Preparation of syn-Tertiary Homoallylic Alcohols Utilizing Allenyltitanocenes Generated by Reductive Titanation of γ-Trimethylsilylpropargylic Carbonates

Preparation of syn-Tertiary Homoallylic Alcohols Utilizing Allenyltitanocenes Generated by Reductive Titanation of γ-Trimethylsilylpropargylic Carbonates

syn-Tertiary homoallylic alcohols were obtained by the reaction of α-silylallenyltitanocenes generated by the reductive titanation of γ-silylpropargylic carbonates with Cp2Ti[P(OEt)3]2 with ketones and following desilylation and partial hydrogenation. High diastereoselectivity was observed when arom...

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Veröffentlicht in:Organic letters 2010-05, Vol.12 (9), p.1968-1971
Hauptverfasser: Yatsumonji, Yasutaka, Sugita, Takenori, Tsubouchi, Akira, Takeda, Takeshi
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container_end_page 1971
container_issue 9
container_start_page 1968
container_title Organic letters
container_volume 12
creator Yatsumonji, Yasutaka
Sugita, Takenori
Tsubouchi, Akira
Takeda, Takeshi
description syn-Tertiary homoallylic alcohols were obtained by the reaction of α-silylallenyltitanocenes generated by the reductive titanation of γ-silylpropargylic carbonates with Cp2Ti[P(OEt)3]2 with ketones and following desilylation and partial hydrogenation. High diastereoselectivity was observed when aromatic and α,β-unsaturated ketones were employed.
doi_str_mv 10.1021/ol100395n
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title Preparation of syn-Tertiary Homoallylic Alcohols Utilizing Allenyltitanocenes Generated by Reductive Titanation of γ-Trimethylsilylpropargylic Carbonates
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