Des‐(1–3)‐IGF‐I, an insulin‐like growth factor analog used to mimic a potential IGF‐II autocrine loop, promotes the differentiation of human colon‐carcinoma cells

HT29‐D4 human colon‐carcinoma cells have been shown to secrete insulin‐like growth factor (IGF)‐II and to simultaneously express type‐I IGF receptors. However, the sequestration of IGF‐II by several molecular forms of IGF‐binding proteins (IGFBP) in the culture medium prevents the establishment of a...

Ausführliche Beschreibung