Transition metal complexes of 3-aryl-2-substituted 1,2-dihydroquinazolin-4(3H)-one derivatives: New class of analgesic and anti-inflammatory agents
Five-coordinate, neutral transition metal complexes of newly designed pyridine-2-ethyl-(3-carboxylideneamino)-3-(2-phenyl)-1,2-dihydroquinazolin-4(3H)-one ( L) were synthesized and characterized. The structure of ligand is confirmed by single crystal X-ray diffraction studies. The compounds were eva...
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| Veröffentlicht in: | European journal of medicinal chemistry 2010-06, Vol.45 (6), p.2277-2282 |
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| container_title | European journal of medicinal chemistry |
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| creator | Hoonur, Rekha S. Patil, Basavaraj R. Badiger, Dayananda S. Vadavi, Ramesh S. Gudasi, Kalagouda B. Dandawate, Prasad R. Ghaisas, Mahesh M. Padhye, Subhash B. Nethaji, Munirathinam |
| description | Five-coordinate, neutral transition metal complexes of newly designed pyridine-2-ethyl-(3-carboxylideneamino)-3-(2-phenyl)-1,2-dihydroquinazolin-4(3H)-one (
L) were synthesized and characterized. The structure of ligand is confirmed by single crystal X-ray diffraction studies. The compounds were evaluated for the anti-inflammatory activity by carrageenan-induced rat paw edema model while their analgesic activity was determined by acetic acid-induced writhing test in mice wherein the transition metal complexes were found to be more active than the free ligand.
Five-coordinate, neutral transition metal complexes of pyridine-2-ethyl-(3-carboxylideneamino)-3-(2-phenyl)-1,2-dihydroquinazolin-4(3H)-one (
L) were synthesized, characterized and screened for analgesic and anti-inflammatory activity wherein the copper complex showed most potent activity.
[Display omitted] |
| doi_str_mv | 10.1016/j.ejmech.2010.01.072 |
| format | Article |
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L) were synthesized and characterized. The structure of ligand is confirmed by single crystal X-ray diffraction studies. The compounds were evaluated for the anti-inflammatory activity by carrageenan-induced rat paw edema model while their analgesic activity was determined by acetic acid-induced writhing test in mice wherein the transition metal complexes were found to be more active than the free ligand.
Five-coordinate, neutral transition metal complexes of pyridine-2-ethyl-(3-carboxylideneamino)-3-(2-phenyl)-1,2-dihydroquinazolin-4(3H)-one (
L) were synthesized, characterized and screened for analgesic and anti-inflammatory activity wherein the copper complex showed most potent activity.
[Display omitted]</description><identifier>ISSN: 0223-5234</identifier><identifier>EISSN: 1768-3254</identifier><identifier>DOI: 10.1016/j.ejmech.2010.01.072</identifier><identifier>PMID: 20185211</identifier><identifier>CODEN: EJMCA5</identifier><language>eng</language><publisher>Kidlington: Elsevier Masson SAS</publisher><subject>Analgesic activity ; Analgesics ; Analgesics - chemistry ; Analgesics - pharmacology ; Analgesics - therapeutic use ; Animals ; Anti-inflammatory activity ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Crystallography, X-Ray ; Dihydroquinazoline ; Drug Design ; Edema - drug therapy ; Hydrazone ; Medical sciences ; Metal complex ; Mice ; Neuropharmacology ; Organometallic Compounds - chemistry ; Organometallic Compounds - pharmacology ; Organometallic Compounds - therapeutic use ; Pharmacology. Drug treatments ; Quinazolines - chemistry ; Rats ; Spectrum Analysis ; Transition Elements - chemistry</subject><ispartof>European journal of medicinal chemistry, 2010-06, Vol.45 (6), p.2277-2282</ispartof><rights>2010 Elsevier Masson SAS</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-aa43b47a7c573045e139f02c028a5358b545a51c77f2f19a38a1ca1a4648b0dd3</citedby><cites>FETCH-LOGICAL-c457t-aa43b47a7c573045e139f02c028a5358b545a51c77f2f19a38a1ca1a4648b0dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0223523410001194$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22701844$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20185211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoonur, Rekha S.</creatorcontrib><creatorcontrib>Patil, Basavaraj R.</creatorcontrib><creatorcontrib>Badiger, Dayananda S.</creatorcontrib><creatorcontrib>Vadavi, Ramesh S.</creatorcontrib><creatorcontrib>Gudasi, Kalagouda B.</creatorcontrib><creatorcontrib>Dandawate, Prasad R.</creatorcontrib><creatorcontrib>Ghaisas, Mahesh M.</creatorcontrib><creatorcontrib>Padhye, Subhash B.</creatorcontrib><creatorcontrib>Nethaji, Munirathinam</creatorcontrib><title>Transition metal complexes of 3-aryl-2-substituted 1,2-dihydroquinazolin-4(3H)-one derivatives: New class of analgesic and anti-inflammatory agents</title><title>European journal of medicinal chemistry</title><addtitle>Eur J Med Chem</addtitle><description>Five-coordinate, neutral transition metal complexes of newly designed pyridine-2-ethyl-(3-carboxylideneamino)-3-(2-phenyl)-1,2-dihydroquinazolin-4(3H)-one (
L) were synthesized and characterized. The structure of ligand is confirmed by single crystal X-ray diffraction studies. The compounds were evaluated for the anti-inflammatory activity by carrageenan-induced rat paw edema model while their analgesic activity was determined by acetic acid-induced writhing test in mice wherein the transition metal complexes were found to be more active than the free ligand.
Five-coordinate, neutral transition metal complexes of pyridine-2-ethyl-(3-carboxylideneamino)-3-(2-phenyl)-1,2-dihydroquinazolin-4(3H)-one (
L) were synthesized, characterized and screened for analgesic and anti-inflammatory activity wherein the copper complex showed most potent activity.
[Display omitted]</description><subject>Analgesic activity</subject><subject>Analgesics</subject><subject>Analgesics - chemistry</subject><subject>Analgesics - pharmacology</subject><subject>Analgesics - therapeutic use</subject><subject>Animals</subject><subject>Anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Crystallography, X-Ray</subject><subject>Dihydroquinazoline</subject><subject>Drug Design</subject><subject>Edema - drug therapy</subject><subject>Hydrazone</subject><subject>Medical sciences</subject><subject>Metal complex</subject><subject>Mice</subject><subject>Neuropharmacology</subject><subject>Organometallic Compounds - chemistry</subject><subject>Organometallic Compounds - pharmacology</subject><subject>Organometallic Compounds - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Quinazolines - chemistry</subject><subject>Rats</subject><subject>Spectrum Analysis</subject><subject>Transition Elements - chemistry</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-KFDEQxoMo7rj6BiJ9ERXMmL_TPR4EWdQVFr2s51CdVO9mSCdjJz06voYvbMYZ9eYhVAi_ryr1fYQ85mzJGV-92ixxM6K9XQpWnxhfslbcIQverjoqhVZ3yYIJIakWUp2RBzlvGGN6xdh9clYlnRacL8jP6wli9sWn2IxYIDQ2jduA3zE3aWgkhWkfqKB57nPxZS7oGv5SUOdv925KX2cf4UcKPlL1XF6-oCli43DyOyh-h_l18wm_NTZA_t0OIoQbzN7Wm6uneOrjEGAcoaRp38ANxpIfknsDhIyPTvWcfHn_7vrikl59_vDx4u0VtUq3hQIo2asWWqtbyZRGLtcDE5aJDrTUXa-VBs1t2w5i4GuQHXALHNRKdT1zTp6TZ8e-28MimIsZfbYYAkRMczatlN26k6yrpDqSdko5TziY7eTHao3hzBzSMBtzTMMc0jCMm5pGlT05DZj7Ed1f0R_7K_D0BEC2EIaahfX5HyfaSipVuTdHDqsdO4-TydZjtOj8hLYYl_z_f_ILg4yqzw</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Hoonur, Rekha S.</creator><creator>Patil, Basavaraj R.</creator><creator>Badiger, Dayananda S.</creator><creator>Vadavi, Ramesh S.</creator><creator>Gudasi, Kalagouda B.</creator><creator>Dandawate, Prasad R.</creator><creator>Ghaisas, Mahesh M.</creator><creator>Padhye, Subhash B.</creator><creator>Nethaji, Munirathinam</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100601</creationdate><title>Transition metal complexes of 3-aryl-2-substituted 1,2-dihydroquinazolin-4(3H)-one derivatives: New class of analgesic and anti-inflammatory agents</title><author>Hoonur, Rekha S. ; Patil, Basavaraj R. ; Badiger, Dayananda S. ; Vadavi, Ramesh S. ; Gudasi, Kalagouda B. ; Dandawate, Prasad R. ; Ghaisas, Mahesh M. ; Padhye, Subhash B. ; Nethaji, Munirathinam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-aa43b47a7c573045e139f02c028a5358b545a51c77f2f19a38a1ca1a4648b0dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Analgesic activity</topic><topic>Analgesics</topic><topic>Analgesics - chemistry</topic><topic>Analgesics - pharmacology</topic><topic>Analgesics - therapeutic use</topic><topic>Animals</topic><topic>Anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Crystallography, X-Ray</topic><topic>Dihydroquinazoline</topic><topic>Drug Design</topic><topic>Edema - drug therapy</topic><topic>Hydrazone</topic><topic>Medical sciences</topic><topic>Metal complex</topic><topic>Mice</topic><topic>Neuropharmacology</topic><topic>Organometallic Compounds - chemistry</topic><topic>Organometallic Compounds - pharmacology</topic><topic>Organometallic Compounds - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Quinazolines - chemistry</topic><topic>Rats</topic><topic>Spectrum Analysis</topic><topic>Transition Elements - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoonur, Rekha S.</creatorcontrib><creatorcontrib>Patil, Basavaraj R.</creatorcontrib><creatorcontrib>Badiger, Dayananda S.</creatorcontrib><creatorcontrib>Vadavi, Ramesh S.</creatorcontrib><creatorcontrib>Gudasi, Kalagouda B.</creatorcontrib><creatorcontrib>Dandawate, Prasad R.</creatorcontrib><creatorcontrib>Ghaisas, Mahesh M.</creatorcontrib><creatorcontrib>Padhye, Subhash B.</creatorcontrib><creatorcontrib>Nethaji, Munirathinam</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoonur, Rekha S.</au><au>Patil, Basavaraj R.</au><au>Badiger, Dayananda S.</au><au>Vadavi, Ramesh S.</au><au>Gudasi, Kalagouda B.</au><au>Dandawate, Prasad R.</au><au>Ghaisas, Mahesh M.</au><au>Padhye, Subhash B.</au><au>Nethaji, Munirathinam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transition metal complexes of 3-aryl-2-substituted 1,2-dihydroquinazolin-4(3H)-one derivatives: New class of analgesic and anti-inflammatory agents</atitle><jtitle>European journal of medicinal chemistry</jtitle><addtitle>Eur J Med Chem</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>45</volume><issue>6</issue><spage>2277</spage><epage>2282</epage><pages>2277-2282</pages><issn>0223-5234</issn><eissn>1768-3254</eissn><coden>EJMCA5</coden><abstract>Five-coordinate, neutral transition metal complexes of newly designed pyridine-2-ethyl-(3-carboxylideneamino)-3-(2-phenyl)-1,2-dihydroquinazolin-4(3H)-one (
L) were synthesized and characterized. The structure of ligand is confirmed by single crystal X-ray diffraction studies. The compounds were evaluated for the anti-inflammatory activity by carrageenan-induced rat paw edema model while their analgesic activity was determined by acetic acid-induced writhing test in mice wherein the transition metal complexes were found to be more active than the free ligand.
Five-coordinate, neutral transition metal complexes of pyridine-2-ethyl-(3-carboxylideneamino)-3-(2-phenyl)-1,2-dihydroquinazolin-4(3H)-one (
L) were synthesized, characterized and screened for analgesic and anti-inflammatory activity wherein the copper complex showed most potent activity.
[Display omitted]</abstract><cop>Kidlington</cop><pub>Elsevier Masson SAS</pub><pmid>20185211</pmid><doi>10.1016/j.ejmech.2010.01.072</doi><tpages>6</tpages></addata></record> |
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| ispartof | European journal of medicinal chemistry, 2010-06, Vol.45 (6), p.2277-2282 |
| issn | 0223-5234 1768-3254 |
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| subjects | Analgesic activity Analgesics Analgesics - chemistry Analgesics - pharmacology Analgesics - therapeutic use Animals Anti-inflammatory activity Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Crystallography, X-Ray Dihydroquinazoline Drug Design Edema - drug therapy Hydrazone Medical sciences Metal complex Mice Neuropharmacology Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Organometallic Compounds - therapeutic use Pharmacology. Drug treatments Quinazolines - chemistry Rats Spectrum Analysis Transition Elements - chemistry |
| title | Transition metal complexes of 3-aryl-2-substituted 1,2-dihydroquinazolin-4(3H)-one derivatives: New class of analgesic and anti-inflammatory agents |
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