Analysis of Nifedipine Absorption from Soft Gelatin Capsules Using PBPK Modeling and Biorelevant Dissolution Testing

Delayed absorption of nifedipine when administered as a 20mg immediate release soft gelatin capsule to fasted volunteers has been reported. Physiologically based pharmacokinetic (PBPK) modeling and in vitro dissolution data were used to explore our hypothesis that at high doses of nifedipine it prec...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 2010-06, Vol.99 (6), p.2899-2904
Hauptverfasser:	Thelen, Kirstin, Jantratid, Ekarat, Dressman, Jennifer B., Lippert, Jorg, Willmann, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Biological and medical sciences biorelevant media Capsules - chemistry Clinical Trials as Topic computational ADME dissolution Gelatin General pharmacology Humans Medical sciences nifedipine Nifedipine - administration & dosage PBPK modeling Pharmaceutical Preparations - administration & dosage Pharmaceutical technology. Pharmaceutical industry pharmacokinetics Pharmacology. Drug treatments Physical Phenomena PK-Sim precipitation Software solubility Stomach
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!