Gastric emptying evaluation in children with erosive gastroesophageal reflux disease
Background/aims Delayed gastric emptying may be an important contributing factor to gastroesophageal reflux disease (GERD) in children, but there are limited data on its evaluation in children with erosive-GERD. This study aims to evaluate the gastric emptying of a solid meal in patients with erosiv...
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Veröffentlicht in: | Pediatric surgery international 2010-05, Vol.26 (5), p.473-478 |
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description | Background/aims
Delayed gastric emptying may be an important contributing factor to gastroesophageal reflux disease (GERD) in children, but there are limited data on its evaluation in children with erosive-GERD. This study aims to evaluate the gastric emptying of a solid meal in patients with erosive-GERD.
Methods
Nineteen patients (age range 8.79–17.9 years) with erosive esophagitis and 14 healthy controls (age range from 8.04 to 18.7 years) were compared. Esophagitis was graded according to Los Angeles classification. The gastric emptying was evaluated by
13
C-octanoic breath test, which was performed after a 344 kcal standardized solid test meal. Symptoms were evaluated using a standardized questionnaire.
Results
The two most prevalent symptoms were nausea and epigastric pain, which were reported by 12 (63.2%) patients. Irritable bowel syndrome was present in 26.3% (5/19). The median gastric emptying half-time in patients was 160 min (interquartile range [IQR] 140–174 min), which was not different from the controls’ figure (median 157 min, IQR 143–170 min). Additionally, the lag time and the gastric emptying coefficient were not significantly different between the study groups.
Conclusion
Delayed gastric emptying is not associated with erosive esophagitis in children with GERD, when compared to controls. |
doi_str_mv | 10.1007/s00383-010-2579-4 |
format | Article |
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Delayed gastric emptying may be an important contributing factor to gastroesophageal reflux disease (GERD) in children, but there are limited data on its evaluation in children with erosive-GERD. This study aims to evaluate the gastric emptying of a solid meal in patients with erosive-GERD.
Methods
Nineteen patients (age range 8.79–17.9 years) with erosive esophagitis and 14 healthy controls (age range from 8.04 to 18.7 years) were compared. Esophagitis was graded according to Los Angeles classification. The gastric emptying was evaluated by
13
C-octanoic breath test, which was performed after a 344 kcal standardized solid test meal. Symptoms were evaluated using a standardized questionnaire.
Results
The two most prevalent symptoms were nausea and epigastric pain, which were reported by 12 (63.2%) patients. Irritable bowel syndrome was present in 26.3% (5/19). The median gastric emptying half-time in patients was 160 min (interquartile range [IQR] 140–174 min), which was not different from the controls’ figure (median 157 min, IQR 143–170 min). Additionally, the lag time and the gastric emptying coefficient were not significantly different between the study groups.
Conclusion
Delayed gastric emptying is not associated with erosive esophagitis in children with GERD, when compared to controls.</description><identifier>ISSN: 0179-0358</identifier><identifier>EISSN: 1437-9813</identifier><identifier>DOI: 10.1007/s00383-010-2579-4</identifier><identifier>PMID: 20405273</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Breath Tests ; Case-Control Studies ; Chi-Square Distribution ; Child ; Endoscopy, Digestive System ; Female ; Gastric Emptying ; Gastroesophageal Reflux - physiopathology ; Humans ; Male ; Medicine ; Medicine & Public Health ; Original Article ; Pediatric Surgery ; Pediatrics ; Statistics, Nonparametric ; Surgery ; Surveys and Questionnaires</subject><ispartof>Pediatric surgery international, 2010-05, Vol.26 (5), p.473-478</ispartof><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-b306e3b2f5791c599c6f9f859d33f9d8f9cab8b6fe7e972e2a9bd8fd041a873c3</citedby><cites>FETCH-LOGICAL-c370t-b306e3b2f5791c599c6f9f859d33f9d8f9cab8b6fe7e972e2a9bd8fd041a873c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00383-010-2579-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00383-010-2579-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20405273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Machado, Rodrigo Strehl</creatorcontrib><creatorcontrib>Yamamoto, Érica</creatorcontrib><creatorcontrib>da Silva Patrício, Francy Reis</creatorcontrib><creatorcontrib>Reber, Marialice</creatorcontrib><creatorcontrib>Kawakami, Elisabete</creatorcontrib><title>Gastric emptying evaluation in children with erosive gastroesophageal reflux disease</title><title>Pediatric surgery international</title><addtitle>Pediatr Surg Int</addtitle><addtitle>Pediatr Surg Int</addtitle><description>Background/aims
Delayed gastric emptying may be an important contributing factor to gastroesophageal reflux disease (GERD) in children, but there are limited data on its evaluation in children with erosive-GERD. This study aims to evaluate the gastric emptying of a solid meal in patients with erosive-GERD.
Methods
Nineteen patients (age range 8.79–17.9 years) with erosive esophagitis and 14 healthy controls (age range from 8.04 to 18.7 years) were compared. Esophagitis was graded according to Los Angeles classification. The gastric emptying was evaluated by
13
C-octanoic breath test, which was performed after a 344 kcal standardized solid test meal. Symptoms were evaluated using a standardized questionnaire.
Results
The two most prevalent symptoms were nausea and epigastric pain, which were reported by 12 (63.2%) patients. Irritable bowel syndrome was present in 26.3% (5/19). The median gastric emptying half-time in patients was 160 min (interquartile range [IQR] 140–174 min), which was not different from the controls’ figure (median 157 min, IQR 143–170 min). Additionally, the lag time and the gastric emptying coefficient were not significantly different between the study groups.
Conclusion
Delayed gastric emptying is not associated with erosive esophagitis in children with GERD, when compared to controls.</description><subject>Adolescent</subject><subject>Breath Tests</subject><subject>Case-Control Studies</subject><subject>Chi-Square Distribution</subject><subject>Child</subject><subject>Endoscopy, Digestive System</subject><subject>Female</subject><subject>Gastric Emptying</subject><subject>Gastroesophageal Reflux - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Statistics, Nonparametric</subject><subject>Surgery</subject><subject>Surveys and Questionnaires</subject><issn>0179-0358</issn><issn>1437-9813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kMFKAzEQhoMotlYfwIsEL55WJ5vdJjlK0SoIXuo5ZLOzbcp2tya71b69Ka0KgqfA5Jt_Zj5CLhncMgBxFwC45AkwSNJcqCQ7IkOWcZEoyfgxGQKLReC5HJCzEJYAIPlYnZJBChnkqeBDMpua0HlnKa7W3dY1c4obU_emc21DXUPtwtWlx4Z-uG5B0bfBbZDOd00thna9MHM0NfVY1f0nLV1AE_CcnFSmDnhxeEfk7fFhNnlKXl6nz5P7l8RyAV1ScBgjL9Iq7s5srpQdV6qSuSo5r1QpK2VNIYtxhQKVSDE1qojVEjJmpOCWj8jNPnft2_ceQ6dXLlisa9Ng2wctOJdKplkWyes_5LLtfROX0xJEBqAYixDbQzaeGeJJeu3dyvitZqB3wvVeuI7C9U643gVfHYL7YoXlT8e34QikeyDEr2aO_nfy_6lfZ4iMbw</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Machado, Rodrigo Strehl</creator><creator>Yamamoto, Érica</creator><creator>da Silva Patrício, Francy Reis</creator><creator>Reber, Marialice</creator><creator>Kawakami, Elisabete</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20100501</creationdate><title>Gastric emptying evaluation in children with erosive gastroesophageal reflux disease</title><author>Machado, Rodrigo Strehl ; Yamamoto, Érica ; da Silva Patrício, Francy Reis ; Reber, Marialice ; Kawakami, Elisabete</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-b306e3b2f5791c599c6f9f859d33f9d8f9cab8b6fe7e972e2a9bd8fd041a873c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Breath Tests</topic><topic>Case-Control Studies</topic><topic>Chi-Square Distribution</topic><topic>Child</topic><topic>Endoscopy, Digestive System</topic><topic>Female</topic><topic>Gastric Emptying</topic><topic>Gastroesophageal Reflux - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Statistics, Nonparametric</topic><topic>Surgery</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Machado, Rodrigo Strehl</creatorcontrib><creatorcontrib>Yamamoto, Érica</creatorcontrib><creatorcontrib>da Silva Patrício, Francy Reis</creatorcontrib><creatorcontrib>Reber, Marialice</creatorcontrib><creatorcontrib>Kawakami, Elisabete</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric surgery international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Machado, Rodrigo Strehl</au><au>Yamamoto, Érica</au><au>da Silva Patrício, Francy Reis</au><au>Reber, Marialice</au><au>Kawakami, Elisabete</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastric emptying evaluation in children with erosive gastroesophageal reflux disease</atitle><jtitle>Pediatric surgery international</jtitle><stitle>Pediatr Surg Int</stitle><addtitle>Pediatr Surg Int</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>26</volume><issue>5</issue><spage>473</spage><epage>478</epage><pages>473-478</pages><issn>0179-0358</issn><eissn>1437-9813</eissn><abstract>Background/aims
Delayed gastric emptying may be an important contributing factor to gastroesophageal reflux disease (GERD) in children, but there are limited data on its evaluation in children with erosive-GERD. This study aims to evaluate the gastric emptying of a solid meal in patients with erosive-GERD.
Methods
Nineteen patients (age range 8.79–17.9 years) with erosive esophagitis and 14 healthy controls (age range from 8.04 to 18.7 years) were compared. Esophagitis was graded according to Los Angeles classification. The gastric emptying was evaluated by
13
C-octanoic breath test, which was performed after a 344 kcal standardized solid test meal. Symptoms were evaluated using a standardized questionnaire.
Results
The two most prevalent symptoms were nausea and epigastric pain, which were reported by 12 (63.2%) patients. Irritable bowel syndrome was present in 26.3% (5/19). The median gastric emptying half-time in patients was 160 min (interquartile range [IQR] 140–174 min), which was not different from the controls’ figure (median 157 min, IQR 143–170 min). Additionally, the lag time and the gastric emptying coefficient were not significantly different between the study groups.
Conclusion
Delayed gastric emptying is not associated with erosive esophagitis in children with GERD, when compared to controls.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20405273</pmid><doi>10.1007/s00383-010-2579-4</doi><tpages>6</tpages></addata></record> |
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source | MEDLINE; SpringerLink Journals - AutoHoldings |
subjects | Adolescent Breath Tests Case-Control Studies Chi-Square Distribution Child Endoscopy, Digestive System Female Gastric Emptying Gastroesophageal Reflux - physiopathology Humans Male Medicine Medicine & Public Health Original Article Pediatric Surgery Pediatrics Statistics, Nonparametric Surgery Surveys and Questionnaires |
title | Gastric emptying evaluation in children with erosive gastroesophageal reflux disease |
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