The burden of influenza in children under 5 years admitted to the Children's Hospital at Westmead in the winter of 2006
Objective: Active surveillance to determine influenza disease burden in children admitted to hospital with influenza‐like illness (ILI). Methods: A prospective hospital‐based cohort study conducted June–October 2006 in children
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| Veröffentlicht in: | Journal of paediatrics and child health 2009-12, Vol.45 (12), p.698-703 |
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| creator | Iskander, Mary Kesson, Alison Dwyer, Dominic Rost, Laura Pym, Margaret Wang, Han McCaskill, Mary Booy, Robert |
| description | Objective: Active surveillance to determine influenza disease burden in children admitted to hospital with influenza‐like illness (ILI).
Methods: A prospective hospital‐based cohort study conducted June–October 2006 in children |
| doi_str_mv | 10.1111/j.1440-1754.2009.01597.x |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733913385</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733913385</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4647-281df162039b879d51f311c2ca8d6c448efbbb4fca85d22d037458158805c9bf3</originalsourceid><addsrcrecordid>eNqNkc1u1DAUhSMEoqXwCshiQVcJvv6Ls2CBRtBpqQBBaZeWE9uqh_xM7USdYVWJN-VJcJhRkVggvPG17nfOvdbJMgS4gHRerQpgDOdQclYQjKsCA6_KYvMgO7xvPEw1pixnEvBB9iTGFcaYcC4fZwdQyYozCofZ9uLaonoKxvZocMj3rp1s_12nCjXXvjUhNabe2ID4z7sfW6tDRNp0fhytQeOAxqRf7MHjiJZDXPtRt0iP6MrGsbPazF4zduv7MfmkMWln8TR75HQb7bP9fZR9fff2YrHMzz-enC7enOcNE6zMiQTjQBBMq1qWleHgKEBDGi2NaBiT1tV1zVx6c0OIwbRkXAKXEvOmqh09yo53vusw3ExpJdX52Ni21b0dpqhKSiugVPJEvvwnSYACKYVI4Iu_wNUwhT79QhEsRUWElAmSO6gJQ4zBOrUOvtNhqwCrOUW1UnNYag5LzSmq3ymqTZI-3_tPdWfNH-E-tgS83gG3vrXb_zZWZ58Wc5X0-U7v42g393odvilR0pKrqw8n6stSnLHLz5fqPf0Fzrm5fw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>208692688</pqid></control><display><type>article</type><title>The burden of influenza in children under 5 years admitted to the Children's Hospital at Westmead in the winter of 2006</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Iskander, Mary ; Kesson, Alison ; Dwyer, Dominic ; Rost, Laura ; Pym, Margaret ; Wang, Han ; McCaskill, Mary ; Booy, Robert</creator><creatorcontrib>Iskander, Mary ; Kesson, Alison ; Dwyer, Dominic ; Rost, Laura ; Pym, Margaret ; Wang, Han ; McCaskill, Mary ; Booy, Robert</creatorcontrib><description>Objective: Active surveillance to determine influenza disease burden in children admitted to hospital with influenza‐like illness (ILI).
Methods: A prospective hospital‐based cohort study conducted June–October 2006 in children <5 years hospitalised at The Children's Hospital at Westmead with ILI (fever and respiratory symptoms). Influenza and other viral infections were diagnosed either by antigen detection using immunofluorescence or nucleic acid amplification testing of nasopharyngeal aspirates. Data were collected using researcher‐administered questionnaires. Main outcome measures include proportion of hospitalisations with influenza, vaccination and treatment, risk factors for influenza and associated medical and social burdens.
Results: Data on 275 children with ILI aged <5 years were analysed. Thirty‐one (11%) children with ILI had influenza (22 had influenza A and 9 had influenza B). Thirty‐five percent were under 6 months of age and 61% under 1 year. Twenty‐nine percent of children with influenza A were born prematurely. The mean duration of hospital stay for influenza was 2.8 days (95% confidence interval 2.1–3.4) and 26% had a lumbar puncture. Although 68% received intravenous antibiotics, only 3% (one case) was given an antiviral. Eighty‐four percent had visited their local doctor before admission and all came through the emergency department. On average, in one‐third (32%) of families of children with influenza a parent developed, ILI during admission or soon after hospital discharge resulted in an average of 3.2 days of work absenteeism. Only 3.5% (7/199) of children older than 6 months with ILI received any influenza vaccination.
Conclusions: Both the burden of influenza in childhood morbidity and its social impact are substantial. There is considerable room for improvement in both the prevention and early recognition (trigger treatment with antivirals) of influenza. Our data will inform decisions regarding the value of a universal influenza vaccine programme.</description><identifier>ISSN: 1034-4810</identifier><identifier>EISSN: 1440-1754</identifier><identifier>DOI: 10.1111/j.1440-1754.2009.01597.x</identifier><identifier>PMID: 19895431</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>child ; Child, Preschool ; Children & youth ; Cohort Studies ; Cost of Illness ; Female ; hospitalizatioin ; Hospitalization ; Hospitals, Pediatric ; Humans ; Immunization ; Infant ; Infant, Newborn ; Influenza ; Influenza A virus - isolation & purification ; Influenza B virus - isolation & purification ; Influenza, Human - diagnosis ; Influenza, Human - drug therapy ; Influenza, Human - epidemiology ; Influenza, Human - immunology ; Influenza, Human - physiopathology ; Inpatients ; Male ; New South Wales - epidemiology ; Population Surveillance ; Prospective Studies ; Social impact</subject><ispartof>Journal of paediatrics and child health, 2009-12, Vol.45 (12), p.698-703</ispartof><rights>2009 The Authors. Journal compilation © 2009 Paediatrics and Child Health Division (Royal Australasian College of Physicians)</rights><rights>Journal compilation © 2009 Paediatrics and Child Health Division (Royal Australasian College of Physicians)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4647-281df162039b879d51f311c2ca8d6c448efbbb4fca85d22d037458158805c9bf3</citedby><cites>FETCH-LOGICAL-c4647-281df162039b879d51f311c2ca8d6c448efbbb4fca85d22d037458158805c9bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1754.2009.01597.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1754.2009.01597.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19895431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iskander, Mary</creatorcontrib><creatorcontrib>Kesson, Alison</creatorcontrib><creatorcontrib>Dwyer, Dominic</creatorcontrib><creatorcontrib>Rost, Laura</creatorcontrib><creatorcontrib>Pym, Margaret</creatorcontrib><creatorcontrib>Wang, Han</creatorcontrib><creatorcontrib>McCaskill, Mary</creatorcontrib><creatorcontrib>Booy, Robert</creatorcontrib><title>The burden of influenza in children under 5 years admitted to the Children's Hospital at Westmead in the winter of 2006</title><title>Journal of paediatrics and child health</title><addtitle>J Paediatr Child Health</addtitle><description>Objective: Active surveillance to determine influenza disease burden in children admitted to hospital with influenza‐like illness (ILI).
Methods: A prospective hospital‐based cohort study conducted June–October 2006 in children <5 years hospitalised at The Children's Hospital at Westmead with ILI (fever and respiratory symptoms). Influenza and other viral infections were diagnosed either by antigen detection using immunofluorescence or nucleic acid amplification testing of nasopharyngeal aspirates. Data were collected using researcher‐administered questionnaires. Main outcome measures include proportion of hospitalisations with influenza, vaccination and treatment, risk factors for influenza and associated medical and social burdens.
Results: Data on 275 children with ILI aged <5 years were analysed. Thirty‐one (11%) children with ILI had influenza (22 had influenza A and 9 had influenza B). Thirty‐five percent were under 6 months of age and 61% under 1 year. Twenty‐nine percent of children with influenza A were born prematurely. The mean duration of hospital stay for influenza was 2.8 days (95% confidence interval 2.1–3.4) and 26% had a lumbar puncture. Although 68% received intravenous antibiotics, only 3% (one case) was given an antiviral. Eighty‐four percent had visited their local doctor before admission and all came through the emergency department. On average, in one‐third (32%) of families of children with influenza a parent developed, ILI during admission or soon after hospital discharge resulted in an average of 3.2 days of work absenteeism. Only 3.5% (7/199) of children older than 6 months with ILI received any influenza vaccination.
Conclusions: Both the burden of influenza in childhood morbidity and its social impact are substantial. There is considerable room for improvement in both the prevention and early recognition (trigger treatment with antivirals) of influenza. Our data will inform decisions regarding the value of a universal influenza vaccine programme.</description><subject>child</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Cohort Studies</subject><subject>Cost of Illness</subject><subject>Female</subject><subject>hospitalizatioin</subject><subject>Hospitalization</subject><subject>Hospitals, Pediatric</subject><subject>Humans</subject><subject>Immunization</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Influenza</subject><subject>Influenza A virus - isolation & purification</subject><subject>Influenza B virus - isolation & purification</subject><subject>Influenza, Human - diagnosis</subject><subject>Influenza, Human - drug therapy</subject><subject>Influenza, Human - epidemiology</subject><subject>Influenza, Human - immunology</subject><subject>Influenza, Human - physiopathology</subject><subject>Inpatients</subject><subject>Male</subject><subject>New South Wales - epidemiology</subject><subject>Population Surveillance</subject><subject>Prospective Studies</subject><subject>Social impact</subject><issn>1034-4810</issn><issn>1440-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhSMEoqXwCshiQVcJvv6Ls2CBRtBpqQBBaZeWE9uqh_xM7USdYVWJN-VJcJhRkVggvPG17nfOvdbJMgS4gHRerQpgDOdQclYQjKsCA6_KYvMgO7xvPEw1pixnEvBB9iTGFcaYcC4fZwdQyYozCofZ9uLaonoKxvZocMj3rp1s_12nCjXXvjUhNabe2ID4z7sfW6tDRNp0fhytQeOAxqRf7MHjiJZDXPtRt0iP6MrGsbPazF4zduv7MfmkMWln8TR75HQb7bP9fZR9fff2YrHMzz-enC7enOcNE6zMiQTjQBBMq1qWleHgKEBDGi2NaBiT1tV1zVx6c0OIwbRkXAKXEvOmqh09yo53vusw3ExpJdX52Ni21b0dpqhKSiugVPJEvvwnSYACKYVI4Iu_wNUwhT79QhEsRUWElAmSO6gJQ4zBOrUOvtNhqwCrOUW1UnNYag5LzSmq3ymqTZI-3_tPdWfNH-E-tgS83gG3vrXb_zZWZ58Wc5X0-U7v42g393odvilR0pKrqw8n6stSnLHLz5fqPf0Fzrm5fw</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Iskander, Mary</creator><creator>Kesson, Alison</creator><creator>Dwyer, Dominic</creator><creator>Rost, Laura</creator><creator>Pym, Margaret</creator><creator>Wang, Han</creator><creator>McCaskill, Mary</creator><creator>Booy, Robert</creator><general>Blackwell Publishing Asia</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U1</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200912</creationdate><title>The burden of influenza in children under 5 years admitted to the Children's Hospital at Westmead in the winter of 2006</title><author>Iskander, Mary ; Kesson, Alison ; Dwyer, Dominic ; Rost, Laura ; Pym, Margaret ; Wang, Han ; McCaskill, Mary ; Booy, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4647-281df162039b879d51f311c2ca8d6c448efbbb4fca85d22d037458158805c9bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>child</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Cohort Studies</topic><topic>Cost of Illness</topic><topic>Female</topic><topic>hospitalizatioin</topic><topic>Hospitalization</topic><topic>Hospitals, Pediatric</topic><topic>Humans</topic><topic>Immunization</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Influenza</topic><topic>Influenza A virus - isolation & purification</topic><topic>Influenza B virus - isolation & purification</topic><topic>Influenza, Human - diagnosis</topic><topic>Influenza, Human - drug therapy</topic><topic>Influenza, Human - epidemiology</topic><topic>Influenza, Human - immunology</topic><topic>Influenza, Human - physiopathology</topic><topic>Inpatients</topic><topic>Male</topic><topic>New South Wales - epidemiology</topic><topic>Population Surveillance</topic><topic>Prospective Studies</topic><topic>Social impact</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iskander, Mary</creatorcontrib><creatorcontrib>Kesson, Alison</creatorcontrib><creatorcontrib>Dwyer, Dominic</creatorcontrib><creatorcontrib>Rost, Laura</creatorcontrib><creatorcontrib>Pym, Margaret</creatorcontrib><creatorcontrib>Wang, Han</creatorcontrib><creatorcontrib>McCaskill, Mary</creatorcontrib><creatorcontrib>Booy, Robert</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of paediatrics and child health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iskander, Mary</au><au>Kesson, Alison</au><au>Dwyer, Dominic</au><au>Rost, Laura</au><au>Pym, Margaret</au><au>Wang, Han</au><au>McCaskill, Mary</au><au>Booy, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The burden of influenza in children under 5 years admitted to the Children's Hospital at Westmead in the winter of 2006</atitle><jtitle>Journal of paediatrics and child health</jtitle><addtitle>J Paediatr Child Health</addtitle><date>2009-12</date><risdate>2009</risdate><volume>45</volume><issue>12</issue><spage>698</spage><epage>703</epage><pages>698-703</pages><issn>1034-4810</issn><eissn>1440-1754</eissn><abstract>Objective: Active surveillance to determine influenza disease burden in children admitted to hospital with influenza‐like illness (ILI).
Methods: A prospective hospital‐based cohort study conducted June–October 2006 in children <5 years hospitalised at The Children's Hospital at Westmead with ILI (fever and respiratory symptoms). Influenza and other viral infections were diagnosed either by antigen detection using immunofluorescence or nucleic acid amplification testing of nasopharyngeal aspirates. Data were collected using researcher‐administered questionnaires. Main outcome measures include proportion of hospitalisations with influenza, vaccination and treatment, risk factors for influenza and associated medical and social burdens.
Results: Data on 275 children with ILI aged <5 years were analysed. Thirty‐one (11%) children with ILI had influenza (22 had influenza A and 9 had influenza B). Thirty‐five percent were under 6 months of age and 61% under 1 year. Twenty‐nine percent of children with influenza A were born prematurely. The mean duration of hospital stay for influenza was 2.8 days (95% confidence interval 2.1–3.4) and 26% had a lumbar puncture. Although 68% received intravenous antibiotics, only 3% (one case) was given an antiviral. Eighty‐four percent had visited their local doctor before admission and all came through the emergency department. On average, in one‐third (32%) of families of children with influenza a parent developed, ILI during admission or soon after hospital discharge resulted in an average of 3.2 days of work absenteeism. Only 3.5% (7/199) of children older than 6 months with ILI received any influenza vaccination.
Conclusions: Both the burden of influenza in childhood morbidity and its social impact are substantial. There is considerable room for improvement in both the prevention and early recognition (trigger treatment with antivirals) of influenza. Our data will inform decisions regarding the value of a universal influenza vaccine programme.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>19895431</pmid><doi>10.1111/j.1440-1754.2009.01597.x</doi><tpages>6</tpages></addata></record> |
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| subjects | child Child, Preschool Children & youth Cohort Studies Cost of Illness Female hospitalizatioin Hospitalization Hospitals, Pediatric Humans Immunization Infant Infant, Newborn Influenza Influenza A virus - isolation & purification Influenza B virus - isolation & purification Influenza, Human - diagnosis Influenza, Human - drug therapy Influenza, Human - epidemiology Influenza, Human - immunology Influenza, Human - physiopathology Inpatients Male New South Wales - epidemiology Population Surveillance Prospective Studies Social impact |
| title | The burden of influenza in children under 5 years admitted to the Children's Hospital at Westmead in the winter of 2006 |
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