Dual Time Point C-11 Acetate PET Imaging Can Potentially Distinguish Focal Nodular Hyperplasia From Primary Hepatocellular Carcinoma
C-11 acetate positron emission tomography (PET) is known to have high sensitivity in detecting hepatocellular carcinoma. However, one of the shortcomings of C-11 acetate PET in the diagnosis of hepatocellular carcinoma is that C-11 acetate also accumulates in focal nodular hyperplasia, which makes i...
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| Veröffentlicht in: | Clinical nuclear medicine 2009-12, Vol.34 (12), p.874-877 |
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| creator | Huo, Li Wu, Zhanhong Zhuang, Hongming Fu, Zhe Dang, Yonghong |
| description | C-11 acetate positron emission tomography (PET) is known to have high sensitivity in detecting hepatocellular carcinoma. However, one of the shortcomings of C-11 acetate PET in the diagnosis of hepatocellular carcinoma is that C-11 acetate also accumulates in focal nodular hyperplasia, which makes it challenging to distinguish hepatocellular carcinoma form focal nodular hyperplasia when a conventional single time point PET imaging method is used. Two patients with suspected hepatocellular carcinoma and negative fluoro-deoxy-glucose PET scans underwent C-11 acetate PET dual time imaging in which both early and delayed images were acquired. One patient was subsequently confirmed having hepatocellular carcinoma while the other had focal nodular hyperplasia. C-11 acetate imaging was positive in both patients. Interestingly, in hepatocellular carcinoma the C-11 acetate activity in the delayed images is higher than in the early images while in focal nodular hyperplasia, the C-11 acetate activity decreased in the delayed image when compared with early images. Our findings suggest that dual time point imaging has potential to improve the diagnostic accuracy of C-11 acetate PET in the diagnosis of hepatocellular carcinoma. |
| doi_str_mv | 10.1097/RLU.0b013e3181bed06e |
| format | Article |
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However, one of the shortcomings of C-11 acetate PET in the diagnosis of hepatocellular carcinoma is that C-11 acetate also accumulates in focal nodular hyperplasia, which makes it challenging to distinguish hepatocellular carcinoma form focal nodular hyperplasia when a conventional single time point PET imaging method is used. Two patients with suspected hepatocellular carcinoma and negative fluoro-deoxy-glucose PET scans underwent C-11 acetate PET dual time imaging in which both early and delayed images were acquired. One patient was subsequently confirmed having hepatocellular carcinoma while the other had focal nodular hyperplasia. C-11 acetate imaging was positive in both patients. Interestingly, in hepatocellular carcinoma the C-11 acetate activity in the delayed images is higher than in the early images while in focal nodular hyperplasia, the C-11 acetate activity decreased in the delayed image when compared with early images. Our findings suggest that dual time point imaging has potential to improve the diagnostic accuracy of C-11 acetate PET in the diagnosis of hepatocellular carcinoma.</description><identifier>ISSN: 0363-9762</identifier><identifier>EISSN: 1536-0229</identifier><identifier>DOI: 10.1097/RLU.0b013e3181bed06e</identifier><identifier>PMID: 20139820</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, Inc</publisher><subject>Acetates ; Carbon ; Carcinoma, Hepatocellular - diagnostic imaging ; Diagnosis, Differential ; Feasibility Studies ; Focal Nodular Hyperplasia - diagnostic imaging ; Humans ; Liver Neoplasms - diagnostic imaging ; Male ; Middle Aged ; Positron-Emission Tomography - methods ; Radiopharmaceuticals ; Reproducibility of Results ; Sensitivity and Specificity</subject><ispartof>Clinical nuclear medicine, 2009-12, Vol.34 (12), p.874-877</ispartof><rights>2009 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3517-d841c9e413d0515653951edf6570a0f4a89a2fc2f8a0e446f7ef3108d18d31a63</citedby><cites>FETCH-LOGICAL-c3517-d841c9e413d0515653951edf6570a0f4a89a2fc2f8a0e446f7ef3108d18d31a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20139820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huo, Li</creatorcontrib><creatorcontrib>Wu, Zhanhong</creatorcontrib><creatorcontrib>Zhuang, Hongming</creatorcontrib><creatorcontrib>Fu, Zhe</creatorcontrib><creatorcontrib>Dang, Yonghong</creatorcontrib><title>Dual Time Point C-11 Acetate PET Imaging Can Potentially Distinguish Focal Nodular Hyperplasia From Primary Hepatocellular Carcinoma</title><title>Clinical nuclear medicine</title><addtitle>Clin Nucl Med</addtitle><description>C-11 acetate positron emission tomography (PET) is known to have high sensitivity in detecting hepatocellular carcinoma. However, one of the shortcomings of C-11 acetate PET in the diagnosis of hepatocellular carcinoma is that C-11 acetate also accumulates in focal nodular hyperplasia, which makes it challenging to distinguish hepatocellular carcinoma form focal nodular hyperplasia when a conventional single time point PET imaging method is used. Two patients with suspected hepatocellular carcinoma and negative fluoro-deoxy-glucose PET scans underwent C-11 acetate PET dual time imaging in which both early and delayed images were acquired. One patient was subsequently confirmed having hepatocellular carcinoma while the other had focal nodular hyperplasia. C-11 acetate imaging was positive in both patients. Interestingly, in hepatocellular carcinoma the C-11 acetate activity in the delayed images is higher than in the early images while in focal nodular hyperplasia, the C-11 acetate activity decreased in the delayed image when compared with early images. Our findings suggest that dual time point imaging has potential to improve the diagnostic accuracy of C-11 acetate PET in the diagnosis of hepatocellular carcinoma.</description><subject>Acetates</subject><subject>Carbon</subject><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Diagnosis, Differential</subject><subject>Feasibility Studies</subject><subject>Focal Nodular Hyperplasia - diagnostic imaging</subject><subject>Humans</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Positron-Emission Tomography - methods</subject><subject>Radiopharmaceuticals</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><issn>0363-9762</issn><issn>1536-0229</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUMFu00AQtRCIhsIfILQ3Tm5nvPbaPlZpQypFUKH0bE3scbOw9prdtarc--FsSAsSc5iRnt57M_OS5CPCBUJdXn7f3F_ADlCyxAp33IHiV8kCC6lSyLL6dbIAqWRalyo7S955_wMAFar8bXKWRVldZbBInq5nMmKrBxZ3Vo9BLFNEcdVyoBChm624HehBjw9iSWOkBB6DJmMO4lr7EPFZ-71Y2Ta6fLXdbMiJ9WFiNxnymsTK2UHcOT2QO4g1TxRsy8b84S3JtXq0A71P3vRkPH94nufJ_epmu1ynm29fbpdXm7SVBZZpV-XY1pyj7KDAQhWyLpC7XhUlEPQ5VTVlfZv1FQHnuepL7iVC1WHVSSQlz5PPJ9_J2V8z-9AM2h_PoZHt7JtSylpChVVk5idm66z3jvtmOv3QIDTH-JsYf_N__FH26XnBvBu4-yt6yfuf76M1gZ3_aeZHds2eyYR9A7EklFmaAdQYG6RHqJS_Afe1keQ</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Huo, Li</creator><creator>Wu, Zhanhong</creator><creator>Zhuang, Hongming</creator><creator>Fu, Zhe</creator><creator>Dang, Yonghong</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200912</creationdate><title>Dual Time Point C-11 Acetate PET Imaging Can Potentially Distinguish Focal Nodular Hyperplasia From Primary Hepatocellular Carcinoma</title><author>Huo, Li ; Wu, Zhanhong ; Zhuang, Hongming ; Fu, Zhe ; Dang, Yonghong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3517-d841c9e413d0515653951edf6570a0f4a89a2fc2f8a0e446f7ef3108d18d31a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acetates</topic><topic>Carbon</topic><topic>Carcinoma, Hepatocellular - diagnostic imaging</topic><topic>Diagnosis, Differential</topic><topic>Feasibility Studies</topic><topic>Focal Nodular Hyperplasia - diagnostic imaging</topic><topic>Humans</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Positron-Emission Tomography - methods</topic><topic>Radiopharmaceuticals</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huo, Li</creatorcontrib><creatorcontrib>Wu, Zhanhong</creatorcontrib><creatorcontrib>Zhuang, Hongming</creatorcontrib><creatorcontrib>Fu, Zhe</creatorcontrib><creatorcontrib>Dang, Yonghong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huo, Li</au><au>Wu, Zhanhong</au><au>Zhuang, Hongming</au><au>Fu, Zhe</au><au>Dang, Yonghong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dual Time Point C-11 Acetate PET Imaging Can Potentially Distinguish Focal Nodular Hyperplasia From Primary Hepatocellular Carcinoma</atitle><jtitle>Clinical nuclear medicine</jtitle><addtitle>Clin Nucl Med</addtitle><date>2009-12</date><risdate>2009</risdate><volume>34</volume><issue>12</issue><spage>874</spage><epage>877</epage><pages>874-877</pages><issn>0363-9762</issn><eissn>1536-0229</eissn><abstract>C-11 acetate positron emission tomography (PET) is known to have high sensitivity in detecting hepatocellular carcinoma. However, one of the shortcomings of C-11 acetate PET in the diagnosis of hepatocellular carcinoma is that C-11 acetate also accumulates in focal nodular hyperplasia, which makes it challenging to distinguish hepatocellular carcinoma form focal nodular hyperplasia when a conventional single time point PET imaging method is used. Two patients with suspected hepatocellular carcinoma and negative fluoro-deoxy-glucose PET scans underwent C-11 acetate PET dual time imaging in which both early and delayed images were acquired. One patient was subsequently confirmed having hepatocellular carcinoma while the other had focal nodular hyperplasia. C-11 acetate imaging was positive in both patients. Interestingly, in hepatocellular carcinoma the C-11 acetate activity in the delayed images is higher than in the early images while in focal nodular hyperplasia, the C-11 acetate activity decreased in the delayed image when compared with early images. Our findings suggest that dual time point imaging has potential to improve the diagnostic accuracy of C-11 acetate PET in the diagnosis of hepatocellular carcinoma.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>20139820</pmid><doi>10.1097/RLU.0b013e3181bed06e</doi><tpages>4</tpages></addata></record> |
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| subjects | Acetates Carbon Carcinoma, Hepatocellular - diagnostic imaging Diagnosis, Differential Feasibility Studies Focal Nodular Hyperplasia - diagnostic imaging Humans Liver Neoplasms - diagnostic imaging Male Middle Aged Positron-Emission Tomography - methods Radiopharmaceuticals Reproducibility of Results Sensitivity and Specificity |
| title | Dual Time Point C-11 Acetate PET Imaging Can Potentially Distinguish Focal Nodular Hyperplasia From Primary Hepatocellular Carcinoma |
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