Kaposi's sarcoma : a review of gene expression and ultrastructure of KS spindle cells in vivo
The ultrastructural features and the gene expression pattern of Kaposi's sarcoma (KS) spindle cells in vivo suggest that KS is a tumor of the mixed cell type. The expression pattern of cytokines and cytokine receptors in the tumor lesion, together with the results obtained from in vitro charact...
Gespeichert in:
| Veröffentlicht in: | AIDS research and human retroviruses 1992-10, Vol.8 (10), p.1753-1763 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1763 |
|---|---|
| container_issue | 10 |
| container_start_page | 1753 |
| container_title | AIDS research and human retroviruses |
| container_volume | 8 |
| creator | STÜRZL, M BRANDSTETTER, H ROTH, W. K |
| description | The ultrastructural features and the gene expression pattern of Kaposi's sarcoma (KS) spindle cells in vivo suggest that KS is a tumor of the mixed cell type. The expression pattern of cytokines and cytokine receptors in the tumor lesion, together with the results obtained from in vitro characterization of KS-derived cells, provide evidence that paracrine mechanisms of growth factor action are important for the maintenance of KS. The reports on virus infection of KS cells suggest an indirect role of virus infection in the induction of KS, most likely mediated by immunostimulation and subsequent production of cytokines. |
| doi_str_mv | 10.1089/aid.1992.8.1753 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73391838</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73391838</sourcerecordid><originalsourceid>FETCH-LOGICAL-c267t-9424c3db2d648a63e9b7404ef3162288425adb7e269b336ba5f52eb3df68e0833</originalsourceid><addsrcrecordid>eNqFkDtr3EAUhYcQY6-d1KkMUwS70npemke6sPjFGlzYKcMwkq7CBL0yV9rY_94Suzhlqluc7x4OHyFfOFtzZt1ViNWaOyfWds1NLj-QFXeSZ1ax_CNZMWtdJoRwJ-QU8TdjzAmRH5NjrnLDrVuRn9sw9BgvkWJIZd8G-o0GmmAX4S_ta_oLOqDwMiRAjH1HQ1fRqRlTwDFN5TglWKjtE8UhdlUDtISmQRo7uou7_hM5qkOD8Plwz8iPm-vnzV328Hh7v_n-kJVCmzFzSqhSVoWotLJBS3CFUUxBLbkWwlol8lAVBoR2hZS6CHmdCyhkVWsLzEp5Ri72vUPq_0yAo28jLktCB_2E3kjpuJX2vyDXcl5kzAxe7cEy9YgJaj-k2Ib06jnzi3k_m_eLeW_9Yn7-OD9UT0UL1T9-r3rOvx7ygGVo6hS6MuI7ppS2lhn5BmWeizU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16326777</pqid></control><display><type>article</type><title>Kaposi's sarcoma : a review of gene expression and ultrastructure of KS spindle cells in vivo</title><source>Mary Ann Liebert Online Subscription</source><source>MEDLINE</source><creator>STÜRZL, M ; BRANDSTETTER, H ; ROTH, W. K</creator><creatorcontrib>STÜRZL, M ; BRANDSTETTER, H ; ROTH, W. K</creatorcontrib><description>The ultrastructural features and the gene expression pattern of Kaposi's sarcoma (KS) spindle cells in vivo suggest that KS is a tumor of the mixed cell type. The expression pattern of cytokines and cytokine receptors in the tumor lesion, together with the results obtained from in vitro characterization of KS-derived cells, provide evidence that paracrine mechanisms of growth factor action are important for the maintenance of KS. The reports on virus infection of KS cells suggest an indirect role of virus infection in the induction of KS, most likely mediated by immunostimulation and subsequent production of cytokines.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/aid.1992.8.1753</identifier><identifier>PMID: 1457189</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>AIDS/HIV ; Biological and medical sciences ; Biomarkers ; Cytokines - genetics ; Dermatology ; Gene Expression ; Genes, Viral ; human immunodeficiency virus ; Humans ; Medical sciences ; Oncogenes ; Sarcoma, Kaposi - genetics ; Sarcoma, Kaposi - ultrastructure ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>AIDS research and human retroviruses, 1992-10, Vol.8 (10), p.1753-1763</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c267t-9424c3db2d648a63e9b7404ef3162288425adb7e269b336ba5f52eb3df68e0833</citedby><cites>FETCH-LOGICAL-c267t-9424c3db2d648a63e9b7404ef3162288425adb7e269b336ba5f52eb3df68e0833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3029,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4468807$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1457189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STÜRZL, M</creatorcontrib><creatorcontrib>BRANDSTETTER, H</creatorcontrib><creatorcontrib>ROTH, W. K</creatorcontrib><title>Kaposi's sarcoma : a review of gene expression and ultrastructure of KS spindle cells in vivo</title><title>AIDS research and human retroviruses</title><addtitle>AIDS Res Hum Retroviruses</addtitle><description>The ultrastructural features and the gene expression pattern of Kaposi's sarcoma (KS) spindle cells in vivo suggest that KS is a tumor of the mixed cell type. The expression pattern of cytokines and cytokine receptors in the tumor lesion, together with the results obtained from in vitro characterization of KS-derived cells, provide evidence that paracrine mechanisms of growth factor action are important for the maintenance of KS. The reports on virus infection of KS cells suggest an indirect role of virus infection in the induction of KS, most likely mediated by immunostimulation and subsequent production of cytokines.</description><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Cytokines - genetics</subject><subject>Dermatology</subject><subject>Gene Expression</subject><subject>Genes, Viral</subject><subject>human immunodeficiency virus</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Oncogenes</subject><subject>Sarcoma, Kaposi - genetics</subject><subject>Sarcoma, Kaposi - ultrastructure</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtr3EAUhYcQY6-d1KkMUwS70npemke6sPjFGlzYKcMwkq7CBL0yV9rY_94Suzhlqluc7x4OHyFfOFtzZt1ViNWaOyfWds1NLj-QFXeSZ1ax_CNZMWtdJoRwJ-QU8TdjzAmRH5NjrnLDrVuRn9sw9BgvkWJIZd8G-o0GmmAX4S_ta_oLOqDwMiRAjH1HQ1fRqRlTwDFN5TglWKjtE8UhdlUDtISmQRo7uou7_hM5qkOD8Plwz8iPm-vnzV328Hh7v_n-kJVCmzFzSqhSVoWotLJBS3CFUUxBLbkWwlol8lAVBoR2hZS6CHmdCyhkVWsLzEp5Ri72vUPq_0yAo28jLktCB_2E3kjpuJX2vyDXcl5kzAxe7cEy9YgJaj-k2Ib06jnzi3k_m_eLeW_9Yn7-OD9UT0UL1T9-r3rOvx7ygGVo6hS6MuI7ppS2lhn5BmWeizU</recordid><startdate>199210</startdate><enddate>199210</enddate><creator>STÜRZL, M</creator><creator>BRANDSTETTER, H</creator><creator>ROTH, W. K</creator><general>Liebert</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199210</creationdate><title>Kaposi's sarcoma : a review of gene expression and ultrastructure of KS spindle cells in vivo</title><author>STÜRZL, M ; BRANDSTETTER, H ; ROTH, W. K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c267t-9424c3db2d648a63e9b7404ef3162288425adb7e269b336ba5f52eb3df68e0833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Cytokines - genetics</topic><topic>Dermatology</topic><topic>Gene Expression</topic><topic>Genes, Viral</topic><topic>human immunodeficiency virus</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Oncogenes</topic><topic>Sarcoma, Kaposi - genetics</topic><topic>Sarcoma, Kaposi - ultrastructure</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STÜRZL, M</creatorcontrib><creatorcontrib>BRANDSTETTER, H</creatorcontrib><creatorcontrib>ROTH, W. K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS research and human retroviruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STÜRZL, M</au><au>BRANDSTETTER, H</au><au>ROTH, W. K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kaposi's sarcoma : a review of gene expression and ultrastructure of KS spindle cells in vivo</atitle><jtitle>AIDS research and human retroviruses</jtitle><addtitle>AIDS Res Hum Retroviruses</addtitle><date>1992-10</date><risdate>1992</risdate><volume>8</volume><issue>10</issue><spage>1753</spage><epage>1763</epage><pages>1753-1763</pages><issn>0889-2229</issn><eissn>1931-8405</eissn><coden>ARHRE7</coden><abstract>The ultrastructural features and the gene expression pattern of Kaposi's sarcoma (KS) spindle cells in vivo suggest that KS is a tumor of the mixed cell type. The expression pattern of cytokines and cytokine receptors in the tumor lesion, together with the results obtained from in vitro characterization of KS-derived cells, provide evidence that paracrine mechanisms of growth factor action are important for the maintenance of KS. The reports on virus infection of KS cells suggest an indirect role of virus infection in the induction of KS, most likely mediated by immunostimulation and subsequent production of cytokines.</abstract><cop>Larchmont, NY</cop><pub>Liebert</pub><pmid>1457189</pmid><doi>10.1089/aid.1992.8.1753</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0889-2229 |
| ispartof | AIDS research and human retroviruses, 1992-10, Vol.8 (10), p.1753-1763 |
| issn | 0889-2229 1931-8405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73391838 |
| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | AIDS/HIV Biological and medical sciences Biomarkers Cytokines - genetics Dermatology Gene Expression Genes, Viral human immunodeficiency virus Humans Medical sciences Oncogenes Sarcoma, Kaposi - genetics Sarcoma, Kaposi - ultrastructure Tumors of the skin and soft tissue. Premalignant lesions |
| title | Kaposi's sarcoma : a review of gene expression and ultrastructure of KS spindle cells in vivo |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T04%3A54%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Kaposi's%20sarcoma%20:%20a%20review%20of%20gene%20expression%20and%20ultrastructure%20of%20KS%20spindle%20cells%20in%20vivo&rft.jtitle=AIDS%20research%20and%20human%20retroviruses&rft.au=ST%C3%9CRZL,%20M&rft.date=1992-10&rft.volume=8&rft.issue=10&rft.spage=1753&rft.epage=1763&rft.pages=1753-1763&rft.issn=0889-2229&rft.eissn=1931-8405&rft.coden=ARHRE7&rft_id=info:doi/10.1089/aid.1992.8.1753&rft_dat=%3Cproquest_cross%3E73391838%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16326777&rft_id=info:pmid/1457189&rfr_iscdi=true |