Synthesis of 2-Methylsulfanyl-1H-imidazoles as Novel Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)

α‐Aminoketone hydrochlorides 2a—d were synthesized by Dakin‐West reaction from L‐phenylalanine and L‐cyclohexylalanine followed by hydrolysis in acidic medium. Treatment of 2a—d with aqueous potassium thiocyanate afforded 1, 3‐imidazole‐2‐thiones 3a—d which were alkylated with methyl iodide to give...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2003-06, Vol.336 (3), p.175-180
Hauptverfasser:	Loksha, Yasser M., El-Badawi, Mahmoud A., El-Barbary, Ahmed A., Pedersen, Erik B., Nielsen, Claus
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line HIV-1 - drug effects Human immunodeficiency virus Human immunodeficiency virus 1 Humans Imidazole-2-thiones Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - pharmacology Magnetic Resonance Spectroscopy Non-nucleoside reverse transcriptase inhibitors Reverse Transcriptase Inhibitors - chemical synthesis Reverse Transcriptase Inhibitors - chemistry Reverse Transcriptase Inhibitors - pharmacology Structure-Activity Relationship α-Aminoketones
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