Zolpidem increases bladder capacity and decreases urine excretion in rats
Aims To clarify the effects of zolpidem, a γ‐aminobutyric acid (GABA)A receptor agonist, on bladder function, and urine production, we investigated the effects of zolpidem administration on bladder overactivity induced by cerebral infarction (CI) and on urine excretion increased by water overloading...
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| Veröffentlicht in: | Neurourology and urodynamics 2010-04, Vol.29 (4), p.587-591 |
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| creator | Yokoyama, Osamu Matsuta, Yosuke Yanai-Inamura, Hiroko Watanabe, Mai Ohtake, Akiyoshi Suzuki, Masanori Sasamata, Masao |
| description | Aims
To clarify the effects of zolpidem, a γ‐aminobutyric acid (GABA)A receptor agonist, on bladder function, and urine production, we investigated the effects of zolpidem administration on bladder overactivity induced by cerebral infarction (CI) and on urine excretion increased by water overloading in Wistar rats.
Methods
CI was induced by left middle cerebral artery occlusion. The effects on bladder function of zolpidem alone or in combination with the GABAA receptor antagonist bicuculline, were then examined in the CI rats using cystometry. The antidiuretic effect of zolpidem was investigated in water‐loaded and Brattleboro rats (genetically vasopressin‐deficient). Blood samples were collected from water‐loaded rats to determine the aldosterone level 1 and 6 hr after zolpidem administration.
Results
Zolpidem increased bladder capacity dose‐dependently, but had no significant effect on bladder contraction pressure in CI rats. Bicuculline dose‐dependently inhibited zolpidem‐induced increases in bladder capacity without affecting bladder contraction pressure. Zolpidem dose‐dependently decreased the volume of urine excreted in water‐loaded and Brattleboro rats. Compared with the control group, zolpidem significantly increased the aldosterone concentration in the plasma of water‐loaded rats 1 hr after administration.
Conclusions
Zolpidem increased bladder capacity via a GABAergic mechanism in CI rats, and suppressed urine excretion via a pathway that was not through activation of vasopressin V2 receptors in water‐loaded and Brattleboro rats. These results suggest that zolpidem may improve nocturia via an increase in bladder capacity and a decrease in urine excretion. Neurourol. Urodynam. 29:587–591, 2010. © 2009 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/nau.20797 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733934263</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733934263</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4287-df6dd820770678ad13f2c41b0ebf39a92b61a350322533503cb16046bda5ecbb3</originalsourceid><addsrcrecordid>eNp1kEtLw0AUhQdRtD4W_gHJTlzEziOZSZalaC2ILlQqboZ53MBoXs4k2P57o6m6cnW43O8c7j0InRJ8STCm01r1lxSLXOygCUkpjrkQYhdNsGAspgkXB-gwhFeMccaSfB8dkFxwLNJsgpYvTdk6C1XkauNBBQiRLpW14COjWmVct4lUbSMLP-veuxoiWA9z55p6MEZedeEY7RWqDHCy1SP0dH31OL-Jb-8Xy_nsNjYJzURsC25tNlwrMBeZsoQV1CREY9AFy1VONSeKpZhRmrIvNZpwnHBtVQpGa3aEzsfc1jfvPYROVi4YKEtVQ9MHOfycs4RyNpAXI2l8E4KHQrbeVcpvJMHyqzg5FCe_ixvYs21qryuwf-S2qQGYjsCHK2Hzf5K8mz39RMajw4UO1r8O5d8kF0ykcnW3kA9i_pikq0w-s08_AoaF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733934263</pqid></control><display><type>article</type><title>Zolpidem increases bladder capacity and decreases urine excretion in rats</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Yokoyama, Osamu ; Matsuta, Yosuke ; Yanai-Inamura, Hiroko ; Watanabe, Mai ; Ohtake, Akiyoshi ; Suzuki, Masanori ; Sasamata, Masao</creator><creatorcontrib>Yokoyama, Osamu ; Matsuta, Yosuke ; Yanai-Inamura, Hiroko ; Watanabe, Mai ; Ohtake, Akiyoshi ; Suzuki, Masanori ; Sasamata, Masao</creatorcontrib><description>Aims
To clarify the effects of zolpidem, a γ‐aminobutyric acid (GABA)A receptor agonist, on bladder function, and urine production, we investigated the effects of zolpidem administration on bladder overactivity induced by cerebral infarction (CI) and on urine excretion increased by water overloading in Wistar rats.
Methods
CI was induced by left middle cerebral artery occlusion. The effects on bladder function of zolpidem alone or in combination with the GABAA receptor antagonist bicuculline, were then examined in the CI rats using cystometry. The antidiuretic effect of zolpidem was investigated in water‐loaded and Brattleboro rats (genetically vasopressin‐deficient). Blood samples were collected from water‐loaded rats to determine the aldosterone level 1 and 6 hr after zolpidem administration.
Results
Zolpidem increased bladder capacity dose‐dependently, but had no significant effect on bladder contraction pressure in CI rats. Bicuculline dose‐dependently inhibited zolpidem‐induced increases in bladder capacity without affecting bladder contraction pressure. Zolpidem dose‐dependently decreased the volume of urine excreted in water‐loaded and Brattleboro rats. Compared with the control group, zolpidem significantly increased the aldosterone concentration in the plasma of water‐loaded rats 1 hr after administration.
Conclusions
Zolpidem increased bladder capacity via a GABAergic mechanism in CI rats, and suppressed urine excretion via a pathway that was not through activation of vasopressin V2 receptors in water‐loaded and Brattleboro rats. These results suggest that zolpidem may improve nocturia via an increase in bladder capacity and a decrease in urine excretion. Neurourol. Urodynam. 29:587–591, 2010. © 2009 Wiley‐Liss, Inc.</description><identifier>ISSN: 0733-2467</identifier><identifier>EISSN: 1520-6777</identifier><identifier>DOI: 10.1002/nau.20797</identifier><identifier>PMID: 19760758</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aldosterone - blood ; Animals ; Bicuculline - pharmacology ; bladder capacity ; Cerebral Infarction - complications ; Cerebral Infarction - physiopathology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Female ; GABA Agonists - administration & dosage ; GABA Agonists - pharmacology ; GABA Antagonists - pharmacology ; Infarction, Middle Cerebral Artery - complications ; Injections, Intravenous ; nocturia ; nocturnal polyuria ; Pyridines - administration & dosage ; Pyridines - pharmacology ; Rats ; Rats, Brattleboro ; Rats, Sprague-Dawley ; Rats, Wistar ; Time Factors ; Urinary Bladder - drug effects ; Urinary Bladder - physiopathology ; Urinary Bladder, Overactive - drug therapy ; Urinary Bladder, Overactive - etiology ; Urinary Bladder, Overactive - physiopathology ; Urination - drug effects ; urine excretion ; Urodynamics ; zolpidem</subject><ispartof>Neurourology and urodynamics, 2010-04, Vol.29 (4), p.587-591</ispartof><rights>Copyright © 2009 Wiley‐Liss, Inc.</rights><rights>(c) 2009 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4287-df6dd820770678ad13f2c41b0ebf39a92b61a350322533503cb16046bda5ecbb3</citedby><cites>FETCH-LOGICAL-c4287-df6dd820770678ad13f2c41b0ebf39a92b61a350322533503cb16046bda5ecbb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fnau.20797$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fnau.20797$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19760758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yokoyama, Osamu</creatorcontrib><creatorcontrib>Matsuta, Yosuke</creatorcontrib><creatorcontrib>Yanai-Inamura, Hiroko</creatorcontrib><creatorcontrib>Watanabe, Mai</creatorcontrib><creatorcontrib>Ohtake, Akiyoshi</creatorcontrib><creatorcontrib>Suzuki, Masanori</creatorcontrib><creatorcontrib>Sasamata, Masao</creatorcontrib><title>Zolpidem increases bladder capacity and decreases urine excretion in rats</title><title>Neurourology and urodynamics</title><addtitle>Neurourol. Urodyn</addtitle><description>Aims
To clarify the effects of zolpidem, a γ‐aminobutyric acid (GABA)A receptor agonist, on bladder function, and urine production, we investigated the effects of zolpidem administration on bladder overactivity induced by cerebral infarction (CI) and on urine excretion increased by water overloading in Wistar rats.
Methods
CI was induced by left middle cerebral artery occlusion. The effects on bladder function of zolpidem alone or in combination with the GABAA receptor antagonist bicuculline, were then examined in the CI rats using cystometry. The antidiuretic effect of zolpidem was investigated in water‐loaded and Brattleboro rats (genetically vasopressin‐deficient). Blood samples were collected from water‐loaded rats to determine the aldosterone level 1 and 6 hr after zolpidem administration.
Results
Zolpidem increased bladder capacity dose‐dependently, but had no significant effect on bladder contraction pressure in CI rats. Bicuculline dose‐dependently inhibited zolpidem‐induced increases in bladder capacity without affecting bladder contraction pressure. Zolpidem dose‐dependently decreased the volume of urine excreted in water‐loaded and Brattleboro rats. Compared with the control group, zolpidem significantly increased the aldosterone concentration in the plasma of water‐loaded rats 1 hr after administration.
Conclusions
Zolpidem increased bladder capacity via a GABAergic mechanism in CI rats, and suppressed urine excretion via a pathway that was not through activation of vasopressin V2 receptors in water‐loaded and Brattleboro rats. These results suggest that zolpidem may improve nocturia via an increase in bladder capacity and a decrease in urine excretion. Neurourol. Urodynam. 29:587–591, 2010. © 2009 Wiley‐Liss, Inc.</description><subject>Aldosterone - blood</subject><subject>Animals</subject><subject>Bicuculline - pharmacology</subject><subject>bladder capacity</subject><subject>Cerebral Infarction - complications</subject><subject>Cerebral Infarction - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>GABA Agonists - administration & dosage</subject><subject>GABA Agonists - pharmacology</subject><subject>GABA Antagonists - pharmacology</subject><subject>Infarction, Middle Cerebral Artery - complications</subject><subject>Injections, Intravenous</subject><subject>nocturia</subject><subject>nocturnal polyuria</subject><subject>Pyridines - administration & dosage</subject><subject>Pyridines - pharmacology</subject><subject>Rats</subject><subject>Rats, Brattleboro</subject><subject>Rats, Sprague-Dawley</subject><subject>Rats, Wistar</subject><subject>Time Factors</subject><subject>Urinary Bladder - drug effects</subject><subject>Urinary Bladder - physiopathology</subject><subject>Urinary Bladder, Overactive - drug therapy</subject><subject>Urinary Bladder, Overactive - etiology</subject><subject>Urinary Bladder, Overactive - physiopathology</subject><subject>Urination - drug effects</subject><subject>urine excretion</subject><subject>Urodynamics</subject><subject>zolpidem</subject><issn>0733-2467</issn><issn>1520-6777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLw0AUhQdRtD4W_gHJTlzEziOZSZalaC2ILlQqboZ53MBoXs4k2P57o6m6cnW43O8c7j0InRJ8STCm01r1lxSLXOygCUkpjrkQYhdNsGAspgkXB-gwhFeMccaSfB8dkFxwLNJsgpYvTdk6C1XkauNBBQiRLpW14COjWmVct4lUbSMLP-veuxoiWA9z55p6MEZedeEY7RWqDHCy1SP0dH31OL-Jb-8Xy_nsNjYJzURsC25tNlwrMBeZsoQV1CREY9AFy1VONSeKpZhRmrIvNZpwnHBtVQpGa3aEzsfc1jfvPYROVi4YKEtVQ9MHOfycs4RyNpAXI2l8E4KHQrbeVcpvJMHyqzg5FCe_ixvYs21qryuwf-S2qQGYjsCHK2Hzf5K8mz39RMajw4UO1r8O5d8kF0ykcnW3kA9i_pikq0w-s08_AoaF</recordid><startdate>201004</startdate><enddate>201004</enddate><creator>Yokoyama, Osamu</creator><creator>Matsuta, Yosuke</creator><creator>Yanai-Inamura, Hiroko</creator><creator>Watanabe, Mai</creator><creator>Ohtake, Akiyoshi</creator><creator>Suzuki, Masanori</creator><creator>Sasamata, Masao</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201004</creationdate><title>Zolpidem increases bladder capacity and decreases urine excretion in rats</title><author>Yokoyama, Osamu ; Matsuta, Yosuke ; Yanai-Inamura, Hiroko ; Watanabe, Mai ; Ohtake, Akiyoshi ; Suzuki, Masanori ; Sasamata, Masao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4287-df6dd820770678ad13f2c41b0ebf39a92b61a350322533503cb16046bda5ecbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aldosterone - blood</topic><topic>Animals</topic><topic>Bicuculline - pharmacology</topic><topic>bladder capacity</topic><topic>Cerebral Infarction - complications</topic><topic>Cerebral Infarction - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>GABA Agonists - administration & dosage</topic><topic>GABA Agonists - pharmacology</topic><topic>GABA Antagonists - pharmacology</topic><topic>Infarction, Middle Cerebral Artery - complications</topic><topic>Injections, Intravenous</topic><topic>nocturia</topic><topic>nocturnal polyuria</topic><topic>Pyridines - administration & dosage</topic><topic>Pyridines - pharmacology</topic><topic>Rats</topic><topic>Rats, Brattleboro</topic><topic>Rats, Sprague-Dawley</topic><topic>Rats, Wistar</topic><topic>Time Factors</topic><topic>Urinary Bladder - drug effects</topic><topic>Urinary Bladder - physiopathology</topic><topic>Urinary Bladder, Overactive - drug therapy</topic><topic>Urinary Bladder, Overactive - etiology</topic><topic>Urinary Bladder, Overactive - physiopathology</topic><topic>Urination - drug effects</topic><topic>urine excretion</topic><topic>Urodynamics</topic><topic>zolpidem</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yokoyama, Osamu</creatorcontrib><creatorcontrib>Matsuta, Yosuke</creatorcontrib><creatorcontrib>Yanai-Inamura, Hiroko</creatorcontrib><creatorcontrib>Watanabe, Mai</creatorcontrib><creatorcontrib>Ohtake, Akiyoshi</creatorcontrib><creatorcontrib>Suzuki, Masanori</creatorcontrib><creatorcontrib>Sasamata, Masao</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurourology and urodynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yokoyama, Osamu</au><au>Matsuta, Yosuke</au><au>Yanai-Inamura, Hiroko</au><au>Watanabe, Mai</au><au>Ohtake, Akiyoshi</au><au>Suzuki, Masanori</au><au>Sasamata, Masao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zolpidem increases bladder capacity and decreases urine excretion in rats</atitle><jtitle>Neurourology and urodynamics</jtitle><addtitle>Neurourol. Urodyn</addtitle><date>2010-04</date><risdate>2010</risdate><volume>29</volume><issue>4</issue><spage>587</spage><epage>591</epage><pages>587-591</pages><issn>0733-2467</issn><eissn>1520-6777</eissn><abstract>Aims
To clarify the effects of zolpidem, a γ‐aminobutyric acid (GABA)A receptor agonist, on bladder function, and urine production, we investigated the effects of zolpidem administration on bladder overactivity induced by cerebral infarction (CI) and on urine excretion increased by water overloading in Wistar rats.
Methods
CI was induced by left middle cerebral artery occlusion. The effects on bladder function of zolpidem alone or in combination with the GABAA receptor antagonist bicuculline, were then examined in the CI rats using cystometry. The antidiuretic effect of zolpidem was investigated in water‐loaded and Brattleboro rats (genetically vasopressin‐deficient). Blood samples were collected from water‐loaded rats to determine the aldosterone level 1 and 6 hr after zolpidem administration.
Results
Zolpidem increased bladder capacity dose‐dependently, but had no significant effect on bladder contraction pressure in CI rats. Bicuculline dose‐dependently inhibited zolpidem‐induced increases in bladder capacity without affecting bladder contraction pressure. Zolpidem dose‐dependently decreased the volume of urine excreted in water‐loaded and Brattleboro rats. Compared with the control group, zolpidem significantly increased the aldosterone concentration in the plasma of water‐loaded rats 1 hr after administration.
Conclusions
Zolpidem increased bladder capacity via a GABAergic mechanism in CI rats, and suppressed urine excretion via a pathway that was not through activation of vasopressin V2 receptors in water‐loaded and Brattleboro rats. These results suggest that zolpidem may improve nocturia via an increase in bladder capacity and a decrease in urine excretion. Neurourol. Urodynam. 29:587–591, 2010. © 2009 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19760758</pmid><doi>10.1002/nau.20797</doi><tpages>5</tpages></addata></record> |
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| subjects | Aldosterone - blood Animals Bicuculline - pharmacology bladder capacity Cerebral Infarction - complications Cerebral Infarction - physiopathology Disease Models, Animal Dose-Response Relationship, Drug Drug Therapy, Combination Female GABA Agonists - administration & dosage GABA Agonists - pharmacology GABA Antagonists - pharmacology Infarction, Middle Cerebral Artery - complications Injections, Intravenous nocturia nocturnal polyuria Pyridines - administration & dosage Pyridines - pharmacology Rats Rats, Brattleboro Rats, Sprague-Dawley Rats, Wistar Time Factors Urinary Bladder - drug effects Urinary Bladder - physiopathology Urinary Bladder, Overactive - drug therapy Urinary Bladder, Overactive - etiology Urinary Bladder, Overactive - physiopathology Urination - drug effects urine excretion Urodynamics zolpidem |
| title | Zolpidem increases bladder capacity and decreases urine excretion in rats |
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