Effects of intravenous and infravesical administration of suramin, terazosin and BMY 7378 on bladder instability in conscious rats with bladder outlet obstruction

OBJECTIVE To evaluate the effect of the nonselective purinergic antagonist suramin and the α1‐adrenergic antagonists, terazosin and BMY 7378, given intravenously or infused directly into the bladder during cystometry in conscious rats with bladder outlet obstruction induced by urethral ligation. MAT...

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Veröffentlicht in:	BJU international 2003-07, Vol.92 (1), p.131-136
Hauptverfasser:	Velasco, C., Guarneri, L., Leonardi, A., Testa, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravesical Adrenergic alpha-Antagonists - administration & dosage Animals Biological and medical sciences cystometry Female Infusions, Intravenous Ligation Medical sciences micturition reflex Nephrology. Urinary tract diseases Piperazines - administration & dosage Prazosin - administration & dosage Prazosin - analogs & derivatives Purinergic Antagonists Rats Rats, Sprague-Dawley Suramin - administration & dosage Urethral Obstruction - drug therapy Urinary Bladder Neck Obstruction - complications Urinary Bladder Neck Obstruction - physiopathology Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland Urination - drug effects Urination Disorders - drug therapy Urination Disorders - etiology Urination Disorders - physiopathology Urodynamics α1‐antagonists
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