Synthesis, characterization and DNA binding studies of new ruthenium(II)bisterpyridine complexes
Two new ruthenium(II) complexes, [Ru(itpy) 2](PF 6) 2, 1 and [Ru(bitpy) 2](PF 6) 2 2, were synthesized and characterized by ESI-Mass, UV-Visible, 1H NMR, fluorescence spectroscopy and cyclic voltammetry. Complex 1 has been characterized crystallographically. Interaction of these complexes with CT-DN...
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| Veröffentlicht in: | European journal of medicinal chemistry 2010, Vol.45 (1), p.284-291 |
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| creator | Sathyaraj, Gopal Weyhermüller, Thomas Nair, Balachandran Unni |
| description | Two new ruthenium(II) complexes, [Ru(itpy)
2](PF
6)
2,
1 and [Ru(bitpy)
2](PF
6)
2
2, were synthesized and characterized by ESI-Mass, UV-Visible,
1H NMR, fluorescence spectroscopy and cyclic voltammetry. Complex
1 has been characterized crystallographically. Interaction of these complexes with CT-DNA has been studied using absorption and CD spectra. Absorption spectral titration and CD spectral measurements show that complex
1 binds with DNA through intercalation. Complex
2 on the other hand shows dual mode of binding to DNA, groove binding as well as intercalation. Photo nuclease activity of these complexes has been studied using agarose gel electrophoresis and both the complexes have been shown to exhibit photonuclease activity. However, complex
1 has been found to show higher DNA cleaving efficiency compared to complex
2.
[Display omitted] Imidazolyl terpyridine complex of Ru(II) binds intercalatively to DNA, while benzimidazolyl terpyridine complex shows dual mode of binding. |
| doi_str_mv | 10.1016/j.ejmech.2009.10.008 |
| format | Article |
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2](PF
6)
2,
1 and [Ru(bitpy)
2](PF
6)
2
2, were synthesized and characterized by ESI-Mass, UV-Visible,
1H NMR, fluorescence spectroscopy and cyclic voltammetry. Complex
1 has been characterized crystallographically. Interaction of these complexes with CT-DNA has been studied using absorption and CD spectra. Absorption spectral titration and CD spectral measurements show that complex
1 binds with DNA through intercalation. Complex
2 on the other hand shows dual mode of binding to DNA, groove binding as well as intercalation. Photo nuclease activity of these complexes has been studied using agarose gel electrophoresis and both the complexes have been shown to exhibit photonuclease activity. However, complex
1 has been found to show higher DNA cleaving efficiency compared to complex
2.
[Display omitted] Imidazolyl terpyridine complex of Ru(II) binds intercalatively to DNA, while benzimidazolyl terpyridine complex shows dual mode of binding.</description><identifier>ISSN: 0223-5234</identifier><identifier>EISSN: 1768-3254</identifier><identifier>DOI: 10.1016/j.ejmech.2009.10.008</identifier><identifier>PMID: 19879670</identifier><identifier>CODEN: EJMCA5</identifier><language>eng</language><publisher>Kidlington: Elsevier Masson SAS</publisher><subject>Absorption ; Animals ; Antineoplastic agents ; Biological and medical sciences ; Cattle ; Circular Dichroism ; Deoxyribonucleases - metabolism ; DNA - chemistry ; DNA - metabolism ; DNA cleavage ; Dual binding ; General aspects ; Medical sciences ; Models, Molecular ; Molecular Conformation ; Nucleic Acid Denaturation ; Organometallic Compounds - chemical synthesis ; Organometallic Compounds - chemistry ; Organometallic Compounds - metabolism ; Pharmacology. Drug treatments ; Pyridines - chemistry ; Ruthenium ; Ruthenium - chemistry ; Terpyridine ; Transition Temperature</subject><ispartof>European journal of medicinal chemistry, 2010, Vol.45 (1), p.284-291</ispartof><rights>2009 Elsevier Masson SAS</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2009 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-915003873d3dcc79c9153edade27c080cdc0b5f2a2689e75f77a66d936c17bb23</citedby><cites>FETCH-LOGICAL-c391t-915003873d3dcc79c9153edade27c080cdc0b5f2a2689e75f77a66d936c17bb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejmech.2009.10.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22375602$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19879670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sathyaraj, Gopal</creatorcontrib><creatorcontrib>Weyhermüller, Thomas</creatorcontrib><creatorcontrib>Nair, Balachandran Unni</creatorcontrib><title>Synthesis, characterization and DNA binding studies of new ruthenium(II)bisterpyridine complexes</title><title>European journal of medicinal chemistry</title><addtitle>Eur J Med Chem</addtitle><description>Two new ruthenium(II) complexes, [Ru(itpy)
2](PF
6)
2,
1 and [Ru(bitpy)
2](PF
6)
2
2, were synthesized and characterized by ESI-Mass, UV-Visible,
1H NMR, fluorescence spectroscopy and cyclic voltammetry. Complex
1 has been characterized crystallographically. Interaction of these complexes with CT-DNA has been studied using absorption and CD spectra. Absorption spectral titration and CD spectral measurements show that complex
1 binds with DNA through intercalation. Complex
2 on the other hand shows dual mode of binding to DNA, groove binding as well as intercalation. Photo nuclease activity of these complexes has been studied using agarose gel electrophoresis and both the complexes have been shown to exhibit photonuclease activity. However, complex
1 has been found to show higher DNA cleaving efficiency compared to complex
2.
[Display omitted] Imidazolyl terpyridine complex of Ru(II) binds intercalatively to DNA, while benzimidazolyl terpyridine complex shows dual mode of binding.</description><subject>Absorption</subject><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Circular Dichroism</subject><subject>Deoxyribonucleases - metabolism</subject><subject>DNA - chemistry</subject><subject>DNA - metabolism</subject><subject>DNA cleavage</subject><subject>Dual binding</subject><subject>General aspects</subject><subject>Medical sciences</subject><subject>Models, Molecular</subject><subject>Molecular Conformation</subject><subject>Nucleic Acid Denaturation</subject><subject>Organometallic Compounds - chemical synthesis</subject><subject>Organometallic Compounds - chemistry</subject><subject>Organometallic Compounds - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyridines - chemistry</subject><subject>Ruthenium</subject><subject>Ruthenium - chemistry</subject><subject>Terpyridine</subject><subject>Transition Temperature</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2P0zAQhi3Eii0L_wChXBAgkTK2mzi-IK2Wj620ggNwNs54Ql0lTtdOYMuvx1UruO1ppFfP6xk9ZuwZhyUHXr_dLmk7EG6WAkDnaAnQPGALruqmlKJaPWQLEEKWlZCrc_Y4pS0AVDXAI3bOdaN0rWDBfnzdh2lDyac3BW5stDhR9H_s5MdQ2OCK958vi9YH58PPIk2z85SKsSsC_S7inJvBz8Or9fp161Nu7vbRZ5QKHIddT3eUnrCzzvaJnp7mBfv-8cO3q-vy5sun9dXlTYlS86nUvAKQjZJOOkSlMQeSnHUkFEID6BDaqhNW1I0mVXVK2bp2WtbIVdsKecFeHt_dxfF2pjSZwSekvreBxjkZJaUWinPI5OpIYhxTitSZXfSDjXvDwRzUmq05qjUHtYc0q82156cFczuQ-186uczAixNgE9q-izagT_-4_Bcq6z9c-u7IUdbxy1M0CT0FJOcj4WTc6O-_5C8QIpng</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Sathyaraj, Gopal</creator><creator>Weyhermüller, Thomas</creator><creator>Nair, Balachandran Unni</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Synthesis, characterization and DNA binding studies of new ruthenium(II)bisterpyridine complexes</title><author>Sathyaraj, Gopal ; Weyhermüller, Thomas ; Nair, Balachandran Unni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-915003873d3dcc79c9153edade27c080cdc0b5f2a2689e75f77a66d936c17bb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Absorption</topic><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Circular Dichroism</topic><topic>Deoxyribonucleases - metabolism</topic><topic>DNA - chemistry</topic><topic>DNA - metabolism</topic><topic>DNA cleavage</topic><topic>Dual binding</topic><topic>General aspects</topic><topic>Medical sciences</topic><topic>Models, Molecular</topic><topic>Molecular Conformation</topic><topic>Nucleic Acid Denaturation</topic><topic>Organometallic Compounds - chemical synthesis</topic><topic>Organometallic Compounds - chemistry</topic><topic>Organometallic Compounds - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyridines - chemistry</topic><topic>Ruthenium</topic><topic>Ruthenium - chemistry</topic><topic>Terpyridine</topic><topic>Transition Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sathyaraj, Gopal</creatorcontrib><creatorcontrib>Weyhermüller, Thomas</creatorcontrib><creatorcontrib>Nair, Balachandran Unni</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sathyaraj, Gopal</au><au>Weyhermüller, Thomas</au><au>Nair, Balachandran Unni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, characterization and DNA binding studies of new ruthenium(II)bisterpyridine complexes</atitle><jtitle>European journal of medicinal chemistry</jtitle><addtitle>Eur J Med Chem</addtitle><date>2010</date><risdate>2010</risdate><volume>45</volume><issue>1</issue><spage>284</spage><epage>291</epage><pages>284-291</pages><issn>0223-5234</issn><eissn>1768-3254</eissn><coden>EJMCA5</coden><abstract>Two new ruthenium(II) complexes, [Ru(itpy)
2](PF
6)
2,
1 and [Ru(bitpy)
2](PF
6)
2
2, were synthesized and characterized by ESI-Mass, UV-Visible,
1H NMR, fluorescence spectroscopy and cyclic voltammetry. Complex
1 has been characterized crystallographically. Interaction of these complexes with CT-DNA has been studied using absorption and CD spectra. Absorption spectral titration and CD spectral measurements show that complex
1 binds with DNA through intercalation. Complex
2 on the other hand shows dual mode of binding to DNA, groove binding as well as intercalation. Photo nuclease activity of these complexes has been studied using agarose gel electrophoresis and both the complexes have been shown to exhibit photonuclease activity. However, complex
1 has been found to show higher DNA cleaving efficiency compared to complex
2.
[Display omitted] Imidazolyl terpyridine complex of Ru(II) binds intercalatively to DNA, while benzimidazolyl terpyridine complex shows dual mode of binding.</abstract><cop>Kidlington</cop><pub>Elsevier Masson SAS</pub><pmid>19879670</pmid><doi>10.1016/j.ejmech.2009.10.008</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0223-5234 |
| ispartof | European journal of medicinal chemistry, 2010, Vol.45 (1), p.284-291 |
| issn | 0223-5234 1768-3254 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733927110 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Absorption Animals Antineoplastic agents Biological and medical sciences Cattle Circular Dichroism Deoxyribonucleases - metabolism DNA - chemistry DNA - metabolism DNA cleavage Dual binding General aspects Medical sciences Models, Molecular Molecular Conformation Nucleic Acid Denaturation Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organometallic Compounds - metabolism Pharmacology. Drug treatments Pyridines - chemistry Ruthenium Ruthenium - chemistry Terpyridine Transition Temperature |
| title | Synthesis, characterization and DNA binding studies of new ruthenium(II)bisterpyridine complexes |
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