c-MET pathway involvement in chronic rhinosinusitis: A genetic association analysis
The c-MET receptor and its ligand hepatocyte growth factor (HGF) has been shown to be overexpressed in tissue from chronic rhinosinusitis (CRS) patients with nasal polyps compared with that from controls. We assessed the genetic association of polymorphisms in the met proto-oncogene (MET) gene with...
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| Veröffentlicht in: | Otolaryngology-head and neck surgery 2010-05, Vol.142 (5), p.665-671 |
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| creator | Castano, Roberto Bossé, Yohan Endam, Leandra Mfuna Filali-Mouhim, Abdelali Desrosiers, Martin |
| description | The c-MET receptor and its ligand hepatocyte growth factor (HGF) has been shown to be overexpressed in tissue from chronic rhinosinusitis (CRS) patients with nasal polyps compared with that from controls. We assessed the genetic association of polymorphisms in the met proto-oncogene (MET) gene with CRS.
Case-control genetic association study.
Tertiary-care university hospital.
A total of 206 unrelated Canadian patients with CRS and 196 control subjects were enrolled. Subjects were genotyped for 33 polymorphisms in the MET gene.
The allelic association analysis showed eight single nucleotide polymorphisms in the MET gene (rs38850, rs38855, rs38857, rs2237717, rs2402118, rs193688, rs1621, rs42336) with a statistically significant association with CRS. The rs38850 T allele showed the strongest association and the highest risk for CRS (
P = 0.004; odds ratio 1.65, 95% confidence interval 1.18-2.32); the association did not reach statistical significance after adjustment for genomic control (
P = 0.06). The haplotype TGG constructed of markers rs38850, rs38855, and rs38857 represented a risk haplotype, resulting in a
P value of 0.003 that remained significant after correction for multiple testing (
P = 0.018).
These data suggest that polymorphisms in the MET gene may play a role in the susceptibility to develop CRS. Study findings apply to patients with severe CRS unresponsive to surgery. |
| doi_str_mv | 10.1016/j.otohns.2010.01.004 |
| format | Article |
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Case-control genetic association study.
Tertiary-care university hospital.
A total of 206 unrelated Canadian patients with CRS and 196 control subjects were enrolled. Subjects were genotyped for 33 polymorphisms in the MET gene.
The allelic association analysis showed eight single nucleotide polymorphisms in the MET gene (rs38850, rs38855, rs38857, rs2237717, rs2402118, rs193688, rs1621, rs42336) with a statistically significant association with CRS. The rs38850 T allele showed the strongest association and the highest risk for CRS (
P = 0.004; odds ratio 1.65, 95% confidence interval 1.18-2.32); the association did not reach statistical significance after adjustment for genomic control (
P = 0.06). The haplotype TGG constructed of markers rs38850, rs38855, and rs38857 represented a risk haplotype, resulting in a
P value of 0.003 that remained significant after correction for multiple testing (
P = 0.018).
These data suggest that polymorphisms in the MET gene may play a role in the susceptibility to develop CRS. Study findings apply to patients with severe CRS unresponsive to surgery.</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1016/j.otohns.2010.01.004</identifier><identifier>PMID: 20416453</identifier><language>eng</language><publisher>Los Angeles, CA: Mosby, Inc</publisher><subject>Chronic Disease ; Female ; Genome-Wide Association Study ; Hepatocyte Growth Factor - analysis ; Humans ; Male ; Middle Aged ; Nasal Polyps - complications ; Polymorphism, Single Nucleotide ; Proto-Oncogene Proteins c-met - analysis ; Rhinitis - complications ; Rhinitis - genetics ; Sinusitis - complications ; Sinusitis - genetics</subject><ispartof>Otolaryngology-head and neck surgery, 2010-05, Vol.142 (5), p.665-671</ispartof><rights>2010 American Academy of Otolaryngology–Head and Neck Surgery Foundation</rights><rights>2010 SAGE Publications</rights><rights>2010 American Association of Otolaryngology‐Head and Neck Surgery Foundation (AAO‐HNSF)</rights><rights>Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5228-aa895940a134338765cfe2464703621db2635ec45a66ce804a16971d56350c9f3</citedby><cites>FETCH-LOGICAL-c5228-aa895940a134338765cfe2464703621db2635ec45a66ce804a16971d56350c9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1016/j.otohns.2010.01.004$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1016/j.otohns.2010.01.004$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,1417,21819,27924,27925,43621,43622,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20416453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castano, Roberto</creatorcontrib><creatorcontrib>Bossé, Yohan</creatorcontrib><creatorcontrib>Endam, Leandra Mfuna</creatorcontrib><creatorcontrib>Filali-Mouhim, Abdelali</creatorcontrib><creatorcontrib>Desrosiers, Martin</creatorcontrib><title>c-MET pathway involvement in chronic rhinosinusitis: A genetic association analysis</title><title>Otolaryngology-head and neck surgery</title><addtitle>Otolaryngol Head Neck Surg</addtitle><description>The c-MET receptor and its ligand hepatocyte growth factor (HGF) has been shown to be overexpressed in tissue from chronic rhinosinusitis (CRS) patients with nasal polyps compared with that from controls. We assessed the genetic association of polymorphisms in the met proto-oncogene (MET) gene with CRS.
Case-control genetic association study.
Tertiary-care university hospital.
A total of 206 unrelated Canadian patients with CRS and 196 control subjects were enrolled. Subjects were genotyped for 33 polymorphisms in the MET gene.
The allelic association analysis showed eight single nucleotide polymorphisms in the MET gene (rs38850, rs38855, rs38857, rs2237717, rs2402118, rs193688, rs1621, rs42336) with a statistically significant association with CRS. The rs38850 T allele showed the strongest association and the highest risk for CRS (
P = 0.004; odds ratio 1.65, 95% confidence interval 1.18-2.32); the association did not reach statistical significance after adjustment for genomic control (
P = 0.06). The haplotype TGG constructed of markers rs38850, rs38855, and rs38857 represented a risk haplotype, resulting in a
P value of 0.003 that remained significant after correction for multiple testing (
P = 0.018).
These data suggest that polymorphisms in the MET gene may play a role in the susceptibility to develop CRS. Study findings apply to patients with severe CRS unresponsive to surgery.</description><subject>Chronic Disease</subject><subject>Female</subject><subject>Genome-Wide Association Study</subject><subject>Hepatocyte Growth Factor - analysis</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nasal Polyps - complications</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Proto-Oncogene Proteins c-met - analysis</subject><subject>Rhinitis - complications</subject><subject>Rhinitis - genetics</subject><subject>Sinusitis - complications</subject><subject>Sinusitis - genetics</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0EokvhHyCUG6dsxx9xYoSQStVSpEIPlLPlOrNdr7L24km22n-Pq5QegZOt8fu8Yz2MveWw5MD1yWaZxrSOtBRQRsCXAOoZW3Awba073j5nC-BG1Y0x3RF7RbQBAK3b9iU7EqC4Vo1csB--_nZ-U-3cuL53hyrEfRr2uMU4lnvl1znF4Ku8DjFRiBOFMdCH6rS6w4hjeXFEyQc3hhQrF91woECv2YuVGwjfPJ7H7OfF-c3ZZX11_eXr2elV7Rshutq5zjRGgeNSSdm1uvErFEqrFqQWvL8VWjboVeO09tiBclyblvdNGYM3K3nM3s-9u5x-TUij3QbyOAwuYprItlKahgslSlLNSZ8TUcaV3eWwdflgOdgHm3ZjZ5v2waYFbovNgr17XDDdbrF_gv7oK4GPc-A-DHj4r1J7ffn98wXvpOkKzmec3B3aTZpyMUj_-tOnmcFidh8wW_IBo8c-ZPSj7VP4e8Fv1JOqCw</recordid><startdate>201005</startdate><enddate>201005</enddate><creator>Castano, Roberto</creator><creator>Bossé, Yohan</creator><creator>Endam, Leandra Mfuna</creator><creator>Filali-Mouhim, Abdelali</creator><creator>Desrosiers, Martin</creator><general>Mosby, Inc</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201005</creationdate><title>c-MET pathway involvement in chronic rhinosinusitis: A genetic association analysis</title><author>Castano, Roberto ; Bossé, Yohan ; Endam, Leandra Mfuna ; Filali-Mouhim, Abdelali ; Desrosiers, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5228-aa895940a134338765cfe2464703621db2635ec45a66ce804a16971d56350c9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Chronic Disease</topic><topic>Female</topic><topic>Genome-Wide Association Study</topic><topic>Hepatocyte Growth Factor - analysis</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nasal Polyps - complications</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Proto-Oncogene Proteins c-met - analysis</topic><topic>Rhinitis - complications</topic><topic>Rhinitis - genetics</topic><topic>Sinusitis - complications</topic><topic>Sinusitis - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castano, Roberto</creatorcontrib><creatorcontrib>Bossé, Yohan</creatorcontrib><creatorcontrib>Endam, Leandra Mfuna</creatorcontrib><creatorcontrib>Filali-Mouhim, Abdelali</creatorcontrib><creatorcontrib>Desrosiers, Martin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castano, Roberto</au><au>Bossé, Yohan</au><au>Endam, Leandra Mfuna</au><au>Filali-Mouhim, Abdelali</au><au>Desrosiers, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>c-MET pathway involvement in chronic rhinosinusitis: A genetic association analysis</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>2010-05</date><risdate>2010</risdate><volume>142</volume><issue>5</issue><spage>665</spage><epage>671</epage><pages>665-671</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>The c-MET receptor and its ligand hepatocyte growth factor (HGF) has been shown to be overexpressed in tissue from chronic rhinosinusitis (CRS) patients with nasal polyps compared with that from controls. We assessed the genetic association of polymorphisms in the met proto-oncogene (MET) gene with CRS.
Case-control genetic association study.
Tertiary-care university hospital.
A total of 206 unrelated Canadian patients with CRS and 196 control subjects were enrolled. Subjects were genotyped for 33 polymorphisms in the MET gene.
The allelic association analysis showed eight single nucleotide polymorphisms in the MET gene (rs38850, rs38855, rs38857, rs2237717, rs2402118, rs193688, rs1621, rs42336) with a statistically significant association with CRS. The rs38850 T allele showed the strongest association and the highest risk for CRS (
P = 0.004; odds ratio 1.65, 95% confidence interval 1.18-2.32); the association did not reach statistical significance after adjustment for genomic control (
P = 0.06). The haplotype TGG constructed of markers rs38850, rs38855, and rs38857 represented a risk haplotype, resulting in a
P value of 0.003 that remained significant after correction for multiple testing (
P = 0.018).
These data suggest that polymorphisms in the MET gene may play a role in the susceptibility to develop CRS. Study findings apply to patients with severe CRS unresponsive to surgery.</abstract><cop>Los Angeles, CA</cop><pub>Mosby, Inc</pub><pmid>20416453</pmid><doi>10.1016/j.otohns.2010.01.004</doi><tpages>7</tpages></addata></record> |
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| subjects | Chronic Disease Female Genome-Wide Association Study Hepatocyte Growth Factor - analysis Humans Male Middle Aged Nasal Polyps - complications Polymorphism, Single Nucleotide Proto-Oncogene Proteins c-met - analysis Rhinitis - complications Rhinitis - genetics Sinusitis - complications Sinusitis - genetics |
| title | c-MET pathway involvement in chronic rhinosinusitis: A genetic association analysis |
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