Dose conversion between tapentadol immediate and extended release for low back pain

Tapentadol, a novel, centrally acting analgesic with 2 mechanisms of action (mu-opioid receptor agonism and norepinephrine reuptake inhibition), has been developed in an immediate-release (IR) and an extended-release (ER) formulation. Determination of the safety and equianalgesic ratios for conversi...

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Veröffentlicht in:	Pain physician 2010-01, Vol.13 (1), p.61-70
Hauptverfasser:	Etropolski, Mila S, Okamoto, Akiko, Shapiro, Douglas Y, Rauschkolb, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Uptake Inhibitors - administration & dosage Adult Aged Aged, 80 and over Analgesics Analgesics, Opioid - administration & dosage Back pain Chemistry, Pharmaceutical - statistics & numerical data Cross-Over Studies Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Female Humans Low Back Pain - drug therapy Male Middle Aged Outcome Assessment (Health Care) Phenols - administration & dosage Treatment Outcome Young Adult
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