Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis
A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro- N-(4-chlorophenyl)-5-nitrobenzamide 17 which exhibited low micromola...
Gespeichert in:
| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2010, Vol.20 (1), p.149-152 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 152 |
|---|---|
| container_issue | 1 |
| container_start_page | 149 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 20 |
| creator | Hwang, Jong Yeon Smithson, David Connelly, Michele Maier, Julie Zhu, Fangyi Guy, Kiplin R. |
| description | A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of
Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-
N-(4-chlorophenyl)-5-nitrobenzamide
17 which exhibited low micromolar inhibitory potency against
T. brucei and selectivity towards both malaria and mammalian cells. |
| doi_str_mv | 10.1016/j.bmcl.2009.11.022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733950484</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0960894X09015923</els_id><sourcerecordid>733950484</sourcerecordid><originalsourceid>FETCH-LOGICAL-c416t-c3ca86432625f9a37624b8a87f0a05e18b7157e987fc372f442a91cf92bc85703</originalsourceid><addsrcrecordid>eNp9kU9v1DAQxS0EotvCF-CAcgFOSf0vdixxqQoFpEq9gMTNmnht1qvEDra31fbT16tdwa2nkWZ-8zTzHkLvCO4IJuJy242zmTqKseoI6TClL9CKcMFbxnH_Eq2wErgdFP99hs5z3mJMOOb8NTojSgnGpFyh8YvPJt7btG-iazYwxTb4kuJowyPMfm1z8-DLpllisaF4mBpYlskbKD6GBv6AD7k0m90MoblyqQ5CU9J-gRBznD1kn9-gVw6mbN-e6gX6dfP15_X39vbu24_rq9vWcCJKa5iBQXBGBe2dAiYF5eMAg3QYcG_JMErSS6tqwzBJHecUFDFO0dEMvcTsAn066i4p_t3ZXPRcf7PTBMHGXdaSMdVjPvBKfnyWpIRSiaWoID2CJsWck3V6SX6GtNcE60MGeqsPGehDBpoQXTOoS-9P6rtxtuv_KyfTK_DhBEA2MLkEwfj8j6sShFOsKvf5yNnq2r23SWfjbTB27ZM1Ra-jf-6OJ22XpgE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21227076</pqid></control><display><type>article</type><title>Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Hwang, Jong Yeon ; Smithson, David ; Connelly, Michele ; Maier, Julie ; Zhu, Fangyi ; Guy, Kiplin R.</creator><creatorcontrib>Hwang, Jong Yeon ; Smithson, David ; Connelly, Michele ; Maier, Julie ; Zhu, Fangyi ; Guy, Kiplin R.</creatorcontrib><description>A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of
Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-
N-(4-chlorophenyl)-5-nitrobenzamide
17 which exhibited low micromolar inhibitory potency against
T. brucei and selectivity towards both malaria and mammalian cells.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2009.11.022</identifier><identifier>PMID: 19963377</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiparasitic agents ; Benzamides - chemical synthesis ; Benzamides - chemistry ; Benzamides - pharmacology ; Biological and medical sciences ; Drug Discovery ; HAT ; Humans ; Inhibitor ; Medical sciences ; Parasitic Sensitivity Tests ; Pharmacology. Drug treatments ; Trypanocidal Agents - chemical synthesis ; Trypanocidal Agents - chemistry ; Trypanocidal Agents - pharmacology ; Trypanosoma brucei brucei ; Trypanosoma brucei brucei - drug effects ; Trypanosomiasis ; Trypanosomiasis, African - drug therapy</subject><ispartof>Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.149-152</ispartof><rights>2009 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2009 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-c3ca86432625f9a37624b8a87f0a05e18b7157e987fc372f442a91cf92bc85703</citedby><cites>FETCH-LOGICAL-c416t-c3ca86432625f9a37624b8a87f0a05e18b7157e987fc372f442a91cf92bc85703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2009.11.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22314209$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19963377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, Jong Yeon</creatorcontrib><creatorcontrib>Smithson, David</creatorcontrib><creatorcontrib>Connelly, Michele</creatorcontrib><creatorcontrib>Maier, Julie</creatorcontrib><creatorcontrib>Zhu, Fangyi</creatorcontrib><creatorcontrib>Guy, Kiplin R.</creatorcontrib><title>Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of
Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-
N-(4-chlorophenyl)-5-nitrobenzamide
17 which exhibited low micromolar inhibitory potency against
T. brucei and selectivity towards both malaria and mammalian cells.</description><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiparasitic agents</subject><subject>Benzamides - chemical synthesis</subject><subject>Benzamides - chemistry</subject><subject>Benzamides - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Drug Discovery</subject><subject>HAT</subject><subject>Humans</subject><subject>Inhibitor</subject><subject>Medical sciences</subject><subject>Parasitic Sensitivity Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Trypanocidal Agents - chemical synthesis</subject><subject>Trypanocidal Agents - chemistry</subject><subject>Trypanocidal Agents - pharmacology</subject><subject>Trypanosoma brucei brucei</subject><subject>Trypanosoma brucei brucei - drug effects</subject><subject>Trypanosomiasis</subject><subject>Trypanosomiasis, African - drug therapy</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxS0EotvCF-CAcgFOSf0vdixxqQoFpEq9gMTNmnht1qvEDra31fbT16tdwa2nkWZ-8zTzHkLvCO4IJuJy242zmTqKseoI6TClL9CKcMFbxnH_Eq2wErgdFP99hs5z3mJMOOb8NTojSgnGpFyh8YvPJt7btG-iazYwxTb4kuJowyPMfm1z8-DLpllisaF4mBpYlskbKD6GBv6AD7k0m90MoblyqQ5CU9J-gRBznD1kn9-gVw6mbN-e6gX6dfP15_X39vbu24_rq9vWcCJKa5iBQXBGBe2dAiYF5eMAg3QYcG_JMErSS6tqwzBJHecUFDFO0dEMvcTsAn066i4p_t3ZXPRcf7PTBMHGXdaSMdVjPvBKfnyWpIRSiaWoID2CJsWck3V6SX6GtNcE60MGeqsPGehDBpoQXTOoS-9P6rtxtuv_KyfTK_DhBEA2MLkEwfj8j6sShFOsKvf5yNnq2r23SWfjbTB27ZM1Ra-jf-6OJ22XpgE</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Hwang, Jong Yeon</creator><creator>Smithson, David</creator><creator>Connelly, Michele</creator><creator>Maier, Julie</creator><creator>Zhu, Fangyi</creator><creator>Guy, Kiplin R.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis</title><author>Hwang, Jong Yeon ; Smithson, David ; Connelly, Michele ; Maier, Julie ; Zhu, Fangyi ; Guy, Kiplin R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-c3ca86432625f9a37624b8a87f0a05e18b7157e987fc372f442a91cf92bc85703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiparasitic agents</topic><topic>Benzamides - chemical synthesis</topic><topic>Benzamides - chemistry</topic><topic>Benzamides - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Drug Discovery</topic><topic>HAT</topic><topic>Humans</topic><topic>Inhibitor</topic><topic>Medical sciences</topic><topic>Parasitic Sensitivity Tests</topic><topic>Pharmacology. Drug treatments</topic><topic>Trypanocidal Agents - chemical synthesis</topic><topic>Trypanocidal Agents - chemistry</topic><topic>Trypanocidal Agents - pharmacology</topic><topic>Trypanosoma brucei brucei</topic><topic>Trypanosoma brucei brucei - drug effects</topic><topic>Trypanosomiasis</topic><topic>Trypanosomiasis, African - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hwang, Jong Yeon</creatorcontrib><creatorcontrib>Smithson, David</creatorcontrib><creatorcontrib>Connelly, Michele</creatorcontrib><creatorcontrib>Maier, Julie</creatorcontrib><creatorcontrib>Zhu, Fangyi</creatorcontrib><creatorcontrib>Guy, Kiplin R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, Jong Yeon</au><au>Smithson, David</au><au>Connelly, Michele</au><au>Maier, Julie</au><au>Zhu, Fangyi</au><au>Guy, Kiplin R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2010</date><risdate>2010</risdate><volume>20</volume><issue>1</issue><spage>149</spage><epage>152</epage><pages>149-152</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of
Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-
N-(4-chlorophenyl)-5-nitrobenzamide
17 which exhibited low micromolar inhibitory potency against
T. brucei and selectivity towards both malaria and mammalian cells.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>19963377</pmid><doi>10.1016/j.bmcl.2009.11.022</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.149-152 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733950484 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Benzamides - chemical synthesis Benzamides - chemistry Benzamides - pharmacology Biological and medical sciences Drug Discovery HAT Humans Inhibitor Medical sciences Parasitic Sensitivity Tests Pharmacology. Drug treatments Trypanocidal Agents - chemical synthesis Trypanocidal Agents - chemistry Trypanocidal Agents - pharmacology Trypanosoma brucei brucei Trypanosoma brucei brucei - drug effects Trypanosomiasis Trypanosomiasis, African - drug therapy |
| title | Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T15%3A29%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Discovery%20of%20halo-nitrobenzamides%20with%20potential%20application%20against%20human%20African%20trypanosomiasis&rft.jtitle=Bioorganic%20&%20medicinal%20chemistry%20letters&rft.au=Hwang,%20Jong%20Yeon&rft.date=2010&rft.volume=20&rft.issue=1&rft.spage=149&rft.epage=152&rft.pages=149-152&rft.issn=0960-894X&rft.eissn=1464-3405&rft_id=info:doi/10.1016/j.bmcl.2009.11.022&rft_dat=%3Cproquest_cross%3E733950484%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=21227076&rft_id=info:pmid/19963377&rft_els_id=S0960894X09015923&rfr_iscdi=true |