Electrophysiological assessment of corticorespiratory pathway function in amyotrophic lateral sclerosis
Respiratory muscle paralysis is inevitable in the clinical course of amyotrophic lateral sclerosis (ALS). Our objective was to electrophysiologically assess the function of the phrenic nerve and diaphragm motor cortex in ALS. Phrenic nerve M waves, diaphragm motor evoked potentials (MEPs) induced by...
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| Veröffentlicht in: | Amyotrophic lateral sclerosis 2010, Vol.11 (1-2), p.57-6 |
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| container_title | Amyotrophic lateral sclerosis |
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| creator | Shimizu, Toshio Komori, Tetsuo Kugio, Yumiko Fujimaki, Yumi Oyanagi, Kiyomitsu Hayashi, Hideaki |
| description | Respiratory muscle paralysis is inevitable in the clinical course of amyotrophic lateral sclerosis (ALS). Our objective was to electrophysiologically assess the function of the phrenic nerve and diaphragm motor cortex in ALS. Phrenic nerve M waves, diaphragm motor evoked potentials (MEPs) induced by transcranial magnetic stimulation, and their clinical correlations were analyzed in 29 ALS patients. The M wave amplitude was significantly lower in patients than in healthy control subjects (p |
| doi_str_mv | 10.1080/17482960903207385 |
| format | Article |
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Our objective was to electrophysiologically assess the function of the phrenic nerve and diaphragm motor cortex in ALS. Phrenic nerve M waves, diaphragm motor evoked potentials (MEPs) induced by transcranial magnetic stimulation, and their clinical correlations were analyzed in 29 ALS patients. The M wave amplitude was significantly lower in patients than in healthy control subjects (p<0.001). The MEP amplitudes both in the expiratory and inspiratory phases were significantly decreased in patients (p<0.01). In particular, 15 patients showed no MEPs in the expiratory phase, six of whom also showed no MEPs in the inspiratory phase. Five of them had no respiratory complaints. There was a weak, non-significant correlation between the inspiratory MEP amplitude and forced vital capacity (p=0.052). We conclude that the loss of MEP might reflect the subclinical involvement of the voluntary respiratory drive from the diaphragm motor cortex, potentially leading to further respiratory deterioration.</description><identifier>ISSN: 1748-2968</identifier><identifier>EISSN: 1471-180X</identifier><identifier>DOI: 10.1080/17482960903207385</identifier><identifier>PMID: 19707909</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Amyotrophic Lateral Sclerosis - complications ; Amyotrophic Lateral Sclerosis - physiopathology ; Diaphragm - innervation ; Diaphragm - physiopathology ; Efferent Pathways - physiopathology ; Electromyography ; Exhalation - physiology ; Female ; Humans ; Inhalation - physiology ; Male ; Middle Aged ; Motor Cortex - physiopathology ; Neural Conduction ; Phrenic Nerve - physiology ; Respiratory Function Tests ; Respiratory Insufficiency - diagnosis ; Respiratory Insufficiency - etiology ; Respiratory Insufficiency - physiopathology ; Volition - physiology</subject><ispartof>Amyotrophic lateral sclerosis, 2010, Vol.11 (1-2), p.57-6</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2119-ce19430c58e82ab9088b345a3548d075542d2cef19303836c18c360671d4c0e12</citedby></display><links><openurl>$$Topenurl_article</openurl><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19707909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimizu, Toshio</creatorcontrib><creatorcontrib>Komori, Tetsuo</creatorcontrib><creatorcontrib>Kugio, Yumiko</creatorcontrib><creatorcontrib>Fujimaki, Yumi</creatorcontrib><creatorcontrib>Oyanagi, Kiyomitsu</creatorcontrib><creatorcontrib>Hayashi, Hideaki</creatorcontrib><title>Electrophysiological assessment of corticorespiratory pathway function in amyotrophic lateral sclerosis</title><title>Amyotrophic lateral sclerosis</title><addtitle>Amyotroph Lateral Scler</addtitle><description>Respiratory muscle paralysis is inevitable in the clinical course of amyotrophic lateral sclerosis (ALS). Our objective was to electrophysiologically assess the function of the phrenic nerve and diaphragm motor cortex in ALS. Phrenic nerve M waves, diaphragm motor evoked potentials (MEPs) induced by transcranial magnetic stimulation, and their clinical correlations were analyzed in 29 ALS patients. The M wave amplitude was significantly lower in patients than in healthy control subjects (p<0.001). The MEP amplitudes both in the expiratory and inspiratory phases were significantly decreased in patients (p<0.01). In particular, 15 patients showed no MEPs in the expiratory phase, six of whom also showed no MEPs in the inspiratory phase. Five of them had no respiratory complaints. There was a weak, non-significant correlation between the inspiratory MEP amplitude and forced vital capacity (p=0.052). We conclude that the loss of MEP might reflect the subclinical involvement of the voluntary respiratory drive from the diaphragm motor cortex, potentially leading to further respiratory deterioration.</description><subject>Adult</subject><subject>Aged</subject><subject>Amyotrophic Lateral Sclerosis - complications</subject><subject>Amyotrophic Lateral Sclerosis - physiopathology</subject><subject>Diaphragm - innervation</subject><subject>Diaphragm - physiopathology</subject><subject>Efferent Pathways - physiopathology</subject><subject>Electromyography</subject><subject>Exhalation - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Inhalation - physiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor Cortex - physiopathology</subject><subject>Neural Conduction</subject><subject>Phrenic Nerve - physiology</subject><subject>Respiratory Function Tests</subject><subject>Respiratory Insufficiency - diagnosis</subject><subject>Respiratory Insufficiency - etiology</subject><subject>Respiratory Insufficiency - physiopathology</subject><subject>Volition - physiology</subject><issn>1748-2968</issn><issn>1471-180X</issn><fulltext>false</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkEtLxDAUhYMojo7-ADfSnavqzaNNspRhfMCAGwV3JZOmM5G0qUkG6b83OgMu3Nx74Z7zcTgIXWG4xSDgDnMmiKxBAiXAqaiO0BlmHJdYwPtxvvO_zAIxQ-cxfgBURBJyimZYcuAS5BnaLJ3RKfhxO0Xrnd9YrVyhYjQx9mZIhe8K7UOyeZg42qCSD1MxqrT9UlPR7QadrB8KOxSqn_wvyerCqWRCBkXtTPDRxgt00ikXzeVhz9Hbw_J18VSuXh6fF_erUhOMZakNloyCroQRRK0lCLGmrFK0YqIFXlWMtESbDksKVNBaY6FpDTXHLdNgMJmjmz13DP5zZ2Jqehu1cU4Nxu9iwymVjDDGsxLvlToHjMF0zRhsr8LUYGh-6m3-1Zs91wf6bt2b9s9x6JN8A6_Adv8</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Shimizu, Toshio</creator><creator>Komori, Tetsuo</creator><creator>Kugio, Yumiko</creator><creator>Fujimaki, Yumi</creator><creator>Oyanagi, Kiyomitsu</creator><creator>Hayashi, Hideaki</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Electrophysiological assessment of corticorespiratory pathway function in amyotrophic lateral sclerosis</title><author>Shimizu, Toshio ; Komori, Tetsuo ; Kugio, Yumiko ; Fujimaki, Yumi ; Oyanagi, Kiyomitsu ; Hayashi, Hideaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2119-ce19430c58e82ab9088b345a3548d075542d2cef19303836c18c360671d4c0e12</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amyotrophic Lateral Sclerosis - complications</topic><topic>Amyotrophic Lateral Sclerosis - physiopathology</topic><topic>Diaphragm - innervation</topic><topic>Diaphragm - physiopathology</topic><topic>Efferent Pathways - physiopathology</topic><topic>Electromyography</topic><topic>Exhalation - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Inhalation - physiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor Cortex - physiopathology</topic><topic>Neural Conduction</topic><topic>Phrenic Nerve - physiology</topic><topic>Respiratory Function Tests</topic><topic>Respiratory Insufficiency - diagnosis</topic><topic>Respiratory Insufficiency - etiology</topic><topic>Respiratory Insufficiency - physiopathology</topic><topic>Volition - physiology</topic><creatorcontrib>Shimizu, Toshio</creatorcontrib><creatorcontrib>Komori, Tetsuo</creatorcontrib><creatorcontrib>Kugio, Yumiko</creatorcontrib><creatorcontrib>Fujimaki, Yumi</creatorcontrib><creatorcontrib>Oyanagi, Kiyomitsu</creatorcontrib><creatorcontrib>Hayashi, Hideaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Amyotrophic lateral sclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>no_fulltext</fulltext></delivery><addata><au>Shimizu, Toshio</au><au>Komori, Tetsuo</au><au>Kugio, Yumiko</au><au>Fujimaki, Yumi</au><au>Oyanagi, Kiyomitsu</au><au>Hayashi, Hideaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electrophysiological assessment of corticorespiratory pathway function in amyotrophic lateral sclerosis</atitle><jtitle>Amyotrophic lateral sclerosis</jtitle><addtitle>Amyotroph Lateral Scler</addtitle><date>2010</date><risdate>2010</risdate><volume>11</volume><issue>1-2</issue><spage>57</spage><epage>6</epage><pages>57-6</pages><issn>1748-2968</issn><eissn>1471-180X</eissn><abstract>Respiratory muscle paralysis is inevitable in the clinical course of amyotrophic lateral sclerosis (ALS). Our objective was to electrophysiologically assess the function of the phrenic nerve and diaphragm motor cortex in ALS. Phrenic nerve M waves, diaphragm motor evoked potentials (MEPs) induced by transcranial magnetic stimulation, and their clinical correlations were analyzed in 29 ALS patients. The M wave amplitude was significantly lower in patients than in healthy control subjects (p<0.001). The MEP amplitudes both in the expiratory and inspiratory phases were significantly decreased in patients (p<0.01). In particular, 15 patients showed no MEPs in the expiratory phase, six of whom also showed no MEPs in the inspiratory phase. Five of them had no respiratory complaints. There was a weak, non-significant correlation between the inspiratory MEP amplitude and forced vital capacity (p=0.052). We conclude that the loss of MEP might reflect the subclinical involvement of the voluntary respiratory drive from the diaphragm motor cortex, potentially leading to further respiratory deterioration.</abstract><cop>England</cop><pmid>19707909</pmid><doi>10.1080/17482960903207385</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Amyotrophic Lateral Sclerosis - complications Amyotrophic Lateral Sclerosis - physiopathology Diaphragm - innervation Diaphragm - physiopathology Efferent Pathways - physiopathology Electromyography Exhalation - physiology Female Humans Inhalation - physiology Male Middle Aged Motor Cortex - physiopathology Neural Conduction Phrenic Nerve - physiology Respiratory Function Tests Respiratory Insufficiency - diagnosis Respiratory Insufficiency - etiology Respiratory Insufficiency - physiopathology Volition - physiology |
| title | Electrophysiological assessment of corticorespiratory pathway function in amyotrophic lateral sclerosis |
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