Early diagnostic accuracy and pathophysiologic relevance of an autopsy-confirmed Alzheimer's disease peripheral biomarker

Abstract Treatment of Alzheimer's disease (AD) and the discovery of promising drug candidates depend on early diagnosis. Few currently available diagnostic tests have significantly improved this early uncertainty, while the “gold standard” diagnosis continues to require clinical dementia in lif...

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Veröffentlicht in:	Neurobiology of aging 2010-06, Vol.31 (6), p.889-900
Hauptverfasser:	Khan, Tapan Kumar, Alkon, Daniel L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta-Peptides - pharmacology Autopsy Biological and medical sciences Bradykinin Bradykinin - pharmacology Brain - pathology Cells, Cultured Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia - diagnosis Development. Senescence. Regeneration. Transplantation Erk1/2 phosphorylation Female Fibroblasts - drug effects Fundamental and applied biological sciences. Psychology Humans Internal Medicine Male Medical sciences Middle Aged Mitogen-Activated Protein Kinase 3 - metabolism Neurofibrillary Tangles - pathology Neurology Peptide Fragments - pharmacology Peripheral biomarker PKC Plaque, Amyloid - pathology Reproducibility of Results Skin - pathology Vasodilator Agents - pharmacology Vertebrates: nervous system and sense organs
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