Sulphonamides as Inhibitors of Protein Tyrosine Phosphatase 1B: A Three-Dimensional Quantitative Structure–Activity Relationship Study Using Self-Organizing Molecular Field Analysis Approach

Protein tyrosine phosphatase 1B (PTP 1B), a cytosolic PTP involved in down-regulation of receptor tyrosine kinase activity following stimulation of the insulin or leptin receptors. Thus, PTP 1B inhibitors could potentially ameliorate insulin resistance and normalize plasma glucose and insulin levels...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2010/04/01, Vol.58(4), pp.526-532
Hauptverfasser:	Thareja, Suresh, Kokil, Ganesh Rajendra, Aggarwal, Saurabh, Bhardwaj, Tilak Raj, Kumar, Manoj
Format:	Artikel
Sprache:	eng
Schlagworte:	diabetes Diabetes Mellitus, Type 2 - drug therapy Humans insulin Models, Molecular Molecular Structure Protein Binding protein tyrosine phosphatase 1B Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors Protein Tyrosine Phosphatase, Non-Receptor Type 1 - chemistry Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism Quantitative Structure-Activity Relationship self-organizing molecular field analysis Sulfonamides - chemistry Sulfonamides - pharmacology sulphonamide three-dimensional quantitative structure–activity relationship
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