Shh Signaling Regulates Adrenocortical Development and Identifies Progenitors of Steroidogenic Lineages
The adrenal cortex is a critical steroidogenic endocrine tissue, generated at least in part from the coelomic epithelium of the urogenital ridge. Neither the intercellular signals that regulate cortical development and maintenance nor the lineage relationships within the adrenal are well defined. We...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2009-12, Vol.106 (50), p.21185-21190 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 21190 |
|---|---|
| container_issue | 50 |
| container_start_page | 21185 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 106 |
| creator | King, Peter Paul, Alex Laufer, Ed |
| description | The adrenal cortex is a critical steroidogenic endocrine tissue, generated at least in part from the coelomic epithelium of the urogenital ridge. Neither the intercellular signals that regulate cortical development and maintenance nor the lineage relationships within the adrenal are well defined. We have explored adrenal Shh activity and found that Shh is expressed in relatively undifferentiated steroidogenic cells, which signal to the overlying capsule and subjacent nonsteroidogenic mesenchyme cells that we also find are progenitors of steroidogenic lineages. Shh-expressing cells also generate all steroidogenic cell types, but not nonsteroidogenic ones. Shh mutant adrenals have a thin capsule and small cortex. Our findings both support a novel dual lineage, Shh-independent and Shh-dependent, model of adrenocortical development, and identify distinct populations of adrenocortical progenitor and candidate stem cells. |
| doi_str_mv | 10.1073/pnas.0909471106 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_733907253</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>25593448</jstor_id><sourcerecordid>25593448</sourcerecordid><originalsourceid>FETCH-LOGICAL-c566t-d29278bf06459c6c8bd60d94e1c30f95894547b7e2fa75932f140d6f0be763a63</originalsourceid><addsrcrecordid>eNqFkc1vEzEQxS0EoqFw5gRacUEcth1_ry9IVfmqFAlE4Gx5vd6NI2ed2rsV_Pc4JGqAC6exxr95fp6H0HMMFxgkvdyNJl-AAsUkxiAeoAUGhWvBFDxECwAi64YRdoae5LwBAMUbeIzOsFKcM0YXaFit19XKD6MJfhyqr26Yg5lcrq665MZoY5q8NaF65-5ciLutG6fKjF1105WT730hv6Q4uNFPMeUq9tVqcin67nfPVks_OjO4_BQ96k3I7tmxnqPvH95_u_5ULz9_vLm-WtaWCzHVHVFENm0PgnFlhW3aTkCnmMOWQl_cK8aZbKUjvZFcUdJjBp3ooXVSUCPoOXp70N3N7dZ1trhMJuhd8luTfupovP77ZvRrPcQ7XZ4VjSJF4PVRIMXb2eVJb322LgQzujhnLSlVIAmnhXz1D7mJcyqLzJpAsUUbsZe7PEA2xZyT6--tYND7CPU-Qn2KsEy8_PMHJ_6YWQGqI7CfPMkJzUETjBtekDf_QXQ_hzC5H1NhXxzYTS4R3sOEl_Uy1tBf9my7Zw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201403862</pqid></control><display><type>article</type><title>Shh Signaling Regulates Adrenocortical Development and Identifies Progenitors of Steroidogenic Lineages</title><source>MEDLINE</source><source>Jstor Complete Legacy</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>King, Peter ; Paul, Alex ; Laufer, Ed</creator><creatorcontrib>King, Peter ; Paul, Alex ; Laufer, Ed</creatorcontrib><description>The adrenal cortex is a critical steroidogenic endocrine tissue, generated at least in part from the coelomic epithelium of the urogenital ridge. Neither the intercellular signals that regulate cortical development and maintenance nor the lineage relationships within the adrenal are well defined. We have explored adrenal Shh activity and found that Shh is expressed in relatively undifferentiated steroidogenic cells, which signal to the overlying capsule and subjacent nonsteroidogenic mesenchyme cells that we also find are progenitors of steroidogenic lineages. Shh-expressing cells also generate all steroidogenic cell types, but not nonsteroidogenic ones. Shh mutant adrenals have a thin capsule and small cortex. Our findings both support a novel dual lineage, Shh-independent and Shh-dependent, model of adrenocortical development, and identify distinct populations of adrenocortical progenitor and candidate stem cells.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0909471106</identifier><identifier>PMID: 19955443</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Adrenal cortex ; Adrenal Cortex - chemistry ; Adrenal Cortex - growth & development ; Adrenal glands ; Animals ; Biological Sciences ; Brain ; Capsules ; Cell Differentiation ; Cell Lineage ; Cells ; Embryonic stem cells ; Gene expression ; Gene expression regulation ; Hedgehog Proteins - analysis ; Hedgehog Proteins - physiology ; Kruppel-Like Transcription Factors - analysis ; Male ; Mesenchymal stem cells ; Mice ; Mutation ; Neurons ; Progenitor cells ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Stem cells ; Stem Cells - cytology ; Steroids - biosynthesis ; Zinc Finger Protein GLI1</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (50), p.21185-21190</ispartof><rights>Copyright National Academy of Sciences Dec 15, 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-d29278bf06459c6c8bd60d94e1c30f95894547b7e2fa75932f140d6f0be763a63</citedby><cites>FETCH-LOGICAL-c566t-d29278bf06459c6c8bd60d94e1c30f95894547b7e2fa75932f140d6f0be763a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/106/50.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25593448$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25593448$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19955443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>King, Peter</creatorcontrib><creatorcontrib>Paul, Alex</creatorcontrib><creatorcontrib>Laufer, Ed</creatorcontrib><title>Shh Signaling Regulates Adrenocortical Development and Identifies Progenitors of Steroidogenic Lineages</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The adrenal cortex is a critical steroidogenic endocrine tissue, generated at least in part from the coelomic epithelium of the urogenital ridge. Neither the intercellular signals that regulate cortical development and maintenance nor the lineage relationships within the adrenal are well defined. We have explored adrenal Shh activity and found that Shh is expressed in relatively undifferentiated steroidogenic cells, which signal to the overlying capsule and subjacent nonsteroidogenic mesenchyme cells that we also find are progenitors of steroidogenic lineages. Shh-expressing cells also generate all steroidogenic cell types, but not nonsteroidogenic ones. Shh mutant adrenals have a thin capsule and small cortex. Our findings both support a novel dual lineage, Shh-independent and Shh-dependent, model of adrenocortical development, and identify distinct populations of adrenocortical progenitor and candidate stem cells.</description><subject>Adrenal cortex</subject><subject>Adrenal Cortex - chemistry</subject><subject>Adrenal Cortex - growth & development</subject><subject>Adrenal glands</subject><subject>Animals</subject><subject>Biological Sciences</subject><subject>Brain</subject><subject>Capsules</subject><subject>Cell Differentiation</subject><subject>Cell Lineage</subject><subject>Cells</subject><subject>Embryonic stem cells</subject><subject>Gene expression</subject><subject>Gene expression regulation</subject><subject>Hedgehog Proteins - analysis</subject><subject>Hedgehog Proteins - physiology</subject><subject>Kruppel-Like Transcription Factors - analysis</subject><subject>Male</subject><subject>Mesenchymal stem cells</subject><subject>Mice</subject><subject>Mutation</subject><subject>Neurons</subject><subject>Progenitor cells</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Signal Transduction</subject><subject>Stem cells</subject><subject>Stem Cells - cytology</subject><subject>Steroids - biosynthesis</subject><subject>Zinc Finger Protein GLI1</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1vEzEQxS0EoqFw5gRacUEcth1_ry9IVfmqFAlE4Gx5vd6NI2ed2rsV_Pc4JGqAC6exxr95fp6H0HMMFxgkvdyNJl-AAsUkxiAeoAUGhWvBFDxECwAi64YRdoae5LwBAMUbeIzOsFKcM0YXaFit19XKD6MJfhyqr26Yg5lcrq665MZoY5q8NaF65-5ciLutG6fKjF1105WT730hv6Q4uNFPMeUq9tVqcin67nfPVks_OjO4_BQ96k3I7tmxnqPvH95_u_5ULz9_vLm-WtaWCzHVHVFENm0PgnFlhW3aTkCnmMOWQl_cK8aZbKUjvZFcUdJjBp3ooXVSUCPoOXp70N3N7dZ1trhMJuhd8luTfupovP77ZvRrPcQ7XZ4VjSJF4PVRIMXb2eVJb322LgQzujhnLSlVIAmnhXz1D7mJcyqLzJpAsUUbsZe7PEA2xZyT6--tYND7CPU-Qn2KsEy8_PMHJ_6YWQGqI7CfPMkJzUETjBtekDf_QXQ_hzC5H1NhXxzYTS4R3sOEl_Uy1tBf9my7Zw</recordid><startdate>20091215</startdate><enddate>20091215</enddate><creator>King, Peter</creator><creator>Paul, Alex</creator><creator>Laufer, Ed</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20091215</creationdate><title>Shh Signaling Regulates Adrenocortical Development and Identifies Progenitors of Steroidogenic Lineages</title><author>King, Peter ; Paul, Alex ; Laufer, Ed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-d29278bf06459c6c8bd60d94e1c30f95894547b7e2fa75932f140d6f0be763a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adrenal cortex</topic><topic>Adrenal Cortex - chemistry</topic><topic>Adrenal Cortex - growth & development</topic><topic>Adrenal glands</topic><topic>Animals</topic><topic>Biological Sciences</topic><topic>Brain</topic><topic>Capsules</topic><topic>Cell Differentiation</topic><topic>Cell Lineage</topic><topic>Cells</topic><topic>Embryonic stem cells</topic><topic>Gene expression</topic><topic>Gene expression regulation</topic><topic>Hedgehog Proteins - analysis</topic><topic>Hedgehog Proteins - physiology</topic><topic>Kruppel-Like Transcription Factors - analysis</topic><topic>Male</topic><topic>Mesenchymal stem cells</topic><topic>Mice</topic><topic>Mutation</topic><topic>Neurons</topic><topic>Progenitor cells</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Signal Transduction</topic><topic>Stem cells</topic><topic>Stem Cells - cytology</topic><topic>Steroids - biosynthesis</topic><topic>Zinc Finger Protein GLI1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>King, Peter</creatorcontrib><creatorcontrib>Paul, Alex</creatorcontrib><creatorcontrib>Laufer, Ed</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>King, Peter</au><au>Paul, Alex</au><au>Laufer, Ed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Shh Signaling Regulates Adrenocortical Development and Identifies Progenitors of Steroidogenic Lineages</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2009-12-15</date><risdate>2009</risdate><volume>106</volume><issue>50</issue><spage>21185</spage><epage>21190</epage><pages>21185-21190</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>The adrenal cortex is a critical steroidogenic endocrine tissue, generated at least in part from the coelomic epithelium of the urogenital ridge. Neither the intercellular signals that regulate cortical development and maintenance nor the lineage relationships within the adrenal are well defined. We have explored adrenal Shh activity and found that Shh is expressed in relatively undifferentiated steroidogenic cells, which signal to the overlying capsule and subjacent nonsteroidogenic mesenchyme cells that we also find are progenitors of steroidogenic lineages. Shh-expressing cells also generate all steroidogenic cell types, but not nonsteroidogenic ones. Shh mutant adrenals have a thin capsule and small cortex. Our findings both support a novel dual lineage, Shh-independent and Shh-dependent, model of adrenocortical development, and identify distinct populations of adrenocortical progenitor and candidate stem cells.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>19955443</pmid><doi>10.1073/pnas.0909471106</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (50), p.21185-21190 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733907253 |
| source | MEDLINE; Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Adrenal cortex Adrenal Cortex - chemistry Adrenal Cortex - growth & development Adrenal glands Animals Biological Sciences Brain Capsules Cell Differentiation Cell Lineage Cells Embryonic stem cells Gene expression Gene expression regulation Hedgehog Proteins - analysis Hedgehog Proteins - physiology Kruppel-Like Transcription Factors - analysis Male Mesenchymal stem cells Mice Mutation Neurons Progenitor cells Rats Rats, Sprague-Dawley Signal Transduction Stem cells Stem Cells - cytology Steroids - biosynthesis Zinc Finger Protein GLI1 |
| title | Shh Signaling Regulates Adrenocortical Development and Identifies Progenitors of Steroidogenic Lineages |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T04%3A15%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Shh%20Signaling%20Regulates%20Adrenocortical%20Development%20and%20Identifies%20Progenitors%20of%20Steroidogenic%20Lineages&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=King,%20Peter&rft.date=2009-12-15&rft.volume=106&rft.issue=50&rft.spage=21185&rft.epage=21190&rft.pages=21185-21190&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.0909471106&rft_dat=%3Cjstor_proqu%3E25593448%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=201403862&rft_id=info:pmid/19955443&rft_jstor_id=25593448&rfr_iscdi=true |