The effect of nasal oxytocin on pregnancy rates following intrauterine insemination: double-blind, randomized, clinical pilot study
Purpose We tested the hypothesis that the application of intranasal oxytocin (8 IU) following intrauterine insemination (IUI) would increase pregnancy rates, without causing major side effects. Methods Randomized, double-blind, placebo-controlled pilot study: eighty-six couples with idiopathic infer...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2010-04, Vol.281 (4), p.753-759 |
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| creator | Ochsenkühn, Robert Pavlik, Roman Hecht, Stephanie von Schönfeldt, Viktoria Rogenhofer, Nina Thaler, Christian J. |
| description | Purpose
We tested the hypothesis that the application of intranasal oxytocin (8 IU) following intrauterine insemination (IUI) would increase pregnancy rates, without causing major side effects.
Methods
Randomized, double-blind, placebo-controlled pilot study: eighty-six couples with idiopathic infertility, polycystic ovary syndrome and/or male sub-fertility treated with 132 homologous IUI cycles with nasal application of placebo or 8 IU oxytocin following IUI.
Results
In 132 IUI cycles of 86 women, 17 pregnancies were achieved, accounting for a pregnancy rate of 12.9% (17/132) per IUI cycle. The pregnancy rates were 13.4% (9/67) per IUI cycle in the placebo group, and 12.3% (8/65) per IUI cycle in the oxytocin group, the difference not being statistically significant. No relevant side effects were observed in both groups.
Conclusions
Intranasal application of 8 IU oxytocin has no major side effects but at the same time did not affect pregnancy rates after IUI in our population. This study does not exclude that a larger patient group, a different time interval between oxytocin application and IUI, higher or multiple oxytocin applications or a different mode of application would have achieved different effects on pregnancy rates. |
| doi_str_mv | 10.1007/s00404-009-1284-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733925799</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2261885161</sourcerecordid><originalsourceid>FETCH-LOGICAL-c371t-fdf83574592a395a7764490a94ed833c877d78804d377ce5f372e98c9a3256983</originalsourceid><addsrcrecordid>eNp1kU2LFDEQhoMo7uzqD_AiAQ9ebM1XdxJvsvgFC17Wc8gk1WOWdDImadbx6h83wwwsCJ5SqTz1VuBB6AUlbykh8l0lRBAxEKIHypQY9CO0oYKzgUhKH6MN0ceaTPICXdZ6R0in1PQUXVCtGWWcbNCf2x-AYZ7BNZxnnGy1Eedfh5ZdSDgnvC-wSza5Ay62QcVzjjHfh7TDIbVi1wYlJOiXCktItoWc3mOf122EYRtD8m_6YPJ5Cb-h1663gus79iHmhmtb_eEZejLbWOH5-bxC3z99vL3-Mtx8-_z1-sPN4LikbZj9rPgoxaiZ5Xq0Uk5CaGK1AK84d0pKL5UiwnMpHYwzlwy0ctpyNk5a8Sv0-pS7L_nnCrWZJVQHMdoEea1Gcq7ZKLXu5Kt_yLu8ltQ_ZxibqFIjnWin6IlyJddaYDb7EhZbDoYScxRkToJMF2SOgswx-eU5ed0u4B8mzkY6wE5A7U9pB-Vh9f9T_wK4rZwQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261885161</pqid></control><display><type>article</type><title>The effect of nasal oxytocin on pregnancy rates following intrauterine insemination: double-blind, randomized, clinical pilot study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Ochsenkühn, Robert ; Pavlik, Roman ; Hecht, Stephanie ; von Schönfeldt, Viktoria ; Rogenhofer, Nina ; Thaler, Christian J.</creator><creatorcontrib>Ochsenkühn, Robert ; Pavlik, Roman ; Hecht, Stephanie ; von Schönfeldt, Viktoria ; Rogenhofer, Nina ; Thaler, Christian J.</creatorcontrib><description>Purpose
We tested the hypothesis that the application of intranasal oxytocin (8 IU) following intrauterine insemination (IUI) would increase pregnancy rates, without causing major side effects.
Methods
Randomized, double-blind, placebo-controlled pilot study: eighty-six couples with idiopathic infertility, polycystic ovary syndrome and/or male sub-fertility treated with 132 homologous IUI cycles with nasal application of placebo or 8 IU oxytocin following IUI.
Results
In 132 IUI cycles of 86 women, 17 pregnancies were achieved, accounting for a pregnancy rate of 12.9% (17/132) per IUI cycle. The pregnancy rates were 13.4% (9/67) per IUI cycle in the placebo group, and 12.3% (8/65) per IUI cycle in the oxytocin group, the difference not being statistically significant. No relevant side effects were observed in both groups.
Conclusions
Intranasal application of 8 IU oxytocin has no major side effects but at the same time did not affect pregnancy rates after IUI in our population. This study does not exclude that a larger patient group, a different time interval between oxytocin application and IUI, higher or multiple oxytocin applications or a different mode of application would have achieved different effects on pregnancy rates.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-009-1284-9</identifier><identifier>PMID: 19921230</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Administration, Intranasal ; Adolescent ; Adult ; Artificial insemination ; Double-Blind Method ; Double-blind studies ; Endocrinology ; Female ; Fertilization in Vitro ; Gynecology ; Human Genetics ; Humans ; Infertility ; Infertility, Female - therapy ; Insemination, Artificial, Homologous - methods ; Logistic Models ; Male ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Oxytocics - administration & dosage ; Oxytocics - adverse effects ; Oxytocin - administration & dosage ; Oxytocin - adverse effects ; Pilot Projects ; Pregnancy ; Pregnancy Outcome ; Pregnancy Rate ; Reproductive Medicine ; Young Adult</subject><ispartof>Archives of gynecology and obstetrics, 2010-04, Vol.281 (4), p.753-759</ispartof><rights>Springer-Verlag 2009</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2009). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-fdf83574592a395a7764490a94ed833c877d78804d377ce5f372e98c9a3256983</citedby><cites>FETCH-LOGICAL-c371t-fdf83574592a395a7764490a94ed833c877d78804d377ce5f372e98c9a3256983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-009-1284-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-009-1284-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19921230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ochsenkühn, Robert</creatorcontrib><creatorcontrib>Pavlik, Roman</creatorcontrib><creatorcontrib>Hecht, Stephanie</creatorcontrib><creatorcontrib>von Schönfeldt, Viktoria</creatorcontrib><creatorcontrib>Rogenhofer, Nina</creatorcontrib><creatorcontrib>Thaler, Christian J.</creatorcontrib><title>The effect of nasal oxytocin on pregnancy rates following intrauterine insemination: double-blind, randomized, clinical pilot study</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Purpose
We tested the hypothesis that the application of intranasal oxytocin (8 IU) following intrauterine insemination (IUI) would increase pregnancy rates, without causing major side effects.
Methods
Randomized, double-blind, placebo-controlled pilot study: eighty-six couples with idiopathic infertility, polycystic ovary syndrome and/or male sub-fertility treated with 132 homologous IUI cycles with nasal application of placebo or 8 IU oxytocin following IUI.
Results
In 132 IUI cycles of 86 women, 17 pregnancies were achieved, accounting for a pregnancy rate of 12.9% (17/132) per IUI cycle. The pregnancy rates were 13.4% (9/67) per IUI cycle in the placebo group, and 12.3% (8/65) per IUI cycle in the oxytocin group, the difference not being statistically significant. No relevant side effects were observed in both groups.
Conclusions
Intranasal application of 8 IU oxytocin has no major side effects but at the same time did not affect pregnancy rates after IUI in our population. This study does not exclude that a larger patient group, a different time interval between oxytocin application and IUI, higher or multiple oxytocin applications or a different mode of application would have achieved different effects on pregnancy rates.</description><subject>Administration, Intranasal</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Artificial insemination</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Infertility</subject><subject>Infertility, Female - therapy</subject><subject>Insemination, Artificial, Homologous - methods</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Oxytocics - administration & dosage</subject><subject>Oxytocics - adverse effects</subject><subject>Oxytocin - administration & dosage</subject><subject>Oxytocin - adverse effects</subject><subject>Pilot Projects</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy Rate</subject><subject>Reproductive Medicine</subject><subject>Young Adult</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU2LFDEQhoMo7uzqD_AiAQ9ebM1XdxJvsvgFC17Wc8gk1WOWdDImadbx6h83wwwsCJ5SqTz1VuBB6AUlbykh8l0lRBAxEKIHypQY9CO0oYKzgUhKH6MN0ceaTPICXdZ6R0in1PQUXVCtGWWcbNCf2x-AYZ7BNZxnnGy1Eedfh5ZdSDgnvC-wSza5Ay62QcVzjjHfh7TDIbVi1wYlJOiXCktItoWc3mOf122EYRtD8m_6YPJ5Cb-h1663gus79iHmhmtb_eEZejLbWOH5-bxC3z99vL3-Mtx8-_z1-sPN4LikbZj9rPgoxaiZ5Xq0Uk5CaGK1AK84d0pKL5UiwnMpHYwzlwy0ctpyNk5a8Sv0-pS7L_nnCrWZJVQHMdoEea1Gcq7ZKLXu5Kt_yLu8ltQ_ZxibqFIjnWin6IlyJddaYDb7EhZbDoYScxRkToJMF2SOgswx-eU5ed0u4B8mzkY6wE5A7U9pB-Vh9f9T_wK4rZwQ</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Ochsenkühn, Robert</creator><creator>Pavlik, Roman</creator><creator>Hecht, Stephanie</creator><creator>von Schönfeldt, Viktoria</creator><creator>Rogenhofer, Nina</creator><creator>Thaler, Christian J.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20100401</creationdate><title>The effect of nasal oxytocin on pregnancy rates following intrauterine insemination: double-blind, randomized, clinical pilot study</title><author>Ochsenkühn, Robert ; Pavlik, Roman ; Hecht, Stephanie ; von Schönfeldt, Viktoria ; Rogenhofer, Nina ; Thaler, Christian J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-fdf83574592a395a7764490a94ed833c877d78804d377ce5f372e98c9a3256983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Administration, Intranasal</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Artificial insemination</topic><topic>Double-Blind Method</topic><topic>Double-blind studies</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Infertility</topic><topic>Infertility, Female - therapy</topic><topic>Insemination, Artificial, Homologous - methods</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Oxytocics - administration & dosage</topic><topic>Oxytocics - adverse effects</topic><topic>Oxytocin - administration & dosage</topic><topic>Oxytocin - adverse effects</topic><topic>Pilot Projects</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy Rate</topic><topic>Reproductive Medicine</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ochsenkühn, Robert</creatorcontrib><creatorcontrib>Pavlik, Roman</creatorcontrib><creatorcontrib>Hecht, Stephanie</creatorcontrib><creatorcontrib>von Schönfeldt, Viktoria</creatorcontrib><creatorcontrib>Rogenhofer, Nina</creatorcontrib><creatorcontrib>Thaler, Christian J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ochsenkühn, Robert</au><au>Pavlik, Roman</au><au>Hecht, Stephanie</au><au>von Schönfeldt, Viktoria</au><au>Rogenhofer, Nina</au><au>Thaler, Christian J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of nasal oxytocin on pregnancy rates following intrauterine insemination: double-blind, randomized, clinical pilot study</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>281</volume><issue>4</issue><spage>753</spage><epage>759</epage><pages>753-759</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Purpose
We tested the hypothesis that the application of intranasal oxytocin (8 IU) following intrauterine insemination (IUI) would increase pregnancy rates, without causing major side effects.
Methods
Randomized, double-blind, placebo-controlled pilot study: eighty-six couples with idiopathic infertility, polycystic ovary syndrome and/or male sub-fertility treated with 132 homologous IUI cycles with nasal application of placebo or 8 IU oxytocin following IUI.
Results
In 132 IUI cycles of 86 women, 17 pregnancies were achieved, accounting for a pregnancy rate of 12.9% (17/132) per IUI cycle. The pregnancy rates were 13.4% (9/67) per IUI cycle in the placebo group, and 12.3% (8/65) per IUI cycle in the oxytocin group, the difference not being statistically significant. No relevant side effects were observed in both groups.
Conclusions
Intranasal application of 8 IU oxytocin has no major side effects but at the same time did not affect pregnancy rates after IUI in our population. This study does not exclude that a larger patient group, a different time interval between oxytocin application and IUI, higher or multiple oxytocin applications or a different mode of application would have achieved different effects on pregnancy rates.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19921230</pmid><doi>10.1007/s00404-009-1284-9</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0932-0067 |
| ispartof | Archives of gynecology and obstetrics, 2010-04, Vol.281 (4), p.753-759 |
| issn | 0932-0067 1432-0711 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Administration, Intranasal Adolescent Adult Artificial insemination Double-Blind Method Double-blind studies Endocrinology Female Fertilization in Vitro Gynecology Human Genetics Humans Infertility Infertility, Female - therapy Insemination, Artificial, Homologous - methods Logistic Models Male Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Oxytocics - administration & dosage Oxytocics - adverse effects Oxytocin - administration & dosage Oxytocin - adverse effects Pilot Projects Pregnancy Pregnancy Outcome Pregnancy Rate Reproductive Medicine Young Adult |
| title | The effect of nasal oxytocin on pregnancy rates following intrauterine insemination: double-blind, randomized, clinical pilot study |
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