Alterations in Signal Transduction Molecules in T Lymphocytes from Tumor-Bearing Mice

Impaired immune responses occur frequently in cancer patients or in tumor-bearing mice, but the mechanisms of the tumor-induced immune defects remain poorly understood. In an in vivo murine colon carcinoma model (MCA-38), animals bearing a tumor longer than 26 days develop CD8$^+$ T cells with impai...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1992-12, Vol.258 (5089), p.1795-1798
Hauptverfasser:	Mizoguchi, Hiromoto, O'Shea, John J., Longo, Dan L., Loeffler, Cynthia M., McVicar, Daniel W., Ochoa, Augusto C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antigen receptors, T cell Biological and medical sciences Calcium - metabolism Cancer Causes of CD3 Complex - metabolism CD8 Antigens - analysis Cell lines Colonic Neoplasms - immunology Cytotoxicity, Immunologic Fluorescence Granzymes Host-tumor relations. Immunology. Biological markers Immunodeficiency Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Macromolecular Substances Medical sciences Mice Molecules Phosphorylation Physiological aspects Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-fyn Receptors Receptors, Antigen, T-Cell - isolation & purification Receptors, Antigen, T-Cell - metabolism Receptors, IgG - metabolism Serine Endopeptidases - biosynthesis Serine Endopeptidases - genetics Signal Transduction T cell antigen receptors T cells T lymphocytes T-Lymphocyte Subsets - immunology T-Lymphocytes - immunology T-Lymphocytes - physiology Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics Tumors
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