Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers

There exist two distinct thrombospondin molecules (designated TSP1 and TSP2) which are encoded by separate genes. TSP1 is a trimeric cell surface and extracellular matrix molecule. Sequence comparison reveals that the 2 cysteines involved in interchain disulfide linkage and trimer assembly in TSP1 a...

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Veröffentlicht in:	The Journal of biological chemistry 1992-12, Vol.267 (35), p.24921-24924
Hauptverfasser:	O'ROURKE, K. M, LAHERTY, C. D, DIXIT, V. M
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Analytical, structural and metabolic biochemistry Animals Antibody Specificity Biological and medical sciences Blotting, Western Chromatography, Affinity Cloning, Molecular Cysteine - metabolism Escherichia coli - genetics expression extracellular matrix Fundamental and applied biological sciences. Psychology Genetic Vectors Glycoproteins Immunoassay Lectins - biosynthesis Lectins - genetics Macromolecular Substances Methionine - metabolism Mice Platelet Membrane Glycoproteins - biosynthesis Platelet Membrane Glycoproteins - genetics Proteins Recombinant Fusion Proteins - biosynthesis thrombospondin 1 thrombospondin 2 Thrombospondins Transfection
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