Relationship between structure and antibacterial activity of lipophilic N -acyldiamines

Abstract We report in this work the preparation and antibacterial evaluation of a series of N -monoacylated diamines against six Gram-positive and 11 Gram-negative bacteria. The results obtained showed the existence of relationship between lipophilicity and antibacterial activity of the tested compo...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2010-04, Vol.64 (4), p.287-290
Hauptverfasser:	de Almeida, Camila G, Garbois, Gabriela D, Amaral, Lorena M, Diniz, Cláudio C, Le Hyaric, Mireille
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Biological and medical sciences Diamines - administration & dosage Diamines - chemistry Diamines - pharmacology Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Internal Medicine Lipophilicity Medical Education Medical sciences MIC Microbial Sensitivity Tests N-acyl-diamines Pharmacology. Drug treatments Structure-Activity Relationship
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