Electrophysiological assessment of corticorespiratory pathway function in amyotrophic lateral sclerosis

Respiratory muscle paralysis is inevitable in the clinical course of amyotrophic lateral sclerosis (ALS). Our objective was to electrophysiologically assess the function of the phrenic nerve and diaphragm motor cortex in ALS. Phrenic nerve M waves, diaphragm motor evoked potentials (MEPs) induced by...

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Veröffentlicht in:	Amyotrophic lateral sclerosis 2010, Vol.11 (1-2), p.57-6
Hauptverfasser:	Shimizu, Toshio, Komori, Tetsuo, Kugio, Yumiko, Fujimaki, Yumi, Oyanagi, Kiyomitsu, Hayashi, Hideaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amyotrophic Lateral Sclerosis - complications Amyotrophic Lateral Sclerosis - physiopathology Diaphragm - innervation Diaphragm - physiopathology Efferent Pathways - physiopathology Electromyography Exhalation - physiology Female Humans Inhalation - physiology Male Middle Aged Motor Cortex - physiopathology Neural Conduction Phrenic Nerve - physiology Respiratory Function Tests Respiratory Insufficiency - diagnosis Respiratory Insufficiency - etiology Respiratory Insufficiency - physiopathology Volition - physiology
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Zusammenfassung:	Respiratory muscle paralysis is inevitable in the clinical course of amyotrophic lateral sclerosis (ALS). Our objective was to electrophysiologically assess the function of the phrenic nerve and diaphragm motor cortex in ALS. Phrenic nerve M waves, diaphragm motor evoked potentials (MEPs) induced by transcranial magnetic stimulation, and their clinical correlations were analyzed in 29 ALS patients. The M wave amplitude was significantly lower in patients than in healthy control subjects (p
ISSN:	1748-2968 1471-180X
DOI:	10.1080/17482960903207385