Developing a Trace Level GC-MS Method for Detecting Methylhydrazine in an Experimental Drug Substance

Methylhydrazine (NH2NHCH3, CAS 60-34-4) is a highly reactive reducing agent used as an intermediate for synthesizing an experimental drug substance. Methylhydrazine is a known mutagen, an animal carcinogen, and a suspected human carcinogen. A gas chromatography-mass spectrometry method was developed...

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Veröffentlicht in:	Journal of chromatographic science 2010-04, Vol.48 (4), p.299-302
Hauptverfasser:	Fortin, David T., Chen, Raymond
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetone - chemistry Drug Contamination Drug Stability Gas Chromatography-Mass Spectrometry - methods Monomethylhydrazine - analysis Monomethylhydrazine - chemistry Pharmaceutical Preparations - chemistry Reproducibility of Results Sensitivity and Specificity Solid Phase Extraction - methods Temperature
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