Perioperative Antibiotic Prophylaxis for Nonlaboring Cesarean Delivery
To estimate the efficacy of antibiotic prophylaxis at the time of nonlaboring cesarean delivery in reducing postpartum infection-related complications. We performed a secondary analysis of an observational study of cesarean deliveries performed at 13 centers from 1999-2000. Patients were included if...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 2009-10, Vol.114 (4), p.752-756 |
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| creator | Dinsmoor, Mara J. Gilbert, Sharon Landon, Mark B. Rouse, Dwight J. Spong, Catherine Y. Varner, Michael W. Caritis, Steve N. Wapner, Ronald J. Sorokin, Yoram Miodovnik, Menachem O’Sullivan, Mary J. Sibai, Baha M. Langer, Oded |
| description | To estimate the efficacy of antibiotic prophylaxis at the time of nonlaboring cesarean delivery in reducing postpartum infection-related complications.
We performed a secondary analysis of an observational study of cesarean deliveries performed at 13 centers from 1999-2000. Patients were included if they had cesarean delivery before labor, did not have intrapartum infection, and were not given antibiotics at delivery for reasons other than prophylaxis. The occurrence of postpartum endometritis, wound infection, and other, less common infection-related complications was compared between those who did and did not receive antibiotic prophylaxis. Results were adjusted for smoking, payer status, gestational age and body mass index at delivery, race, diabetes, antepartum infections, presence of anemia, operative time, type of cesarean delivery (primary or repeat), and center.
Of the 9,432 women who met study criteria, the 6,006 (64%) who received antibiotic prophylaxis were younger, heavier at delivery, and were more likely to be African American, receive public insurance, and have diabetes. Patients who received antibiotic prophylaxis were less likely to develop postpartum endometritis (121 [2.0%] compared with 88 [2.6%], adjusted odds ratio [OR] 0.40, 95% confidence interval [CI] 0.28-0.59) or wound infection (31 [0.52%] compared with 33 [0.96%], adjusted OR 0.49, 95% CI 0.28-0.86).
Antibiotic prophylaxis at the time of nonlaboring cesarean delivery significantly reduces the risks of postpartum endometritis and wound infection.
III. |
| doi_str_mv | 10.1097/AOG.0b013e3181b8f28f |
| format | Article |
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We performed a secondary analysis of an observational study of cesarean deliveries performed at 13 centers from 1999-2000. Patients were included if they had cesarean delivery before labor, did not have intrapartum infection, and were not given antibiotics at delivery for reasons other than prophylaxis. The occurrence of postpartum endometritis, wound infection, and other, less common infection-related complications was compared between those who did and did not receive antibiotic prophylaxis. Results were adjusted for smoking, payer status, gestational age and body mass index at delivery, race, diabetes, antepartum infections, presence of anemia, operative time, type of cesarean delivery (primary or repeat), and center.
Of the 9,432 women who met study criteria, the 6,006 (64%) who received antibiotic prophylaxis were younger, heavier at delivery, and were more likely to be African American, receive public insurance, and have diabetes. Patients who received antibiotic prophylaxis were less likely to develop postpartum endometritis (121 [2.0%] compared with 88 [2.6%], adjusted odds ratio [OR] 0.40, 95% confidence interval [CI] 0.28-0.59) or wound infection (31 [0.52%] compared with 33 [0.96%], adjusted OR 0.49, 95% CI 0.28-0.86).
Antibiotic prophylaxis at the time of nonlaboring cesarean delivery significantly reduces the risks of postpartum endometritis and wound infection.
III.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1097/AOG.0b013e3181b8f28f</identifier><identifier>PMID: 19888031</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>Hagerstown, MD: by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Antibacterial agents ; Antibiotic Prophylaxis ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Cesarean Section ; Endometriosis - prevention & control ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Odds Ratio ; Perioperative Care ; Pharmacology. Drug treatments ; Pregnancy ; Puerperal Infection - prevention & control ; Surgical Wound Infection - prevention & control ; Young Adult</subject><ispartof>Obstetrics and gynecology (New York. 1953), 2009-10, Vol.114 (4), p.752-756</ispartof><rights>by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4278-afa57e48f06bfe21dc84086d19a49c9483dbe74375f9737167c95e1492b5978c3</citedby><cites>FETCH-LOGICAL-c4278-afa57e48f06bfe21dc84086d19a49c9483dbe74375f9737167c95e1492b5978c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21964298$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19888031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dinsmoor, Mara J.</creatorcontrib><creatorcontrib>Gilbert, Sharon</creatorcontrib><creatorcontrib>Landon, Mark B.</creatorcontrib><creatorcontrib>Rouse, Dwight J.</creatorcontrib><creatorcontrib>Spong, Catherine Y.</creatorcontrib><creatorcontrib>Varner, Michael W.</creatorcontrib><creatorcontrib>Caritis, Steve N.</creatorcontrib><creatorcontrib>Wapner, Ronald J.</creatorcontrib><creatorcontrib>Sorokin, Yoram</creatorcontrib><creatorcontrib>Miodovnik, Menachem</creatorcontrib><creatorcontrib>O’Sullivan, Mary J.</creatorcontrib><creatorcontrib>Sibai, Baha M.</creatorcontrib><creatorcontrib>Langer, Oded</creatorcontrib><creatorcontrib>Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network</creatorcontrib><title>Perioperative Antibiotic Prophylaxis for Nonlaboring Cesarean Delivery</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>To estimate the efficacy of antibiotic prophylaxis at the time of nonlaboring cesarean delivery in reducing postpartum infection-related complications.
We performed a secondary analysis of an observational study of cesarean deliveries performed at 13 centers from 1999-2000. Patients were included if they had cesarean delivery before labor, did not have intrapartum infection, and were not given antibiotics at delivery for reasons other than prophylaxis. The occurrence of postpartum endometritis, wound infection, and other, less common infection-related complications was compared between those who did and did not receive antibiotic prophylaxis. Results were adjusted for smoking, payer status, gestational age and body mass index at delivery, race, diabetes, antepartum infections, presence of anemia, operative time, type of cesarean delivery (primary or repeat), and center.
Of the 9,432 women who met study criteria, the 6,006 (64%) who received antibiotic prophylaxis were younger, heavier at delivery, and were more likely to be African American, receive public insurance, and have diabetes. Patients who received antibiotic prophylaxis were less likely to develop postpartum endometritis (121 [2.0%] compared with 88 [2.6%], adjusted odds ratio [OR] 0.40, 95% confidence interval [CI] 0.28-0.59) or wound infection (31 [0.52%] compared with 33 [0.96%], adjusted OR 0.49, 95% CI 0.28-0.86).
Antibiotic prophylaxis at the time of nonlaboring cesarean delivery significantly reduces the risks of postpartum endometritis and wound infection.
III.</description><subject>Adult</subject><subject>Antibacterial agents</subject><subject>Antibiotic Prophylaxis</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Cesarean Section</subject><subject>Endometriosis - prevention & control</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Odds Ratio</subject><subject>Perioperative Care</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Puerperal Infection - prevention & control</subject><subject>Surgical Wound Infection - prevention & control</subject><subject>Young Adult</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcFuEzEQhi0EoqHwBgjtBXHaMmN71_YxSmlBqmgPIHGzvM6YGJx1sDeUvD0bNaISlxmN9P0z0jeMvUa4QDDq_fL2-gIGQEECNQ46cB2esAVqJVouxLenbAHATau0lGfsRa0_AAB7I56zMzRaaxC4YFd3VGLeUXFT_E3NcpziEPMUfXNX8m5zSO5PrE3Ipfmcx-SGXOL4vVlRdYXc2FxSmmPl8JI9Cy5VenXq5-zr1Ycvq4_tze31p9XypvWSK9264DpFUgfoh0Ac115L0P0ajZPGG6nFeiAlheqCUUJhr7zpCKXhQ2eU9uKcvXvYuyv5157qZLexekrJjZT31SohTAfY8ZmUD6QvudZCwe5K3LpysAj2KNDOAu3_AufYm9OB_bCl9WPoZGwG3p4AV71LobjRx_qP42h6yY1-vH-f00Sl_kz7eyp2Qy5NGzu_AnreQcsBDB6n9li0-As_YImY</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Dinsmoor, Mara J.</creator><creator>Gilbert, Sharon</creator><creator>Landon, Mark B.</creator><creator>Rouse, Dwight J.</creator><creator>Spong, Catherine Y.</creator><creator>Varner, Michael W.</creator><creator>Caritis, Steve N.</creator><creator>Wapner, Ronald J.</creator><creator>Sorokin, Yoram</creator><creator>Miodovnik, Menachem</creator><creator>O’Sullivan, Mary J.</creator><creator>Sibai, Baha M.</creator><creator>Langer, Oded</creator><general>by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091001</creationdate><title>Perioperative Antibiotic Prophylaxis for Nonlaboring Cesarean Delivery</title><author>Dinsmoor, Mara J. ; Gilbert, Sharon ; Landon, Mark B. ; Rouse, Dwight J. ; Spong, Catherine Y. ; Varner, Michael W. ; Caritis, Steve N. ; Wapner, Ronald J. ; Sorokin, Yoram ; Miodovnik, Menachem ; O’Sullivan, Mary J. ; Sibai, Baha M. ; Langer, Oded</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4278-afa57e48f06bfe21dc84086d19a49c9483dbe74375f9737167c95e1492b5978c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Antibacterial agents</topic><topic>Antibiotic Prophylaxis</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Cesarean Section</topic><topic>Endometriosis - prevention & control</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Odds Ratio</topic><topic>Perioperative Care</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Puerperal Infection - prevention & control</topic><topic>Surgical Wound Infection - prevention & control</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dinsmoor, Mara J.</creatorcontrib><creatorcontrib>Gilbert, Sharon</creatorcontrib><creatorcontrib>Landon, Mark B.</creatorcontrib><creatorcontrib>Rouse, Dwight J.</creatorcontrib><creatorcontrib>Spong, Catherine Y.</creatorcontrib><creatorcontrib>Varner, Michael W.</creatorcontrib><creatorcontrib>Caritis, Steve N.</creatorcontrib><creatorcontrib>Wapner, Ronald J.</creatorcontrib><creatorcontrib>Sorokin, Yoram</creatorcontrib><creatorcontrib>Miodovnik, Menachem</creatorcontrib><creatorcontrib>O’Sullivan, Mary J.</creatorcontrib><creatorcontrib>Sibai, Baha M.</creatorcontrib><creatorcontrib>Langer, Oded</creatorcontrib><creatorcontrib>Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dinsmoor, Mara J.</au><au>Gilbert, Sharon</au><au>Landon, Mark B.</au><au>Rouse, Dwight J.</au><au>Spong, Catherine Y.</au><au>Varner, Michael W.</au><au>Caritis, Steve N.</au><au>Wapner, Ronald J.</au><au>Sorokin, Yoram</au><au>Miodovnik, Menachem</au><au>O’Sullivan, Mary J.</au><au>Sibai, Baha M.</au><au>Langer, Oded</au><aucorp>Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perioperative Antibiotic Prophylaxis for Nonlaboring Cesarean Delivery</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>114</volume><issue>4</issue><spage>752</spage><epage>756</epage><pages>752-756</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>To estimate the efficacy of antibiotic prophylaxis at the time of nonlaboring cesarean delivery in reducing postpartum infection-related complications.
We performed a secondary analysis of an observational study of cesarean deliveries performed at 13 centers from 1999-2000. Patients were included if they had cesarean delivery before labor, did not have intrapartum infection, and were not given antibiotics at delivery for reasons other than prophylaxis. The occurrence of postpartum endometritis, wound infection, and other, less common infection-related complications was compared between those who did and did not receive antibiotic prophylaxis. Results were adjusted for smoking, payer status, gestational age and body mass index at delivery, race, diabetes, antepartum infections, presence of anemia, operative time, type of cesarean delivery (primary or repeat), and center.
Of the 9,432 women who met study criteria, the 6,006 (64%) who received antibiotic prophylaxis were younger, heavier at delivery, and were more likely to be African American, receive public insurance, and have diabetes. Patients who received antibiotic prophylaxis were less likely to develop postpartum endometritis (121 [2.0%] compared with 88 [2.6%], adjusted odds ratio [OR] 0.40, 95% confidence interval [CI] 0.28-0.59) or wound infection (31 [0.52%] compared with 33 [0.96%], adjusted OR 0.49, 95% CI 0.28-0.86).
Antibiotic prophylaxis at the time of nonlaboring cesarean delivery significantly reduces the risks of postpartum endometritis and wound infection.
III.</abstract><cop>Hagerstown, MD</cop><pub>by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>19888031</pmid><doi>10.1097/AOG.0b013e3181b8f28f</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Obstetrics and gynecology (New York. 1953), 2009-10, Vol.114 (4), p.752-756 |
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| subjects | Adult Antibacterial agents Antibiotic Prophylaxis Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cesarean Section Endometriosis - prevention & control Female Gynecology. Andrology. Obstetrics Humans Medical sciences Odds Ratio Perioperative Care Pharmacology. Drug treatments Pregnancy Puerperal Infection - prevention & control Surgical Wound Infection - prevention & control Young Adult |
| title | Perioperative Antibiotic Prophylaxis for Nonlaboring Cesarean Delivery |
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