Differential effects of immunophilin-ligands (FK506 and V-10,367) on survival and regeneration of rat retinal ganglion cells in vitro and after optic nerve crush in vivo

Immunophilins belong to the large family of peptidyl-prolyl-cis-trans-isomerases known to be involved in many cellular processes (e.g., protein trafficking and transcriptional regulation). Beside the widespread therapeutic use of ligands of immunophilins as immunosuppressants, it has been shown that...

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Veröffentlicht in:	Journal of neurotrauma 2003-03, Vol.20 (3), p.297-307
Hauptverfasser:	ROSENSTIEL, Philip, SCHRAMM, Peter, ISENMANN, Stefan, BRECHT, Stefan, EICKMEIER, Christian, BÜRGER, Erich, HERDEGEN, Thomas, SIEVERS, Jobst, LUCIUS, Ralph
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biological and medical sciences Cells, Cultured Cyclohexanols - pharmacology Dose-Response Relationship, Drug GAP-43 Protein - metabolism Immunohistochemistry In Situ Nick-End Labeling Medical sciences Nerve Crush Nerve Regeneration - drug effects Neurites - drug effects Neuropharmacology Neuroprotective agent Neuroprotective Agents - pharmacology Optic Nerve Injuries - pathology Optic Nerve Injuries - physiopathology Pharmacology. Drug treatments Pyrans - pharmacology Pyridines - pharmacology Rats Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - pathology Retinal Ganglion Cells - physiology Tacrolimus - administration & dosage Tacrolimus - pharmacology
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