Monocyte Chemoattractant Protein-1 Contributes to Gut Homeostasis and Intestinal Inflammation by Composition of IL-10-Producing Regulatory Macrophage Subset

Lamina propria macrophages (LPMs) spontaneously produce large amounts of anti-inflammatory IL-10 and play a central role in regulation of immune responses against commensal bacteria. MCP-1 is a chemokine that plays an important role in recruitment of monocytes and macrophages to inflamed tissues. We...

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Veröffentlicht in:	The Journal of immunology (1950) 2010-03, Vol.184 (5), p.2671-2676
Hauptverfasser:	Takada, Yasuhiro, Hisamatsu, Tadakazu, Kamada, Nobuhiko, Kitazume, Mina T, Honda, Haruki, Oshima, Yosuke, Saito, Riko, Takayama, Tetsuro, Kobayashi, Taku, Chinen, Hiroshi, Mikami, Yohei, Kanai, Takanori, Okamoto, Susumu, Hibi, Toshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial - immunology CD11b Antigen - metabolism Cells, Cultured Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Chemokine CCL2 - physiology Colitis - chemically induced Colitis - genetics Colitis - metabolism Dextran Sulfate Enterococcus faecalis - immunology Female Flow Cytometry Homeostasis Inflammation - metabolism Interleukin-10 - genetics Interleukin-10 - metabolism Intestines - metabolism Intestines - pathology Macrophage Activation - immunology Macrophages - classification Macrophages - cytology Macrophages - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha - metabolism
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