Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy
Background: This double‐blinded study aimed at evaluating and comparing the effects of magnesium and lidocaine on pain, analgesic requirements, bowel function, and quality of sleep in patients undergoing a laparoscopic cholecystectomy (LC). Methods: Patients were randomized into three groups (n=40 e...
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| Veröffentlicht in: | Acta anaesthesiologica Scandinavica 2010-05, Vol.54 (5), p.549-556 |
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| description | Background: This double‐blinded study aimed at evaluating and comparing the effects of magnesium and lidocaine on pain, analgesic requirements, bowel function, and quality of sleep in patients undergoing a laparoscopic cholecystectomy (LC).
Methods: Patients were randomized into three groups (n=40 each). Group M received magnesium sulfate 50 mg/kg intravenously (i.v.), followed by 25 mg/kg/h i.v., group L received lidocaine 2 mg/kg i.v., followed by 2 mg/kg/h i.v., and group P received saline i.v. Bolus doses were given over 15 min before induction of anesthesia, followed by an i.v. infusion through the end of surgery. Intraoperative fentanyl consumption and averaged end‐tidal sevoflurane concentration were recorded. Abdominal and shoulder pain were evaluated up to 24 h using a visual analog scale (VAS). Morphine consumption was recorded at 2 and 24 h, together with quality of sleep and time of first flatus.
Results: Lidocaine or magnesium reduced anesthetic requirements (P |
| doi_str_mv | 10.1111/j.1399-6576.2009.02165.x |
| format | Article |
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Methods: Patients were randomized into three groups (n=40 each). Group M received magnesium sulfate 50 mg/kg intravenously (i.v.), followed by 25 mg/kg/h i.v., group L received lidocaine 2 mg/kg i.v., followed by 2 mg/kg/h i.v., and group P received saline i.v. Bolus doses were given over 15 min before induction of anesthesia, followed by an i.v. infusion through the end of surgery. Intraoperative fentanyl consumption and averaged end‐tidal sevoflurane concentration were recorded. Abdominal and shoulder pain were evaluated up to 24 h using a visual analog scale (VAS). Morphine consumption was recorded at 2 and 24 h, together with quality of sleep and time of first flatus.
Results: Lidocaine or magnesium reduced anesthetic requirements (P<0.01), pain scores (P<0.05), and morphine consumption (P<0.001) relative to the control group. Lidocaine resulted in lower morphine consumption at 2 h [4.9 ± 2.3 vs. 6.8 ± 2.8 (P<0.05)] and lower abdominal VAS scores compared with magnesium (1.8 ± 0.8 vs. 3.2 ± 0.9, 2.2 ± 1 vs. 3.6 ± 1.6, and 2.1 ± 1.4 vs. 3.3 ± 1.9) at 2, 6, and 12 h, respectively (P<0.05). Lidocaine was associated with earlier return of bowel function and magnesium was associated with better sleep quality (P<0.05).
Conclusion: I.v. lidocaine and magnesium improved post‐operative analgesia and reduced intraoperative and post‐operative opioid requirements in patients undergoing LC. The improvement of quality of recovery might facilitate rapid hospital discharge.]]></description><identifier>ISSN: 0001-5172</identifier><identifier>EISSN: 1399-6576</identifier><identifier>DOI: 10.1111/j.1399-6576.2009.02165.x</identifier><identifier>PMID: 19919581</identifier><identifier>CODEN: AANEAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject><![CDATA[Adult ; Analgesics, Opioid - administration & dosage ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthetics - administration & dosage ; Anesthetics, Inhalation ; Biological and medical sciences ; Cholecystectomy, Laparoscopic - methods ; Clinical Protocols ; Double-Blind Method ; Female ; Fentanyl - administration & dosage ; Humans ; Lidocaine - administration & dosage ; Magnesium Sulfate - administration & dosage ; Male ; Medical sciences ; Methyl Ethers ; Pain Measurement ; Pain, Postoperative - prevention & control ; Prospective Studies ; Time Factors ; Treatment Outcome]]></subject><ispartof>Acta anaesthesiologica Scandinavica, 2010-05, Vol.54 (5), p.549-556</ispartof><rights>2009 The Authors. Journal compilation © 2009 The Acta Anaesthesiologica Scandinavica Foundation</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4865-a18e493e2e516a7236c785436cb89e720054367bf3967e166f40b80836cddf2d3</citedby><cites>FETCH-LOGICAL-c4865-a18e493e2e516a7236c785436cb89e720054367bf3967e166f40b80836cddf2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-6576.2009.02165.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-6576.2009.02165.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22551558$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19919581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SAADAWY, I. M.</creatorcontrib><creatorcontrib>KAKI, A. M.</creatorcontrib><creatorcontrib>ABD EL LATIF, A. A.</creatorcontrib><creatorcontrib>ABD-ELMAKSOUD, A. M.</creatorcontrib><creatorcontrib>TOLBA, O. M.</creatorcontrib><title>Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy</title><title>Acta anaesthesiologica Scandinavica</title><addtitle>Acta Anaesthesiol Scand</addtitle><description><![CDATA[Background: This double‐blinded study aimed at evaluating and comparing the effects of magnesium and lidocaine on pain, analgesic requirements, bowel function, and quality of sleep in patients undergoing a laparoscopic cholecystectomy (LC).
Methods: Patients were randomized into three groups (n=40 each). Group M received magnesium sulfate 50 mg/kg intravenously (i.v.), followed by 25 mg/kg/h i.v., group L received lidocaine 2 mg/kg i.v., followed by 2 mg/kg/h i.v., and group P received saline i.v. Bolus doses were given over 15 min before induction of anesthesia, followed by an i.v. infusion through the end of surgery. Intraoperative fentanyl consumption and averaged end‐tidal sevoflurane concentration were recorded. Abdominal and shoulder pain were evaluated up to 24 h using a visual analog scale (VAS). Morphine consumption was recorded at 2 and 24 h, together with quality of sleep and time of first flatus.
Results: Lidocaine or magnesium reduced anesthetic requirements (P<0.01), pain scores (P<0.05), and morphine consumption (P<0.001) relative to the control group. Lidocaine resulted in lower morphine consumption at 2 h [4.9 ± 2.3 vs. 6.8 ± 2.8 (P<0.05)] and lower abdominal VAS scores compared with magnesium (1.8 ± 0.8 vs. 3.2 ± 0.9, 2.2 ± 1 vs. 3.6 ± 1.6, and 2.1 ± 1.4 vs. 3.3 ± 1.9) at 2, 6, and 12 h, respectively (P<0.05). Lidocaine was associated with earlier return of bowel function and magnesium was associated with better sleep quality (P<0.05).
Conclusion: I.v. lidocaine and magnesium improved post‐operative analgesia and reduced intraoperative and post‐operative opioid requirements in patients undergoing LC. The improvement of quality of recovery might facilitate rapid hospital discharge.]]></description><subject>Adult</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthetics - administration & dosage</subject><subject>Anesthetics, Inhalation</subject><subject>Biological and medical sciences</subject><subject>Cholecystectomy, Laparoscopic - methods</subject><subject>Clinical Protocols</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Fentanyl - administration & dosage</subject><subject>Humans</subject><subject>Lidocaine - administration & dosage</subject><subject>Magnesium Sulfate - administration & dosage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methyl Ethers</subject><subject>Pain Measurement</subject><subject>Pain, Postoperative - prevention & control</subject><subject>Prospective Studies</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0001-5172</issn><issn>1399-6576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtvEzEURi0EomnhLyBvEKsZ_BjbYyQWUUVbpAiEUujSuvFcF4d5hHECyb_HQ6KwxZvra5_Pj0MI5azkebxdl1xaW2hldCkYsyUTXKty_4TMzhtPyYwxxgvFjbgglymtcysra5-TC24tt6rmM_JlEZvBQ-yR_kol7eCxxxR33TuKIaDf0qGn0EP7mFeBQtjiSIG2sIFxSH7YRE_996FFf0jbjA_d4QV5FqBN-PJUr8jXmw_313fF4vPtx-v5ovBVrVUBvMbKShSouAYjpPamVlUuq9qiyb-aGrMK0mqDXOtQsVXN6gw0TRCNvCJvjuduxuHnDtPWdTF5bFvocdglZ6S0UjKtMlkfSZ_fnEYMbjPGDsaD48xNPt3aTdrcpM1NPt1fn26fo69Ol-xWHTb_gieBGXh9AiB5aMMIvY_pzAmhFFeqztz7I_c7tnj47we4-Xw5zXK-OOZj9rw_52H84bSRRrmHT7du-W0p9P3Ng1PyD1r7nzk</recordid><startdate>201005</startdate><enddate>201005</enddate><creator>SAADAWY, I. M.</creator><creator>KAKI, A. M.</creator><creator>ABD EL LATIF, A. A.</creator><creator>ABD-ELMAKSOUD, A. M.</creator><creator>TOLBA, O. M.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201005</creationdate><title>Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy</title><author>SAADAWY, I. M. ; KAKI, A. M. ; ABD EL LATIF, A. A. ; ABD-ELMAKSOUD, A. M. ; TOLBA, O. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4865-a18e493e2e516a7236c785436cb89e720054367bf3967e166f40b80836cddf2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthetics - administration & dosage</topic><topic>Anesthetics, Inhalation</topic><topic>Biological and medical sciences</topic><topic>Cholecystectomy, Laparoscopic - methods</topic><topic>Clinical Protocols</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Fentanyl - administration & dosage</topic><topic>Humans</topic><topic>Lidocaine - administration & dosage</topic><topic>Magnesium Sulfate - administration & dosage</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methyl Ethers</topic><topic>Pain Measurement</topic><topic>Pain, Postoperative - prevention & control</topic><topic>Prospective Studies</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SAADAWY, I. M.</creatorcontrib><creatorcontrib>KAKI, A. M.</creatorcontrib><creatorcontrib>ABD EL LATIF, A. A.</creatorcontrib><creatorcontrib>ABD-ELMAKSOUD, A. M.</creatorcontrib><creatorcontrib>TOLBA, O. M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta anaesthesiologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SAADAWY, I. M.</au><au>KAKI, A. M.</au><au>ABD EL LATIF, A. A.</au><au>ABD-ELMAKSOUD, A. M.</au><au>TOLBA, O. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy</atitle><jtitle>Acta anaesthesiologica Scandinavica</jtitle><addtitle>Acta Anaesthesiol Scand</addtitle><date>2010-05</date><risdate>2010</risdate><volume>54</volume><issue>5</issue><spage>549</spage><epage>556</epage><pages>549-556</pages><issn>0001-5172</issn><eissn>1399-6576</eissn><coden>AANEAB</coden><abstract><![CDATA[Background: This double‐blinded study aimed at evaluating and comparing the effects of magnesium and lidocaine on pain, analgesic requirements, bowel function, and quality of sleep in patients undergoing a laparoscopic cholecystectomy (LC).
Methods: Patients were randomized into three groups (n=40 each). Group M received magnesium sulfate 50 mg/kg intravenously (i.v.), followed by 25 mg/kg/h i.v., group L received lidocaine 2 mg/kg i.v., followed by 2 mg/kg/h i.v., and group P received saline i.v. Bolus doses were given over 15 min before induction of anesthesia, followed by an i.v. infusion through the end of surgery. Intraoperative fentanyl consumption and averaged end‐tidal sevoflurane concentration were recorded. Abdominal and shoulder pain were evaluated up to 24 h using a visual analog scale (VAS). Morphine consumption was recorded at 2 and 24 h, together with quality of sleep and time of first flatus.
Results: Lidocaine or magnesium reduced anesthetic requirements (P<0.01), pain scores (P<0.05), and morphine consumption (P<0.001) relative to the control group. Lidocaine resulted in lower morphine consumption at 2 h [4.9 ± 2.3 vs. 6.8 ± 2.8 (P<0.05)] and lower abdominal VAS scores compared with magnesium (1.8 ± 0.8 vs. 3.2 ± 0.9, 2.2 ± 1 vs. 3.6 ± 1.6, and 2.1 ± 1.4 vs. 3.3 ± 1.9) at 2, 6, and 12 h, respectively (P<0.05). Lidocaine was associated with earlier return of bowel function and magnesium was associated with better sleep quality (P<0.05).
Conclusion: I.v. lidocaine and magnesium improved post‐operative analgesia and reduced intraoperative and post‐operative opioid requirements in patients undergoing LC. The improvement of quality of recovery might facilitate rapid hospital discharge.]]></abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19919581</pmid><doi>10.1111/j.1399-6576.2009.02165.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Analgesics, Opioid - administration & dosage Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics - administration & dosage Anesthetics, Inhalation Biological and medical sciences Cholecystectomy, Laparoscopic - methods Clinical Protocols Double-Blind Method Female Fentanyl - administration & dosage Humans Lidocaine - administration & dosage Magnesium Sulfate - administration & dosage Male Medical sciences Methyl Ethers Pain Measurement Pain, Postoperative - prevention & control Prospective Studies Time Factors Treatment Outcome |
| title | Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy |
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