Matrix metalloproteinase-3 contributes to vulnerability of the nigral dopaminergic neurons

Dopamine(DA)rgic neurons are particularly vulnerable due to the presence of oxidative stress-inducing molecules such as DA, tetrahydrobiopterin, iron and tyrosine hydroxylase (TH). We have recently observed that matrix metalloproteinase-3 (MMP-3) is involved in degeneration of DArgic neurons. In the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurochemistry international 2010, Vol.56 (1), p.161-167
Hauptverfasser:	Kim, Sung Tae, Kim, Eun-Mee, Choi, Ji Hyun, Son, Hyo Jin, Ji, In Jung, Joh, Tong H., Chung, Sun Ju, Hwang, Onyou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Count Cells, Cultured Corpus Striatum - metabolism Cytoprotection - drug effects Cytoprotection - physiology Dendrites - enzymology Dendrites - pathology Disease Models, Animal Dopamine - metabolism Dopaminergic neuron Down-Regulation - genetics Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism Knockout Male Matrix Metalloproteinase 3 - genetics Matrix metalloproteinase-3 Mice Mice, Inbred C57BL Mice, Knockout Nerve Degeneration - enzymology Nerve Degeneration - pathology Nerve Degeneration - physiopathology Neurons - enzymology Neurons - pathology Parkinson Disease - enzymology Parkinson Disease - pathology Parkinson Disease - physiopathology Substantia nigra Substantia Nigra - enzymology Substantia Nigra - pathology Substantia Nigra - physiopathology Tyrosine 3-Monooxygenase - metabolism Tyrosine hydroxylase Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!