Advances in mast cell biology: new understanding of heterogeneity and function
Mast cells are classically viewed as effector cells of IgE-mediated allergic diseases. However, over the last decade our understanding has been enriched about their roles in host defense, innate and adaptive immune responses, and in homeostatic responses, angiogenesis, wound healing, tissue remodeli...
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| Veröffentlicht in: | Mucosal immunology 2010-03, Vol.3 (2), p.111-128 |
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| container_end_page | 128 |
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| container_title | Mucosal immunology |
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| creator | Moon, T C St Laurent, C D Morris, K E Marcet, C Yoshimura, T Sekar, Y Befus, A D |
| description | Mast cells are classically viewed as effector cells of IgE-mediated allergic diseases. However, over the last decade our understanding has been enriched about their roles in host defense, innate and adaptive immune responses, and in homeostatic responses, angiogenesis, wound healing, tissue remodeling, and immunoregulation. Despite impressive progress, there are large gaps in our understanding of their phenotypic heterogeneity, regulatory mechanisms involved, and functional significance. This review summarizes our knowledge of mast cells in innate and acquired immunity, allergic inflammation and tissue homeostasis, as well as some of the regulatory mechanisms that control mast cell development, phenotypic determination, and function, particularly in the context of mucosal surfaces. |
| doi_str_mv | 10.1038/mi.2009.136 |
| format | Article |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adaptive Immunity Allergology Animals Antibodies Biomedical and Life Sciences Biomedicine Disease Models, Animal Gastroenterology Humans Immunity, Innate Immunology Mast Cells - classification Mast Cells - immunology review |
| title | Advances in mast cell biology: new understanding of heterogeneity and function |
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