Antiamoebic activity of benzyl glucosinolate from Lepidium virginicum
In a continuation of our search for potential antiprotozoal agents from plants, we found that a crude extract from the roots of Lepidium virginicum exhibited antiprotozoal activity against Entamoeba histolytica trophozoites (IC50 of 100.1 µg/mL). Bioassay‐guided fractionation resulted in the isolati...
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| Veröffentlicht in: | Phytotherapy research 2003-06, Vol.17 (6), p.618-619 |
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| creator | Calzada, Fernando Barbosa, Elizabeth Cedillo-Rivera, Roberto |
| description | In a continuation of our search for potential antiprotozoal agents from plants, we found that a crude extract from the roots of Lepidium virginicum exhibited antiprotozoal activity against Entamoeba histolytica trophozoites (IC50 of 100.1 µg/mL). Bioassay‐guided fractionation resulted in the isolation of one known glucosinolate responsible for such activity. This compound was identified as benzyl glucosinolate. It showed in vitro activity against Entamoeba histolytica strain HM1‐IMSS (IC50 of 20.4 µg/mL). The results support the anecdotal reports for the traditional use of L. virginicum roots in the control of diarrhoea and dysentery in the highlands of Chiapas, Mexico. Copyright © 2003 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.1210 |
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Bioassay‐guided fractionation resulted in the isolation of one known glucosinolate responsible for such activity. This compound was identified as benzyl glucosinolate. It showed in vitro activity against Entamoeba histolytica strain HM1‐IMSS (IC50 of 20.4 µg/mL). The results support the anecdotal reports for the traditional use of L. virginicum roots in the control of diarrhoea and dysentery in the highlands of Chiapas, Mexico. Copyright © 2003 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.1210</identifier><identifier>PMID: 12820228</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; antiamoebic activity ; Antiprotozoal Agents - administration & dosage ; Antiprotozoal Agents - pharmacology ; Antiprotozoal Agents - therapeutic use ; benzyl glucosinolate ; Biological and medical sciences ; Entamoeba histolytica ; Entamoeba histolytica - drug effects ; General pharmacology ; glucosinolate ; Lepidium ; Lepidium virginicum ; Medical sciences ; Parasitic Sensitivity Tests ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Roots ; Thiocyanates - administration & dosage ; Thiocyanates - pharmacology ; Thiocyanates - therapeutic use ; Thioglucosides - administration & dosage ; Thioglucosides - pharmacology ; Thioglucosides - therapeutic use</subject><ispartof>Phytotherapy research, 2003-06, Vol.17 (6), p.618-619</ispartof><rights>Copyright © 2003 John Wiley & Sons, Ltd.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4510-3af18d90753db54a8955f03a6aafb64d4125848dd0807e492237468a612dc1dc3</citedby><cites>FETCH-LOGICAL-c4510-3af18d90753db54a8955f03a6aafb64d4125848dd0807e492237468a612dc1dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.1210$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.1210$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14898169$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12820228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calzada, Fernando</creatorcontrib><creatorcontrib>Barbosa, Elizabeth</creatorcontrib><creatorcontrib>Cedillo-Rivera, Roberto</creatorcontrib><title>Antiamoebic activity of benzyl glucosinolate from Lepidium virginicum</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>In a continuation of our search for potential antiprotozoal agents from plants, we found that a crude extract from the roots of Lepidium virginicum exhibited antiprotozoal activity against Entamoeba histolytica trophozoites (IC50 of 100.1 µg/mL). Bioassay‐guided fractionation resulted in the isolation of one known glucosinolate responsible for such activity. This compound was identified as benzyl glucosinolate. It showed in vitro activity against Entamoeba histolytica strain HM1‐IMSS (IC50 of 20.4 µg/mL). The results support the anecdotal reports for the traditional use of L. virginicum roots in the control of diarrhoea and dysentery in the highlands of Chiapas, Mexico. Copyright © 2003 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>antiamoebic activity</subject><subject>Antiprotozoal Agents - administration & dosage</subject><subject>Antiprotozoal Agents - pharmacology</subject><subject>Antiprotozoal Agents - therapeutic use</subject><subject>benzyl glucosinolate</subject><subject>Biological and medical sciences</subject><subject>Entamoeba histolytica</subject><subject>Entamoeba histolytica - drug effects</subject><subject>General pharmacology</subject><subject>glucosinolate</subject><subject>Lepidium</subject><subject>Lepidium virginicum</subject><subject>Medical sciences</subject><subject>Parasitic Sensitivity Tests</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Roots</subject><subject>Thiocyanates - administration & dosage</subject><subject>Thiocyanates - pharmacology</subject><subject>Thiocyanates - therapeutic use</subject><subject>Thioglucosides - administration & dosage</subject><subject>Thioglucosides - pharmacology</subject><subject>Thioglucosides - therapeutic use</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10EtPGzEUBWALFUGgSP0F1Wyo2Ex6_ZqxlxGCgJSkiNLSneWxPchlHqk9Aw2_nokyalZd3c13z5EOQp8wTDEA-bruwhQTDAdogkHKFPOcfkATkBynDItfx-gkxt8AIAmwI3SMiSBAiJigq1nTeV23rvAm0abzL77bJG2ZFK5521TJU9WbNvqmrXTnkjK0dbJwa299XycvPjz5xpu-_ogOS11FdzbeU_Tj-urh8iZdfJvfXs4WqWEcQ0p1iYWVkHNqC860kJyXQHWmdVlkzDJMuGDCWhCQOyYJoTnLhM4wsQZbQ0_Rl13uOrR_ehc7VftoXFXpxrV9VDmlQg4vA7zYQRPaGIMr1Tr4WoeNwqC2k6lhMrWdbKCfx8y-qJ3dw3GjAZyPQEejqzLoxvi4d0xIgTM5uHTnXn3lNv8tVHcP92Px6H3s3N9_XodnleU05-pxNVfffy6vl5TM1Yq-A65tkO8</recordid><startdate>200306</startdate><enddate>200306</enddate><creator>Calzada, Fernando</creator><creator>Barbosa, Elizabeth</creator><creator>Cedillo-Rivera, Roberto</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200306</creationdate><title>Antiamoebic activity of benzyl glucosinolate from Lepidium virginicum</title><author>Calzada, Fernando ; Barbosa, Elizabeth ; Cedillo-Rivera, Roberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4510-3af18d90753db54a8955f03a6aafb64d4125848dd0807e492237468a612dc1dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>antiamoebic activity</topic><topic>Antiprotozoal Agents - administration & dosage</topic><topic>Antiprotozoal Agents - pharmacology</topic><topic>Antiprotozoal Agents - therapeutic use</topic><topic>benzyl glucosinolate</topic><topic>Biological and medical sciences</topic><topic>Entamoeba histolytica</topic><topic>Entamoeba histolytica - drug effects</topic><topic>General pharmacology</topic><topic>glucosinolate</topic><topic>Lepidium</topic><topic>Lepidium virginicum</topic><topic>Medical sciences</topic><topic>Parasitic Sensitivity Tests</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Roots</topic><topic>Thiocyanates - administration & dosage</topic><topic>Thiocyanates - pharmacology</topic><topic>Thiocyanates - therapeutic use</topic><topic>Thioglucosides - administration & dosage</topic><topic>Thioglucosides - pharmacology</topic><topic>Thioglucosides - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calzada, Fernando</creatorcontrib><creatorcontrib>Barbosa, Elizabeth</creatorcontrib><creatorcontrib>Cedillo-Rivera, Roberto</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calzada, Fernando</au><au>Barbosa, Elizabeth</au><au>Cedillo-Rivera, Roberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiamoebic activity of benzyl glucosinolate from Lepidium virginicum</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. 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Copyright © 2003 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>12820228</pmid><doi>10.1002/ptr.1210</doi><tpages>2</tpages></addata></record> |
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| subjects | Animals antiamoebic activity Antiprotozoal Agents - administration & dosage Antiprotozoal Agents - pharmacology Antiprotozoal Agents - therapeutic use benzyl glucosinolate Biological and medical sciences Entamoeba histolytica Entamoeba histolytica - drug effects General pharmacology glucosinolate Lepidium Lepidium virginicum Medical sciences Parasitic Sensitivity Tests Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Roots Thiocyanates - administration & dosage Thiocyanates - pharmacology Thiocyanates - therapeutic use Thioglucosides - administration & dosage Thioglucosides - pharmacology Thioglucosides - therapeutic use |
| title | Antiamoebic activity of benzyl glucosinolate from Lepidium virginicum |
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