VDR gene variants associate with cognitive function and depressive symptoms in old age
Abstract Vitamin D has been recently implicated in brain function. Our objective was to test whether genetic variance in the vitamin D receptor (VDR) gene is associated with cognitive functioning and depressive symptoms in old age. The study was carried out in the prospective population-based Leiden...
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| Veröffentlicht in: | Neurobiology of aging 2009-03, Vol.30 (3), p.466-473 |
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| creator | Kuningas, Maris Mooijaart, Simon P Jolles, Jelle Slagboom, P. Eline Westendorp, Rudi G.J van Heemst, Diana |
| description | Abstract Vitamin D has been recently implicated in brain function. Our objective was to test whether genetic variance in the vitamin D receptor (VDR) gene is associated with cognitive functioning and depressive symptoms in old age. The study was carried out in the prospective population-based Leiden 85-plus Study. All 563 participants of the study were genotyped for Cdx-2 , FokI , BsmI , ApaI and TaqI polymorphisms in the VDR gene. Our data revealed an overall worse performance on tests measuring cognitive functioning for carriers of BsmI ( p = 0.013) and TaqI ( p = 0.004) polymorphisms, and of haplotype 2 (BAt) ( p = 0.004). In contrast, carriers of ApaI variant-allele and of haplotype 1 (baT) had better cognitive functioning together with less depressive symptoms. These associations could not be explained by differences in calcium levels, and by selective survival, since no associations between the VDR gene variants and calcium levels and mortality were observed. In conclusion, our results show that genetic variance in the VDR gene influences the susceptibility to age-related changes in cognitive functioning and in depressive symptoms. |
| doi_str_mv | 10.1016/j.neurobiolaging.2007.07.001 |
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Eline ; Westendorp, Rudi G.J ; van Heemst, Diana</creator><creatorcontrib>Kuningas, Maris ; Mooijaart, Simon P ; Jolles, Jelle ; Slagboom, P. Eline ; Westendorp, Rudi G.J ; van Heemst, Diana</creatorcontrib><description>Abstract Vitamin D has been recently implicated in brain function. Our objective was to test whether genetic variance in the vitamin D receptor (VDR) gene is associated with cognitive functioning and depressive symptoms in old age. The study was carried out in the prospective population-based Leiden 85-plus Study. All 563 participants of the study were genotyped for Cdx-2 , FokI , BsmI , ApaI and TaqI polymorphisms in the VDR gene. Our data revealed an overall worse performance on tests measuring cognitive functioning for carriers of BsmI ( p = 0.013) and TaqI ( p = 0.004) polymorphisms, and of haplotype 2 (BAt) ( p = 0.004). In contrast, carriers of ApaI variant-allele and of haplotype 1 (baT) had better cognitive functioning together with less depressive symptoms. These associations could not be explained by differences in calcium levels, and by selective survival, since no associations between the VDR gene variants and calcium levels and mortality were observed. In conclusion, our results show that genetic variance in the VDR gene influences the susceptibility to age-related changes in cognitive functioning and in depressive symptoms.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2007.07.001</identifier><identifier>PMID: 17714831</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Age Factors ; Aged, 80 and over ; Biological and medical sciences ; Cognition - physiology ; Cognitive functioning ; Cohort Studies ; Depression - diagnosis ; Depression - genetics ; Depression - psychology ; Depressive symptoms ; Development. Senescence. Regeneration. Transplantation ; Female ; Follow-Up Studies ; Fractures ; Fundamental and applied biological sciences. 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Eline</creatorcontrib><creatorcontrib>Westendorp, Rudi G.J</creatorcontrib><creatorcontrib>van Heemst, Diana</creatorcontrib><title>VDR gene variants associate with cognitive function and depressive symptoms in old age</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Abstract Vitamin D has been recently implicated in brain function. Our objective was to test whether genetic variance in the vitamin D receptor (VDR) gene is associated with cognitive functioning and depressive symptoms in old age. The study was carried out in the prospective population-based Leiden 85-plus Study. All 563 participants of the study were genotyped for Cdx-2 , FokI , BsmI , ApaI and TaqI polymorphisms in the VDR gene. Our data revealed an overall worse performance on tests measuring cognitive functioning for carriers of BsmI ( p = 0.013) and TaqI ( p = 0.004) polymorphisms, and of haplotype 2 (BAt) ( p = 0.004). In contrast, carriers of ApaI variant-allele and of haplotype 1 (baT) had better cognitive functioning together with less depressive symptoms. These associations could not be explained by differences in calcium levels, and by selective survival, since no associations between the VDR gene variants and calcium levels and mortality were observed. In conclusion, our results show that genetic variance in the VDR gene influences the susceptibility to age-related changes in cognitive functioning and in depressive symptoms.</description><subject>Age Factors</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cognition - physiology</subject><subject>Cognitive functioning</subject><subject>Cohort Studies</subject><subject>Depression - diagnosis</subject><subject>Depression - genetics</subject><subject>Depression - psychology</subject><subject>Depressive symptoms</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fractures</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Variation - genetics</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Haplotypes - genetics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Mortality</subject><subject>Neurology</subject><subject>Polymorphisms</subject><subject>Prospective Studies</subject><subject>Receptors, Calcitriol - genetics</subject><subject>Risk Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Vitamin D receptor</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkm2L1DAQx4so3t7pV5C8UO9V15mmDwmIIKenwoHgw70NaTKtWbvJXtKu7Le3ZRdFX4gwMDD85vE_WfYUYY2A9YvN2tMUQ-vCoHvn-3UB0KwXA7yXrbCqRI6lbO5nK0DZ5GUl4Cw7T2kDM1g29cPsDJsGS8Fxld3evvnEevLE9jo67cfEdErBOD0S--HGb8yE3rvR7Yl1kzejC55pb5mlXaSUlng6bHdj2CbmPAuDZbqnR9mDTg-JHp_8Rfb1-u2Xq_f5zcd3H65e3-SmAhxzoTWvOJLAFk0Jdl7FNEUhQVdtTVzUwFtpOwJpRFESGSuEROhs3YlWoOYX2eWx7i6Gu4nSqLYuGRoG7SlMSTWcS5R12czk83-SBXDJC1zAl0fQxJBSpE7totvqeFAIalFAbdSfCqhFAbUY4Jz-5NRnardkfyefTj4Dz06ATkYPXdTeuPSLK7gsykrWM3d95Gi-395RVMk48oasi2RGZYP734le_VXIDM67ufd3OlDahCn6WSOFKhUK1Ofla5angQagqITgPwG8RsI1</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Kuningas, Maris</creator><creator>Mooijaart, Simon P</creator><creator>Jolles, Jelle</creator><creator>Slagboom, P. 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Eline ; Westendorp, Rudi G.J ; van Heemst, Diana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-8aa3531e81b1c40d200c72290a5b6e38603b9dfe09c824eecd88910fd6f8b81a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Age Factors</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Cognition - physiology</topic><topic>Cognitive functioning</topic><topic>Cohort Studies</topic><topic>Depression - diagnosis</topic><topic>Depression - genetics</topic><topic>Depression - psychology</topic><topic>Depressive symptoms</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fractures</topic><topic>Fundamental and applied biological sciences. 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Our data revealed an overall worse performance on tests measuring cognitive functioning for carriers of BsmI ( p = 0.013) and TaqI ( p = 0.004) polymorphisms, and of haplotype 2 (BAt) ( p = 0.004). In contrast, carriers of ApaI variant-allele and of haplotype 1 (baT) had better cognitive functioning together with less depressive symptoms. These associations could not be explained by differences in calcium levels, and by selective survival, since no associations between the VDR gene variants and calcium levels and mortality were observed. In conclusion, our results show that genetic variance in the VDR gene influences the susceptibility to age-related changes in cognitive functioning and in depressive symptoms.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>17714831</pmid><doi>10.1016/j.neurobiolaging.2007.07.001</doi><tpages>8</tpages></addata></record> |
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| subjects | Age Factors Aged, 80 and over Biological and medical sciences Cognition - physiology Cognitive functioning Cohort Studies Depression - diagnosis Depression - genetics Depression - psychology Depressive symptoms Development. Senescence. Regeneration. Transplantation Female Follow-Up Studies Fractures Fundamental and applied biological sciences. Psychology Genetic Variation - genetics Genotype Haplotypes Haplotypes - genetics Humans Internal Medicine Male Mortality Neurology Polymorphisms Prospective Studies Receptors, Calcitriol - genetics Risk Factors Vertebrates: nervous system and sense organs Vitamin D receptor |
| title | VDR gene variants associate with cognitive function and depressive symptoms in old age |
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