Vascular Endothelial Growth Factor Polymorphisms: Role in Response and Toxicity of Tyrosine Kinase Inhibitors

Angiogenesis is central to the growth of normal tissues and tumors. Inhibiting this pathway has been a strategy for drug development for tumors not responsive to most agents used in chemotherapy. Notably, signaling mediated by vascular endothelial growth factor (VEGF) is a key target because aberran...

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Veröffentlicht in:	Current oncology reports 2010-03, Vol.12 (2), p.102-108
Hauptverfasser:	Vaziri, Susan A. J., Kim, Jenny, Ganapathi, Mahrukh K., Ganapathi, Ram
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans Hypertension - drug therapy Medicine Medicine & Public Health Neoplasms - drug therapy Oncology Polymorphism, Genetic - genetics Protein Kinase Inhibitors - therapeutic use Protein-Tyrosine Kinases - antagonists & inhibitors Vascular Endothelial Growth Factors - genetics
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