Does vitamin D supplementation of healthy Danish Caucasian girls affect bone turnover and bone mineralization?
Abstract Introduction A high peak bone mass may be essential for reducing the risk of osteoporosis later in life and a sufficient vitamin D level during puberty may be necessary for optimal bone accretion and obtaining a high peak bone mass. Dietary intake and synthesis during winter of vitamin D mi...
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| Veröffentlicht in: | Bone (New York, N.Y.) N.Y.), 2010-02, Vol.46 (2), p.432-439 |
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| creator | Mølgaard, C Larnkjær, A Cashman, K.D Lamberg-Allardt, C Jakobsen, J Michaelsen, K.F |
| description | Abstract Introduction A high peak bone mass may be essential for reducing the risk of osteoporosis later in life and a sufficient vitamin D level during puberty may be necessary for optimal bone accretion and obtaining a high peak bone mass. Dietary intake and synthesis during winter of vitamin D might be limited but the effect of vitamin D supplementation in adolescence on bone mass is not well established. Objective To investigate the effect of supplementation with 5 and 10 μg/day vitamin D3 for 12 months in 11- to 12-year-old girls on bone mass and bone turnover as well as the possible influence of VDR and ER genotype on the effect of the supplementation. Methods The girls ( n = 221) were randomized to receive either 5 μg or 10 μg vitamin D3 supplementation per day or placebo for 12 months. Whole body and lumbar spine bone mass measured by DXA and pubertal status were determined at baseline and after 12 months whereas physical activity and dietary intake of calcium and vitamin D were assessed at baseline. Serum (S) 25-hydroxyvitamin D (25OHD), S-osteocalcin, S-parathyroid hormone, S-calcium, S-inorganic phosphate, urinary (U) pyridinoline (Pyr) and deoxpyridinoline (Dpyr) were measured at baseline and after 6 and 12 months. Results The S-25OHD concentration increased ( p < 0.001) relative to the baseline values in the groups receiving either 5 μg/day (mean ± SD; 11.0 ± 10.3 nmol/l, baseline 41.9 ± 17.6 nmol/l) or 10 μg/day (13.3 ± 11.8 nmol/l, baseline 44.4 ± 16.6 nmol/l) vitamin D3 for 12 months compared to placebo (−3.1 ± 9.8 nmol/l, baseline 43.4 ± 17.1 nmol/l). There was no effect of vitamin D-supplementation on biomarkers for bone turnover or on whole body or spine bone mineral augmentation. However, vitamin D supplementation increased whole body bone mineral density (BMD) ( p = 0.007) and bone mineral content (BMC) ( p = 0.048) in the FF VDR genotype but not in the Ff or ff VDR genotypes. Conclusion Supplementation with vitamin D (5 or 10 μg/day) over 12 months increased the S-25OHD concentration but there was no effect on indices of bone health in the entire group of girls. However, there was an effect on BMD for a subgroup with the FF VDR genotype indicating an influence of genotype. |
| doi_str_mv | 10.1016/j.bone.2009.08.056 |
| format | Article |
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Dietary intake and synthesis during winter of vitamin D might be limited but the effect of vitamin D supplementation in adolescence on bone mass is not well established. Objective To investigate the effect of supplementation with 5 and 10 μg/day vitamin D3 for 12 months in 11- to 12-year-old girls on bone mass and bone turnover as well as the possible influence of VDR and ER genotype on the effect of the supplementation. Methods The girls ( n = 221) were randomized to receive either 5 μg or 10 μg vitamin D3 supplementation per day or placebo for 12 months. Whole body and lumbar spine bone mass measured by DXA and pubertal status were determined at baseline and after 12 months whereas physical activity and dietary intake of calcium and vitamin D were assessed at baseline. Serum (S) 25-hydroxyvitamin D (25OHD), S-osteocalcin, S-parathyroid hormone, S-calcium, S-inorganic phosphate, urinary (U) pyridinoline (Pyr) and deoxpyridinoline (Dpyr) were measured at baseline and after 6 and 12 months. Results The S-25OHD concentration increased ( p < 0.001) relative to the baseline values in the groups receiving either 5 μg/day (mean ± SD; 11.0 ± 10.3 nmol/l, baseline 41.9 ± 17.6 nmol/l) or 10 μg/day (13.3 ± 11.8 nmol/l, baseline 44.4 ± 16.6 nmol/l) vitamin D3 for 12 months compared to placebo (−3.1 ± 9.8 nmol/l, baseline 43.4 ± 17.1 nmol/l). There was no effect of vitamin D-supplementation on biomarkers for bone turnover or on whole body or spine bone mineral augmentation. However, vitamin D supplementation increased whole body bone mineral density (BMD) ( p = 0.007) and bone mineral content (BMC) ( p = 0.048) in the FF VDR genotype but not in the Ff or ff VDR genotypes. Conclusion Supplementation with vitamin D (5 or 10 μg/day) over 12 months increased the S-25OHD concentration but there was no effect on indices of bone health in the entire group of girls. However, there was an effect on BMD for a subgroup with the FF VDR genotype indicating an influence of genotype.</description><identifier>ISSN: 8756-3282</identifier><identifier>EISSN: 1873-2763</identifier><identifier>DOI: 10.1016/j.bone.2009.08.056</identifier><identifier>PMID: 19735754</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adolescent ; Adolescent girls ; Biological and medical sciences ; Bone and Bones - drug effects ; Bone and Bones - physiology ; Bone Density - drug effects ; Bone mass ; Bone Remodeling - drug effects ; Calcification, Physiologic - drug effects ; Cell physiology ; Cholecalciferol - administration & dosage ; Cholecalciferol - pharmacology ; Denmark ; Dietary Supplements ; European Continental Ancestry Group ; Female ; Fundamental and applied biological sciences. Psychology ; Genotype ; Health ; Humans ; Mineralization, calcification ; Molecular and cellular biology ; Orthopedics ; Polymorphism, Genetic ; Receptors, Calcitriol - genetics ; Receptors, Estrogen - genetics ; Skeleton and joints ; Time Factors ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: osteoarticular system, musculoskeletal system ; Vitamin D receptor genotype ; Vitamin D supplementation</subject><ispartof>Bone (New York, N.Y.), 2010-02, Vol.46 (2), p.432-439</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>(c) 2009 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-7dad63bdbdd36a41e7c8f43035a2509ba3c9c2950ededfa106e61b4a6438e93c3</citedby><cites>FETCH-LOGICAL-c506t-7dad63bdbdd36a41e7c8f43035a2509ba3c9c2950ededfa106e61b4a6438e93c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bone.2009.08.056$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22474765$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19735754$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mølgaard, C</creatorcontrib><creatorcontrib>Larnkjær, A</creatorcontrib><creatorcontrib>Cashman, K.D</creatorcontrib><creatorcontrib>Lamberg-Allardt, C</creatorcontrib><creatorcontrib>Jakobsen, J</creatorcontrib><creatorcontrib>Michaelsen, K.F</creatorcontrib><title>Does vitamin D supplementation of healthy Danish Caucasian girls affect bone turnover and bone mineralization?</title><title>Bone (New York, N.Y.)</title><addtitle>Bone</addtitle><description>Abstract Introduction A high peak bone mass may be essential for reducing the risk of osteoporosis later in life and a sufficient vitamin D level during puberty may be necessary for optimal bone accretion and obtaining a high peak bone mass. Dietary intake and synthesis during winter of vitamin D might be limited but the effect of vitamin D supplementation in adolescence on bone mass is not well established. Objective To investigate the effect of supplementation with 5 and 10 μg/day vitamin D3 for 12 months in 11- to 12-year-old girls on bone mass and bone turnover as well as the possible influence of VDR and ER genotype on the effect of the supplementation. Methods The girls ( n = 221) were randomized to receive either 5 μg or 10 μg vitamin D3 supplementation per day or placebo for 12 months. Whole body and lumbar spine bone mass measured by DXA and pubertal status were determined at baseline and after 12 months whereas physical activity and dietary intake of calcium and vitamin D were assessed at baseline. Serum (S) 25-hydroxyvitamin D (25OHD), S-osteocalcin, S-parathyroid hormone, S-calcium, S-inorganic phosphate, urinary (U) pyridinoline (Pyr) and deoxpyridinoline (Dpyr) were measured at baseline and after 6 and 12 months. Results The S-25OHD concentration increased ( p < 0.001) relative to the baseline values in the groups receiving either 5 μg/day (mean ± SD; 11.0 ± 10.3 nmol/l, baseline 41.9 ± 17.6 nmol/l) or 10 μg/day (13.3 ± 11.8 nmol/l, baseline 44.4 ± 16.6 nmol/l) vitamin D3 for 12 months compared to placebo (−3.1 ± 9.8 nmol/l, baseline 43.4 ± 17.1 nmol/l). There was no effect of vitamin D-supplementation on biomarkers for bone turnover or on whole body or spine bone mineral augmentation. However, vitamin D supplementation increased whole body bone mineral density (BMD) ( p = 0.007) and bone mineral content (BMC) ( p = 0.048) in the FF VDR genotype but not in the Ff or ff VDR genotypes. Conclusion Supplementation with vitamin D (5 or 10 μg/day) over 12 months increased the S-25OHD concentration but there was no effect on indices of bone health in the entire group of girls. However, there was an effect on BMD for a subgroup with the FF VDR genotype indicating an influence of genotype.</description><subject>Adolescent</subject><subject>Adolescent girls</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - physiology</subject><subject>Bone Density - drug effects</subject><subject>Bone mass</subject><subject>Bone Remodeling - drug effects</subject><subject>Calcification, Physiologic - drug effects</subject><subject>Cell physiology</subject><subject>Cholecalciferol - administration & dosage</subject><subject>Cholecalciferol - pharmacology</subject><subject>Denmark</subject><subject>Dietary Supplements</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotype</subject><subject>Health</subject><subject>Humans</subject><subject>Mineralization, calcification</subject><subject>Molecular and cellular biology</subject><subject>Orthopedics</subject><subject>Polymorphism, Genetic</subject><subject>Receptors, Calcitriol - genetics</subject><subject>Receptors, Estrogen - genetics</subject><subject>Skeleton and joints</subject><subject>Time Factors</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><subject>Vitamin D receptor genotype</subject><subject>Vitamin D supplementation</subject><issn>8756-3282</issn><issn>1873-2763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk2P0zAQhiMEYrsLf4AD8gVxShjHiZ1IiBVqlw9pJQ7A2ZrYE-qSOsVOKpVfj0MrkDhwsmQ983rm8WTZMw4FBy5f7Ypu9FSUAG0BTQG1fJCteKNEXiopHmarRtUyF2VTXmXXMe4AQLSKP86ueKtErepqlfnNSJEd3YR759mGxflwGGhPfsLJjZ6NPdsSDtP2xDboXdyyNc4Go0PPvrkwRIZ9T2ZiSytsmoMfjxQYenu-SakUcHA_f8fdPske9ThEeno5b7Kv7-6-rD_k95_ef1y_vc9NDXLKlUUrRWc7a4XEipMyTV8JEDWWNbQdCtOasq2BLNkeOUiSvKtQVqKhVhhxk7085x7C-GOmOOm9i4aGAT2Nc9RKiBYqqKpElmfShDHGQL0-BLfHcNIc9KJZ7_QyiV40a2h00pyKnl_i525P9m_JxWsCXlwAjAaHPqA3Lv7hyrJSlZJ14l6fOUoyjo6CjsaRN2RdSFa1Hd3_-3jzT7kZnHfpxe90orgb038kzZrrWGrQn5eFWPYBWuBNUyvxC1ojsjM</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Mølgaard, C</creator><creator>Larnkjær, A</creator><creator>Cashman, K.D</creator><creator>Lamberg-Allardt, C</creator><creator>Jakobsen, J</creator><creator>Michaelsen, K.F</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100201</creationdate><title>Does vitamin D supplementation of healthy Danish Caucasian girls affect bone turnover and bone mineralization?</title><author>Mølgaard, C ; Larnkjær, A ; Cashman, K.D ; Lamberg-Allardt, C ; Jakobsen, J ; Michaelsen, K.F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-7dad63bdbdd36a41e7c8f43035a2509ba3c9c2950ededfa106e61b4a6438e93c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adolescent girls</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - drug effects</topic><topic>Bone and Bones - physiology</topic><topic>Bone Density - drug effects</topic><topic>Bone mass</topic><topic>Bone Remodeling - drug effects</topic><topic>Calcification, Physiologic - drug effects</topic><topic>Cell physiology</topic><topic>Cholecalciferol - administration & dosage</topic><topic>Cholecalciferol - pharmacology</topic><topic>Denmark</topic><topic>Dietary Supplements</topic><topic>European Continental Ancestry Group</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotype</topic><topic>Health</topic><topic>Humans</topic><topic>Mineralization, calcification</topic><topic>Molecular and cellular biology</topic><topic>Orthopedics</topic><topic>Polymorphism, Genetic</topic><topic>Receptors, Calcitriol - genetics</topic><topic>Receptors, Estrogen - genetics</topic><topic>Skeleton and joints</topic><topic>Time Factors</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><topic>Vitamin D receptor genotype</topic><topic>Vitamin D supplementation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mølgaard, C</creatorcontrib><creatorcontrib>Larnkjær, A</creatorcontrib><creatorcontrib>Cashman, K.D</creatorcontrib><creatorcontrib>Lamberg-Allardt, C</creatorcontrib><creatorcontrib>Jakobsen, J</creatorcontrib><creatorcontrib>Michaelsen, K.F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bone (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mølgaard, C</au><au>Larnkjær, A</au><au>Cashman, K.D</au><au>Lamberg-Allardt, C</au><au>Jakobsen, J</au><au>Michaelsen, K.F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does vitamin D supplementation of healthy Danish Caucasian girls affect bone turnover and bone mineralization?</atitle><jtitle>Bone (New York, N.Y.)</jtitle><addtitle>Bone</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>46</volume><issue>2</issue><spage>432</spage><epage>439</epage><pages>432-439</pages><issn>8756-3282</issn><eissn>1873-2763</eissn><abstract>Abstract Introduction A high peak bone mass may be essential for reducing the risk of osteoporosis later in life and a sufficient vitamin D level during puberty may be necessary for optimal bone accretion and obtaining a high peak bone mass. Dietary intake and synthesis during winter of vitamin D might be limited but the effect of vitamin D supplementation in adolescence on bone mass is not well established. Objective To investigate the effect of supplementation with 5 and 10 μg/day vitamin D3 for 12 months in 11- to 12-year-old girls on bone mass and bone turnover as well as the possible influence of VDR and ER genotype on the effect of the supplementation. Methods The girls ( n = 221) were randomized to receive either 5 μg or 10 μg vitamin D3 supplementation per day or placebo for 12 months. Whole body and lumbar spine bone mass measured by DXA and pubertal status were determined at baseline and after 12 months whereas physical activity and dietary intake of calcium and vitamin D were assessed at baseline. Serum (S) 25-hydroxyvitamin D (25OHD), S-osteocalcin, S-parathyroid hormone, S-calcium, S-inorganic phosphate, urinary (U) pyridinoline (Pyr) and deoxpyridinoline (Dpyr) were measured at baseline and after 6 and 12 months. Results The S-25OHD concentration increased ( p < 0.001) relative to the baseline values in the groups receiving either 5 μg/day (mean ± SD; 11.0 ± 10.3 nmol/l, baseline 41.9 ± 17.6 nmol/l) or 10 μg/day (13.3 ± 11.8 nmol/l, baseline 44.4 ± 16.6 nmol/l) vitamin D3 for 12 months compared to placebo (−3.1 ± 9.8 nmol/l, baseline 43.4 ± 17.1 nmol/l). There was no effect of vitamin D-supplementation on biomarkers for bone turnover or on whole body or spine bone mineral augmentation. However, vitamin D supplementation increased whole body bone mineral density (BMD) ( p = 0.007) and bone mineral content (BMC) ( p = 0.048) in the FF VDR genotype but not in the Ff or ff VDR genotypes. Conclusion Supplementation with vitamin D (5 or 10 μg/day) over 12 months increased the S-25OHD concentration but there was no effect on indices of bone health in the entire group of girls. However, there was an effect on BMD for a subgroup with the FF VDR genotype indicating an influence of genotype.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>19735754</pmid><doi>10.1016/j.bone.2009.08.056</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adolescent girls Biological and medical sciences Bone and Bones - drug effects Bone and Bones - physiology Bone Density - drug effects Bone mass Bone Remodeling - drug effects Calcification, Physiologic - drug effects Cell physiology Cholecalciferol - administration & dosage Cholecalciferol - pharmacology Denmark Dietary Supplements European Continental Ancestry Group Female Fundamental and applied biological sciences. Psychology Genotype Health Humans Mineralization, calcification Molecular and cellular biology Orthopedics Polymorphism, Genetic Receptors, Calcitriol - genetics Receptors, Estrogen - genetics Skeleton and joints Time Factors Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: osteoarticular system, musculoskeletal system Vitamin D receptor genotype Vitamin D supplementation |
| title | Does vitamin D supplementation of healthy Danish Caucasian girls affect bone turnover and bone mineralization? |
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