Bone density and fragility fractures in patients with developmental disabilities
Summary We investigated prior fractures, osteoporosis risk factors, and bone mineral density (BMD) in 107 institutionalized adults with developmental disabilities. We found a very high prevalence of BMD in the osteoporotic range and a significant correlation between lower BMD and prior fragility fra...
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| Veröffentlicht in: | Osteoporosis international 2009-03, Vol.20 (3), p.379-383 |
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| description | Summary We investigated prior fractures, osteoporosis risk factors, and bone mineral density (BMD) in 107 institutionalized adults with developmental disabilities. We found a very high prevalence of BMD in the osteoporotic range and a significant correlation between lower BMD and prior fragility fractures. Introduction The purpose of this study was to investigate factors contributing to osteoporosis and fragility fractures among developmentally disabled adults. Methods Adults from a residential center participated in a prospective study in which bone mineral density (BMD) at the forearm and heel were measured with a portable X-ray densitometer. Prior fragility fractures were identified from chart review. Results Among 107 participants, 84 (78.5%) had a measurement within the osteoporotic range. The heel was more severely abnormal (mean T-score -3.1 ± 1.5) than the forearm (-1.6 ± 1.3, p < .0.0001). Radiographically confirmed prior fragility fractures (17 [16.3%]) were associated with lower heel (p = 0.0155) and forearm (p = 0.0172) T-scores. In multiple regression analysis, there were independent associations between forearm BMD and prior fragility fractures (p = 0.0126) and between heel BMD and prior fragility fractures (p = 0.0291). The odds ratio for prior fracture increased by 2.02 (95% CI 1.12-3.64) for each standard deviation (SD) decrease in heel T-score and by 2.39 (95% CI 1.08-5.32) for each SD decrease in forearm T-score. Conclusions We found a very high prevalence of osteoporotic BMD measurements in institutionalized adults with developmental disabilities. Lower heel and forearm BMD measurements were significantly and independently associated with prior fragility fractures in this population. |
| doi_str_mv | 10.1007/s00198-008-0678-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733919002</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20415829</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-fc3ca017ffabe6a12e09f85314aed29e25a50b9e2322e611a53ee5d71564c7223</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhi0EokvhB3CBCAk4BWbsOImPUPElVQIJKnGzZp3J4irrbO0E1P56HGVFJQ49WOOxn3c89mshniK8QYDmbQJA05YAedRNW97cExuslCqlqfV9sQGjmtJU-PNEPErpErLGmOahOMG2lkbX1UZ8ez8GLjoOyU_XBYWu6CPt_LBkeeamOXIqfCgONHkOUyr--OlXFvzmYTzs8woNRecTbReN5_RYPOhpSPzkGE_FxccPP84-l-dfP305e3deukrrqeydcgTY9D1tuSaUDKZvtcKKuJOGpSYN2xyVlFwjklbMumswd-0aKdWpeL3WPcTxauY02b1PjoeBAo9zso1SBg3AQr66k5RQoW6lyeCL_8DLcY4h38JKbFslG11lCFfIxTGlyL09RL-neG0R7OKKXV2x2RW7uGJvsubZsfC83XN3qzjakIGXR4CSoyE_fHA-_eMkgqlbrDMnVy7lrbDjeNvhXac_X0U9jZZ2MRe--C4BFaDOH0SD-guWz65W</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218832754</pqid></control><display><type>article</type><title>Bone density and fragility fractures in patients with developmental disabilities</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Leslie, W. D ; Pahlavan, P. S ; Roe, E. B ; Dittberner, K</creator><creatorcontrib>Leslie, W. D ; Pahlavan, P. S ; Roe, E. B ; Dittberner, K</creatorcontrib><description>Summary We investigated prior fractures, osteoporosis risk factors, and bone mineral density (BMD) in 107 institutionalized adults with developmental disabilities. We found a very high prevalence of BMD in the osteoporotic range and a significant correlation between lower BMD and prior fragility fractures. Introduction The purpose of this study was to investigate factors contributing to osteoporosis and fragility fractures among developmentally disabled adults. Methods Adults from a residential center participated in a prospective study in which bone mineral density (BMD) at the forearm and heel were measured with a portable X-ray densitometer. Prior fragility fractures were identified from chart review. Results Among 107 participants, 84 (78.5%) had a measurement within the osteoporotic range. The heel was more severely abnormal (mean T-score -3.1 ± 1.5) than the forearm (-1.6 ± 1.3, p < .0.0001). Radiographically confirmed prior fragility fractures (17 [16.3%]) were associated with lower heel (p = 0.0155) and forearm (p = 0.0172) T-scores. In multiple regression analysis, there were independent associations between forearm BMD and prior fragility fractures (p = 0.0126) and between heel BMD and prior fragility fractures (p = 0.0291). The odds ratio for prior fracture increased by 2.02 (95% CI 1.12-3.64) for each standard deviation (SD) decrease in heel T-score and by 2.39 (95% CI 1.08-5.32) for each SD decrease in forearm T-score. Conclusions We found a very high prevalence of osteoporotic BMD measurements in institutionalized adults with developmental disabilities. Lower heel and forearm BMD measurements were significantly and independently associated with prior fragility fractures in this population.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-008-0678-z</identifier><identifier>PMID: 18629564</identifier><language>eng</language><publisher>London: London : Springer-Verlag</publisher><subject>Absorptiometry, Photon ; Adolescent ; Adult ; Adults ; Biological and medical sciences ; Bone density ; Bone Density - physiology ; Calcaneus - diagnostic imaging ; Developmental disabilities ; Developmental Disabilities - complications ; Developmental disability ; Diseases of the osteoarticular system ; Endocrinology ; Female ; Fracture ; Fractures ; Fractures, Bone - complications ; Humans ; Injuries of the limb. Injuries of the spine ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Manitoba ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Orthopedics ; Osteoarticular system. Muscles ; Osteoporosis ; Osteoporosis - complications ; Osteoporosis. Osteomalacia. Paget disease ; Peripheral DXA ; Prospective Studies ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Radius - diagnostic imaging ; Rheumatology ; Risk Factors ; Traumas. Diseases due to physical agents ; Young Adult</subject><ispartof>Osteoporosis international, 2009-03, Vol.20 (3), p.379-383</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2008</rights><rights>2009 INIST-CNRS</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-fc3ca017ffabe6a12e09f85314aed29e25a50b9e2322e611a53ee5d71564c7223</citedby><cites>FETCH-LOGICAL-c455t-fc3ca017ffabe6a12e09f85314aed29e25a50b9e2322e611a53ee5d71564c7223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-008-0678-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-008-0678-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21096816$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18629564$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leslie, W. D</creatorcontrib><creatorcontrib>Pahlavan, P. S</creatorcontrib><creatorcontrib>Roe, E. B</creatorcontrib><creatorcontrib>Dittberner, K</creatorcontrib><title>Bone density and fragility fractures in patients with developmental disabilities</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary We investigated prior fractures, osteoporosis risk factors, and bone mineral density (BMD) in 107 institutionalized adults with developmental disabilities. We found a very high prevalence of BMD in the osteoporotic range and a significant correlation between lower BMD and prior fragility fractures. Introduction The purpose of this study was to investigate factors contributing to osteoporosis and fragility fractures among developmentally disabled adults. Methods Adults from a residential center participated in a prospective study in which bone mineral density (BMD) at the forearm and heel were measured with a portable X-ray densitometer. Prior fragility fractures were identified from chart review. Results Among 107 participants, 84 (78.5%) had a measurement within the osteoporotic range. The heel was more severely abnormal (mean T-score -3.1 ± 1.5) than the forearm (-1.6 ± 1.3, p < .0.0001). Radiographically confirmed prior fragility fractures (17 [16.3%]) were associated with lower heel (p = 0.0155) and forearm (p = 0.0172) T-scores. In multiple regression analysis, there were independent associations between forearm BMD and prior fragility fractures (p = 0.0126) and between heel BMD and prior fragility fractures (p = 0.0291). The odds ratio for prior fracture increased by 2.02 (95% CI 1.12-3.64) for each standard deviation (SD) decrease in heel T-score and by 2.39 (95% CI 1.08-5.32) for each SD decrease in forearm T-score. Conclusions We found a very high prevalence of osteoporotic BMD measurements in institutionalized adults with developmental disabilities. Lower heel and forearm BMD measurements were significantly and independently associated with prior fragility fractures in this population.</description><subject>Absorptiometry, Photon</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Biological and medical sciences</subject><subject>Bone density</subject><subject>Bone Density - physiology</subject><subject>Calcaneus - diagnostic imaging</subject><subject>Developmental disabilities</subject><subject>Developmental Disabilities - complications</subject><subject>Developmental disability</subject><subject>Diseases of the osteoarticular system</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fracture</subject><subject>Fractures</subject><subject>Fractures, Bone - complications</subject><subject>Humans</subject><subject>Injuries of the limb. Injuries of the spine</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Manitoba</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoarticular system. Muscles</subject><subject>Osteoporosis</subject><subject>Osteoporosis - complications</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Peripheral DXA</subject><subject>Prospective Studies</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Radius - diagnostic imaging</subject><subject>Rheumatology</subject><subject>Risk Factors</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Young Adult</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kk1v1DAQhi0EokvhB3CBCAk4BWbsOImPUPElVQIJKnGzZp3J4irrbO0E1P56HGVFJQ49WOOxn3c89mshniK8QYDmbQJA05YAedRNW97cExuslCqlqfV9sQGjmtJU-PNEPErpErLGmOahOMG2lkbX1UZ8ez8GLjoOyU_XBYWu6CPt_LBkeeamOXIqfCgONHkOUyr--OlXFvzmYTzs8woNRecTbReN5_RYPOhpSPzkGE_FxccPP84-l-dfP305e3deukrrqeydcgTY9D1tuSaUDKZvtcKKuJOGpSYN2xyVlFwjklbMumswd-0aKdWpeL3WPcTxauY02b1PjoeBAo9zso1SBg3AQr66k5RQoW6lyeCL_8DLcY4h38JKbFslG11lCFfIxTGlyL09RL-neG0R7OKKXV2x2RW7uGJvsubZsfC83XN3qzjakIGXR4CSoyE_fHA-_eMkgqlbrDMnVy7lrbDjeNvhXac_X0U9jZZ2MRe--C4BFaDOH0SD-guWz65W</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Leslie, W. D</creator><creator>Pahlavan, P. S</creator><creator>Roe, E. B</creator><creator>Dittberner, K</creator><general>London : Springer-Verlag</general><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>Bone density and fragility fractures in patients with developmental disabilities</title><author>Leslie, W. D ; Pahlavan, P. S ; Roe, E. B ; Dittberner, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-fc3ca017ffabe6a12e09f85314aed29e25a50b9e2322e611a53ee5d71564c7223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Absorptiometry, Photon</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Adults</topic><topic>Biological and medical sciences</topic><topic>Bone density</topic><topic>Bone Density - physiology</topic><topic>Calcaneus - diagnostic imaging</topic><topic>Developmental disabilities</topic><topic>Developmental Disabilities - complications</topic><topic>Developmental disability</topic><topic>Diseases of the osteoarticular system</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Fracture</topic><topic>Fractures</topic><topic>Fractures, Bone - complications</topic><topic>Humans</topic><topic>Injuries of the limb. Injuries of the spine</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Manitoba</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteoarticular system. Muscles</topic><topic>Osteoporosis</topic><topic>Osteoporosis - complications</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Peripheral DXA</topic><topic>Prospective Studies</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Radius - diagnostic imaging</topic><topic>Rheumatology</topic><topic>Risk Factors</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leslie, W. D</creatorcontrib><creatorcontrib>Pahlavan, P. S</creatorcontrib><creatorcontrib>Roe, E. 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D</au><au>Pahlavan, P. S</au><au>Roe, E. B</au><au>Dittberner, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone density and fragility fractures in patients with developmental disabilities</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>20</volume><issue>3</issue><spage>379</spage><epage>383</epage><pages>379-383</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary We investigated prior fractures, osteoporosis risk factors, and bone mineral density (BMD) in 107 institutionalized adults with developmental disabilities. We found a very high prevalence of BMD in the osteoporotic range and a significant correlation between lower BMD and prior fragility fractures. Introduction The purpose of this study was to investigate factors contributing to osteoporosis and fragility fractures among developmentally disabled adults. Methods Adults from a residential center participated in a prospective study in which bone mineral density (BMD) at the forearm and heel were measured with a portable X-ray densitometer. Prior fragility fractures were identified from chart review. Results Among 107 participants, 84 (78.5%) had a measurement within the osteoporotic range. The heel was more severely abnormal (mean T-score -3.1 ± 1.5) than the forearm (-1.6 ± 1.3, p < .0.0001). Radiographically confirmed prior fragility fractures (17 [16.3%]) were associated with lower heel (p = 0.0155) and forearm (p = 0.0172) T-scores. In multiple regression analysis, there were independent associations between forearm BMD and prior fragility fractures (p = 0.0126) and between heel BMD and prior fragility fractures (p = 0.0291). The odds ratio for prior fracture increased by 2.02 (95% CI 1.12-3.64) for each standard deviation (SD) decrease in heel T-score and by 2.39 (95% CI 1.08-5.32) for each SD decrease in forearm T-score. Conclusions We found a very high prevalence of osteoporotic BMD measurements in institutionalized adults with developmental disabilities. Lower heel and forearm BMD measurements were significantly and independently associated with prior fragility fractures in this population.</abstract><cop>London</cop><pub>London : Springer-Verlag</pub><pmid>18629564</pmid><doi>10.1007/s00198-008-0678-z</doi><tpages>5</tpages></addata></record> |
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| subjects | Absorptiometry, Photon Adolescent Adult Adults Biological and medical sciences Bone density Bone Density - physiology Calcaneus - diagnostic imaging Developmental disabilities Developmental Disabilities - complications Developmental disability Diseases of the osteoarticular system Endocrinology Female Fracture Fractures Fractures, Bone - complications Humans Injuries of the limb. Injuries of the spine Investigative techniques, diagnostic techniques (general aspects) Male Manitoba Medical sciences Medicine Medicine & Public Health Middle Aged Original Article Orthopedics Osteoarticular system. Muscles Osteoporosis Osteoporosis - complications Osteoporosis. Osteomalacia. Paget disease Peripheral DXA Prospective Studies Radiodiagnosis. Nmr imagery. Nmr spectrometry Radius - diagnostic imaging Rheumatology Risk Factors Traumas. Diseases due to physical agents Young Adult |
| title | Bone density and fragility fractures in patients with developmental disabilities |
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