Controlled release application of multilamellar vesicles: a novel drug delivery approach

A novel multilamellar vesicular delivery system was developed for the controlled release application. Multilamellar vesicles were prepared by thin film hydration and converted into proliposomes by freeze-drying. A model drug metoclopramide, a highly hydrophilic drug, was successfully encapsulated in...

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Veröffentlicht in:	Drug delivery 2010-02, Vol.17 (2), p.92-101
Hauptverfasser:	Agnihotri, Sunil A., Soppimath, Kumaresh S., Betageri, Guru V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Calorimetry, Differential Scanning - methods Chemistry, Pharmaceutical controlled release Drug Carriers Drug Compounding drug delivery Drug Delivery Systems Drug Stability Excipients - administration & dosage Excipients - pharmacokinetics Membranes, Artificial metoclopramide Microscopy, Electron, Scanning multilamellar vesicles Multiparticulate systems Particle Size Phospholipids - chemistry Polymers - chemistry Polyvinyl Alcohol - chemistry proliposomes Solubility - drug effects Surface Properties Thermogravimetry - methods
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