Synthesis, spectral characterization and biological evaluation of phosphorylated derivatives of galanthamine

A series of novel phosphorylated derivatives of galanthamine 6–11 and 12–17 were synthesized in two step process with high yields. In the first step galanthamine 1 was reacted with bis (2-chloroethyl) phosphoramidic dichloride 2/4-nitrophenyl phosphorodichloridate 3 in presence of triethylamine (TEA...

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Veröffentlicht in:	European journal of medicinal chemistry 2010, Vol.45 (1), p.203-209
Hauptverfasser:	Koteswara Rao, V., Janardhan Rao, A., Subba Reddy, S., Naga Raju, C., Visweswara Rao, P., Ghosh, S.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial activity Antioxidant activity Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology Bacteria - drug effects Biological and medical sciences Catalase - metabolism Galantamine - analogs & derivatives Galantamine - chemical synthesis Galantamine - chemistry Galantamine - pharmacology General aspects Glutathione - metabolism Gram-negative bacteria Gram-positive bacteria Lipid Peroxidation - drug effects Magnetic Resonance Spectroscopy Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Phosphorylated derivatives of galanthamine Phosphorylation Rats Rats, Wistar Superoxide Dismutase - metabolism
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