Effect of the Neuraminidase Mutation H274Y Conferring Resistance to Oseltamivir on the Replicative Capacity and Virulence of Old and Recent Human Influenza A(H1N1) Viruses

Background. The viral fitness of neuraminidase inhibitor (NAI)-resistant influenza viruses is believed to be impaired. Unexpectedly, an oseltamivir-resistant A(H1N1) variant containing the H274Y neuraminidase (NA) mutation recently disseminated worldwide, suggesting that the replication and virulenc...

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Veröffentlicht in:	The Journal of infectious diseases 2010-03, Vol.201 (5), p.740-745
Hauptverfasser:	Baz, Mariana, Abed, Yacine, Simon, Philippe, Hamelin, Marie-Ève, Boivin, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution - genetics Animals Antiviral Agents - pharmacology Antivirals Biological and medical sciences Drug Resistance, Viral Ferrets Fundamental and applied biological sciences. Psychology Genetic mutation Humans Infections Infectious diseases Influenza A virus Influenza A Virus, H1N1 Subtype - drug effects Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - pathogenicity Inoculation Medical sciences Microbiology Miscellaneous Mustela Mutation, Missense Nasal Cavity - virology Neuraminidase - genetics Orthomyxoviridae Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - virology Oseltamivir - pharmacology Plaque assay Standard error Viral Plaque Assay Virology Virulence Virus Replication Viruses
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