
Lewis, William R.
Diaz, Alberto
Beheiry, Salwa
Hongo, Richard
Al-Ahmad, Amin
Wang, Paul
Schweikert, Robert
Natale, Andrea
description Aims To assess whether treatment with statins or renin-angiotensin-aldosterone system (RAAS) inhibitors as potential procedural 'augmenting agents' improved atrial fibrillation (AF) catheter ablation recurrence rates in post-menopausal females (PMFS). Methods and results Five hundred and eighteen consecutive female patients had undergone AF catheter ablation from January 2005 to May 2008. Post-menopausal females were selected and procedure outcomes were compared between cohorts of PMFS treated with statins or RAAS inhibitors to untreated PMFS. Out of 408 PMFS, 36 (8.8%) were treated with a combination of RAAS inhibitors and statins, thus were excluded leaving a total of 372 (91.2%) patients in the study. Out of 372 patients, 111 (29.8%) were on statins (Group 1), 59 (15.9%) on RAAS inhibitors (Group 2), and 202 (54.3%) without RAAS inhibitors or statins [(Group 3) control population]. Over a mean follow-up time of 24 ± 8.3 (median 25) months, 78 (70.6%) in Group 1, 38 (65.4%) in Group 2, and 139 (68.8%) in Group 3 had procedural success. Statin or RAAS inhibitor use did not predict lower recurrence rates [hazard ratio (HR): 1.26, P = 0.282 and HR: 1.14, P = 0.728, respectively]. When compared with controls, no difference in the cumulative incidence of recurrence was found with statin or RAAS inhibitors use (P = 0.385 and P = 0.761, respectively). Conclusion Treatment with statins or RAAS inhibitors did not improve catheter ablation success rates among PMFS. Thereby, from a clinical standpoint, PMFS should not be started on these treatments as a procedural 'augmenting agent' at this time.
doi_str_mv 10.1093/europace/eup387
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Joseph ; Zagrodzky, Jason D. ; Bailey, Shane M. ; Burkhardt, J. David ; Lewis, William R. ; Diaz, Alberto ; Beheiry, Salwa ; Hongo, Richard ; Al-Ahmad, Amin ; Wang, Paul ; Schweikert, Robert ; Natale, Andrea</creator><creatorcontrib>Patel, Dimpi ; Mohanty, Prasant ; Di Biase, Luigi ; Wang, Yan ; Shaheen, Mazen H. ; Sanchez, Javier E. ; Horton, Rodney P. ; Gallinghouse, G. Joseph ; Zagrodzky, Jason D. ; Bailey, Shane M. ; Burkhardt, J. David ; Lewis, William R. ; Diaz, Alberto ; Beheiry, Salwa ; Hongo, Richard ; Al-Ahmad, Amin ; Wang, Paul ; Schweikert, Robert ; Natale, Andrea</creatorcontrib><description>Aims To assess whether treatment with statins or renin-angiotensin-aldosterone system (RAAS) inhibitors as potential procedural 'augmenting agents' improved atrial fibrillation (AF) catheter ablation recurrence rates in post-menopausal females (PMFS). Methods and results Five hundred and eighteen consecutive female patients had undergone AF catheter ablation from January 2005 to May 2008. Post-menopausal females were selected and procedure outcomes were compared between cohorts of PMFS treated with statins or RAAS inhibitors to untreated PMFS. Out of 408 PMFS, 36 (8.8%) were treated with a combination of RAAS inhibitors and statins, thus were excluded leaving a total of 372 (91.2%) patients in the study. Out of 372 patients, 111 (29.8%) were on statins (Group 1), 59 (15.9%) on RAAS inhibitors (Group 2), and 202 (54.3%) without RAAS inhibitors or statins [(Group 3) control population]. Over a mean follow-up time of 24 ± 8.3 (median 25) months, 78 (70.6%) in Group 1, 38 (65.4%) in Group 2, and 139 (68.8%) in Group 3 had procedural success. Statin or RAAS inhibitor use did not predict lower recurrence rates [hazard ratio (HR): 1.26, P = 0.282 and HR: 1.14, P = 0.728, respectively]. When compared with controls, no difference in the cumulative incidence of recurrence was found with statin or RAAS inhibitors use (P = 0.385 and P = 0.761, respectively). Conclusion Treatment with statins or RAAS inhibitors did not improve catheter ablation success rates among PMFS. Thereby, from a clinical standpoint, PMFS should not be started on these treatments as a procedural 'augmenting agent' at this time.</description><identifier>ISSN: 1099-5129</identifier><identifier>EISSN: 1532-2092</identifier><identifier>DOI: 10.1093/europace/eup387</identifier><identifier>PMID: 20064822</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Aged ; Angiotensin II Type 1 Receptor Blockers - therapeutic use ; Atrial Fibrillation - drug therapy ; Atrial Fibrillation - epidemiology ; Atrial Fibrillation - surgery ; C-Reactive Protein - metabolism ; Catheter Ablation - methods ; Catheter Ablation - statistics &amp; numerical data ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Kaplan-Meier Estimate ; Middle Aged ; Postmenopause ; Postoperative Complications - epidemiology ; Postoperative Complications - prevention &amp; control ; Predictive Value of Tests ; Proportional Hazards Models ; Renin-Angiotensin System - drug effects ; Risk Factors ; Secondary Prevention ; Treatment Outcome</subject><ispartof>Europace (London, England), 2010-03, Vol.12 (3), p.322-330</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: journals.permissions@oxfordjournals.org. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-3101e2b77e81374da76ba68afeac6a8edf70cbe78d95e050168df21532ad1b203</citedby><cites>FETCH-LOGICAL-c438t-3101e2b77e81374da76ba68afeac6a8edf70cbe78d95e050168df21532ad1b203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1598,27901,27902</link.rule.ids><linktorsrc>$$Uhttps://dx.doi.org/10.1093/europace/eup387$$EView_record_in_Oxford_University_Press$$FView_record_in_$$GOxford_University_Press</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20064822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, Dimpi</creatorcontrib><creatorcontrib>Mohanty, Prasant</creatorcontrib><creatorcontrib>Di Biase, Luigi</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Shaheen, Mazen H.</creatorcontrib><creatorcontrib>Sanchez, Javier E.</creatorcontrib><creatorcontrib>Horton, Rodney P.</creatorcontrib><creatorcontrib>Gallinghouse, G. Joseph</creatorcontrib><creatorcontrib>Zagrodzky, Jason D.</creatorcontrib><creatorcontrib>Bailey, Shane M.</creatorcontrib><creatorcontrib>Burkhardt, J. David</creatorcontrib><creatorcontrib>Lewis, William R.</creatorcontrib><creatorcontrib>Diaz, Alberto</creatorcontrib><creatorcontrib>Beheiry, Salwa</creatorcontrib><creatorcontrib>Hongo, Richard</creatorcontrib><creatorcontrib>Al-Ahmad, Amin</creatorcontrib><creatorcontrib>Wang, Paul</creatorcontrib><creatorcontrib>Schweikert, Robert</creatorcontrib><creatorcontrib>Natale, Andrea</creatorcontrib><title>The impact of statins and renin-angiotensin-aldosterone system blockers on pulmonary vein antrum isolation outcomes in post-menopausal females</title><title>Europace (London, England)</title><addtitle>Europace</addtitle><description>Aims To assess whether treatment with statins or renin-angiotensin-aldosterone system (RAAS) inhibitors as potential procedural 'augmenting agents' improved atrial fibrillation (AF) catheter ablation recurrence rates in post-menopausal females (PMFS). Methods and results Five hundred and eighteen consecutive female patients had undergone AF catheter ablation from January 2005 to May 2008. Post-menopausal females were selected and procedure outcomes were compared between cohorts of PMFS treated with statins or RAAS inhibitors to untreated PMFS. Out of 408 PMFS, 36 (8.8%) were treated with a combination of RAAS inhibitors and statins, thus were excluded leaving a total of 372 (91.2%) patients in the study. Out of 372 patients, 111 (29.8%) were on statins (Group 1), 59 (15.9%) on RAAS inhibitors (Group 2), and 202 (54.3%) without RAAS inhibitors or statins [(Group 3) control population]. Over a mean follow-up time of 24 ± 8.3 (median 25) months, 78 (70.6%) in Group 1, 38 (65.4%) in Group 2, and 139 (68.8%) in Group 3 had procedural success. Statin or RAAS inhibitor use did not predict lower recurrence rates [hazard ratio (HR): 1.26, P = 0.282 and HR: 1.14, P = 0.728, respectively]. When compared with controls, no difference in the cumulative incidence of recurrence was found with statin or RAAS inhibitors use (P = 0.385 and P = 0.761, respectively). Conclusion Treatment with statins or RAAS inhibitors did not improve catheter ablation success rates among PMFS. Thereby, from a clinical standpoint, PMFS should not be started on these treatments as a procedural 'augmenting agent' at this time.</description><subject>Aged</subject><subject>Angiotensin II Type 1 Receptor Blockers - therapeutic use</subject><subject>Atrial Fibrillation - drug therapy</subject><subject>Atrial Fibrillation - epidemiology</subject><subject>Atrial Fibrillation - surgery</subject><subject>C-Reactive Protein - metabolism</subject><subject>Catheter Ablation - methods</subject><subject>Catheter Ablation - statistics &amp; numerical data</subject><subject>Combined Modality Therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Kaplan-Meier Estimate</subject><subject>Middle Aged</subject><subject>Postmenopause</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - prevention &amp; control</subject><subject>Predictive Value of Tests</subject><subject>Proportional Hazards Models</subject><subject>Renin-Angiotensin System - drug effects</subject><subject>Risk Factors</subject><subject>Secondary Prevention</subject><subject>Treatment Outcome</subject><issn>1099-5129</issn><issn>1532-2092</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKxDAUhoMojre1O8lOEKq5TJt2KeINBDe6Lml7qtVcak4i-BI-sxlmdOsqP5wvH8n5CTnm7JyzRl5ACn7WPeQwy1ptkT1eSlEI1ojtnFnTFCUXzYLsI74xxpRoyl2yEIxVy1qIPfL99Ap0stkRqR8pRh0nh1S7gQZwkyu0e5l8BIerbAaPEYJ3QPErJ0s74_t3CEi9o3My1jsdvugnTC47YkiWTuhNlua5T7H3FpDm4ZxFhQWXX59QGzqC1QbwkOyM2iAcbc4D8nxz_XR1Vzw83t5fXT4U_VLWsZCccRCdUlBzqZaDVlWnq1qPoPtK1zCMivUdqHpoSmAl41U9jGK1Gj3wTjB5QE7X3jn4jwQYWzthD8ZoBz5hq6RsyqWQPJMXa7IPHjHA2M5hsvmTLWftqoP2t4N23UG-cbJxp87C8Mf_Lj0DZ2vAp_lf2w8dF5j4</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Patel, Dimpi</creator><creator>Mohanty, Prasant</creator><creator>Di Biase, Luigi</creator><creator>Wang, Yan</creator><creator>Shaheen, Mazen H.</creator><creator>Sanchez, Javier E.</creator><creator>Horton, Rodney P.</creator><creator>Gallinghouse, G. Joseph</creator><creator>Zagrodzky, Jason D.</creator><creator>Bailey, Shane M.</creator><creator>Burkhardt, J. David</creator><creator>Lewis, William R.</creator><creator>Diaz, Alberto</creator><creator>Beheiry, Salwa</creator><creator>Hongo, Richard</creator><creator>Al-Ahmad, Amin</creator><creator>Wang, Paul</creator><creator>Schweikert, Robert</creator><creator>Natale, Andrea</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100301</creationdate><title>The impact of statins and renin-angiotensin-aldosterone system blockers on pulmonary vein antrum isolation outcomes in post-menopausal females</title><author>Patel, Dimpi ; Mohanty, Prasant ; Di Biase, Luigi ; Wang, Yan ; Shaheen, Mazen H. ; Sanchez, Javier E. ; Horton, Rodney P. ; Gallinghouse, G. Joseph ; Zagrodzky, Jason D. ; Bailey, Shane M. ; Burkhardt, J. 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Joseph</creatorcontrib><creatorcontrib>Zagrodzky, Jason D.</creatorcontrib><creatorcontrib>Bailey, Shane M.</creatorcontrib><creatorcontrib>Burkhardt, J. David</creatorcontrib><creatorcontrib>Lewis, William R.</creatorcontrib><creatorcontrib>Diaz, Alberto</creatorcontrib><creatorcontrib>Beheiry, Salwa</creatorcontrib><creatorcontrib>Hongo, Richard</creatorcontrib><creatorcontrib>Al-Ahmad, Amin</creatorcontrib><creatorcontrib>Wang, Paul</creatorcontrib><creatorcontrib>Schweikert, Robert</creatorcontrib><creatorcontrib>Natale, Andrea</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Europace (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Patel, Dimpi</au><au>Mohanty, Prasant</au><au>Di Biase, Luigi</au><au>Wang, Yan</au><au>Shaheen, Mazen H.</au><au>Sanchez, Javier E.</au><au>Horton, Rodney P.</au><au>Gallinghouse, G. Joseph</au><au>Zagrodzky, Jason D.</au><au>Bailey, Shane M.</au><au>Burkhardt, J. David</au><au>Lewis, William R.</au><au>Diaz, Alberto</au><au>Beheiry, Salwa</au><au>Hongo, Richard</au><au>Al-Ahmad, Amin</au><au>Wang, Paul</au><au>Schweikert, Robert</au><au>Natale, Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of statins and renin-angiotensin-aldosterone system blockers on pulmonary vein antrum isolation outcomes in post-menopausal females</atitle><jtitle>Europace (London, England)</jtitle><addtitle>Europace</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>12</volume><issue>3</issue><spage>322</spage><epage>330</epage><pages>322-330</pages><issn>1099-5129</issn><eissn>1532-2092</eissn><abstract>Aims To assess whether treatment with statins or renin-angiotensin-aldosterone system (RAAS) inhibitors as potential procedural 'augmenting agents' improved atrial fibrillation (AF) catheter ablation recurrence rates in post-menopausal females (PMFS). Methods and results Five hundred and eighteen consecutive female patients had undergone AF catheter ablation from January 2005 to May 2008. Post-menopausal females were selected and procedure outcomes were compared between cohorts of PMFS treated with statins or RAAS inhibitors to untreated PMFS. Out of 408 PMFS, 36 (8.8%) were treated with a combination of RAAS inhibitors and statins, thus were excluded leaving a total of 372 (91.2%) patients in the study. Out of 372 patients, 111 (29.8%) were on statins (Group 1), 59 (15.9%) on RAAS inhibitors (Group 2), and 202 (54.3%) without RAAS inhibitors or statins [(Group 3) control population]. Over a mean follow-up time of 24 ± 8.3 (median 25) months, 78 (70.6%) in Group 1, 38 (65.4%) in Group 2, and 139 (68.8%) in Group 3 had procedural success. Statin or RAAS inhibitor use did not predict lower recurrence rates [hazard ratio (HR): 1.26, P = 0.282 and HR: 1.14, P = 0.728, respectively]. When compared with controls, no difference in the cumulative incidence of recurrence was found with statin or RAAS inhibitors use (P = 0.385 and P = 0.761, respectively). Conclusion Treatment with statins or RAAS inhibitors did not improve catheter ablation success rates among PMFS. Thereby, from a clinical standpoint, PMFS should not be started on these treatments as a procedural 'augmenting agent' at this time.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>20064822</pmid><doi>10.1093/europace/eup387</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
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subjects Aged
Angiotensin II Type 1 Receptor Blockers - therapeutic use
Atrial Fibrillation - drug therapy
Atrial Fibrillation - epidemiology
Atrial Fibrillation - surgery
C-Reactive Protein - metabolism
Catheter Ablation - methods
Catheter Ablation - statistics & numerical data
Combined Modality Therapy
Female
Follow-Up Studies
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Kaplan-Meier Estimate
Middle Aged
Postmenopause
Postoperative Complications - epidemiology
Postoperative Complications - prevention & control
Predictive Value of Tests
Proportional Hazards Models
Renin-Angiotensin System - drug effects
Risk Factors
Secondary Prevention
Treatment Outcome
title The impact of statins and renin-angiotensin-aldosterone system blockers on pulmonary vein antrum isolation outcomes in post-menopausal females
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