"Primatization" of Recombinant Antibodies for Immunotherapy of Human Diseases: A Macaque/Human Chimeric Antibody Against Human CD4

Immunoglobulin variable region genes from non-human primates, cynomolgus macaques, were shown to have 85%–98% homology with human immunoglobulin sequences and yet macaques are phylogenetically distant enough to respond against conserved human antigens. Immunoglobulin genes were isolated from monkeys...

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Veröffentlicht in:	Bio/Technology 1992-11, Vol.10 (11), p.1455-1460
Hauptverfasser:	Newman, Roland, Alberts, James, Anderson, Darrell, Carner, Kristin, Heard, Cheryl, Norton, Frank, Raab, Ron, Reff, Mitchell, Shuey, Steve, Hanna, Nabil
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animals Antibodies, Monoclonal - analysis Antibodies, Monoclonal - therapeutic use Base Sequence Bioinformatics Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology CD4 Antigens - immunology Cloning, Molecular Humans Immunoglobulins - genetics Immunotherapy - methods Life Sciences Macaca fascicularis Molecular Sequence Data Recombinant Proteins - analysis Recombinant Proteins - therapeutic use research-paper Sequence Alignment Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid T-Lymphocytes - immunology
Online-Zugang:	Volltext
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