Intratympanic methylprednisolone injections for subjective tinnitus
This study aimed to determine whether intratympanically injected methylprednisolone is effective in treating subjective tinnitus refractory to medical treatment. Prospective, randomised, placebo-controlled, single-blinded study. Seventy adult patients with subjective tinnitus of cochlear origin were...
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| Veröffentlicht in: | Journal of laryngology and otology 2009-11, Vol.123 (11), p.1221-1225 |
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| container_title | Journal of laryngology and otology |
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| creator | Topak, M Sahin-Yilmaz, A Ozdoganoglu, T Yilmaz, H B Ozbay, M Kulekci, M |
| description | This study aimed to determine whether intratympanically injected methylprednisolone is effective in treating subjective tinnitus refractory to medical treatment.
Prospective, randomised, placebo-controlled, single-blinded study.
Seventy adult patients with subjective tinnitus of cochlear origin were randomly assigned to receive intratympanic injection of either methylprednisolone or saline solution. The treatment protocol comprised three intratympanic injections, one per week for three weeks. Improvement in tinnitus severity was measured by a self-rated tinnitus loudness scale and by the tinnitus severity index, at baseline and two weeks after the last injection.
Data for 59 patients were available for analysis. There was no significant difference between the two treatment groups regarding age, sex, pure tone average, pretreatment tinnitus intensity, tinnitus laterality or tinnitus duration. There was a significant post-treatment improvement in self-rated tinnitus loudness scale results in both groups. No significant post-treatment changes in the tinnitus severity index individual and total scores were observed in either group. The most frequently encountered side effects were pain during injection, vertigo, a burning sensation around the ear and in the throat, and a bitter taste. A burning sensation and bitter taste were observed more often in the methylprednisolone group compared with the placebo group.
The results of this study indicate that intratympanic methylprednisolone has no benefit, compared with placebo, for the treatment of subjective tinnitus of cochlear origin refractory to medical treatment. |
| doi_str_mv | 10.1017/S0022215109990685 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733896745</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0022215109990685</cupid><sourcerecordid>733896745</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-69300562de55787f989ae52ce86b08585b1085b34d9727e4d4f51b47167f81433</originalsourceid><addsrcrecordid>eNp1kE2r1DAYhYMo3nH0B7iRIoir6pvvZCmDzlwYEVHRXUjbVDO26Zik4vx7M065FxRXL-E853ByEHqM4QUGLF9-ACCEYI5Baw1C8TtohSVTNWcC7qLVWa7P-hV6kNIBoJiA3EdXWAsGFPMV2lyHHG0-jUcbfFuNLn87DcfouuDTNEzBVT4cXJv9FFLVT7FKc_Pn_dNV2Yfg85weonu9HZJ7tNw1-vTm9cfNrt6_215vXu3rllGda6EpABekc5xLJXuttHWctE6JBhRXvMHlNJR1WhLpWMd6jhsmsZC9wozSNXp-yT3G6cfsUjajT60bBhvcNCcjKVVaSMYL-fQv8jDNMZRyhpR9BPCSt0b4ArVxSim63hyjH208GQzmvK_5Z9_iebIEz83oulvHMmgBni2ATa0d-mhD69MNRwhIYFIXrr5wPmX360a38bsRkkpuxPa9kZ-3X8hu_9bsCk-XsnZsou--utsv_b_ubyKUn0Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>274860514</pqid></control><display><type>article</type><title>Intratympanic methylprednisolone injections for subjective tinnitus</title><source>MEDLINE</source><source>Cambridge University Press Journals Complete</source><creator>Topak, M ; Sahin-Yilmaz, A ; Ozdoganoglu, T ; Yilmaz, H B ; Ozbay, M ; Kulekci, M</creator><creatorcontrib>Topak, M ; Sahin-Yilmaz, A ; Ozdoganoglu, T ; Yilmaz, H B ; Ozbay, M ; Kulekci, M</creatorcontrib><description>This study aimed to determine whether intratympanically injected methylprednisolone is effective in treating subjective tinnitus refractory to medical treatment.
Prospective, randomised, placebo-controlled, single-blinded study.
Seventy adult patients with subjective tinnitus of cochlear origin were randomly assigned to receive intratympanic injection of either methylprednisolone or saline solution. The treatment protocol comprised three intratympanic injections, one per week for three weeks. Improvement in tinnitus severity was measured by a self-rated tinnitus loudness scale and by the tinnitus severity index, at baseline and two weeks after the last injection.
Data for 59 patients were available for analysis. There was no significant difference between the two treatment groups regarding age, sex, pure tone average, pretreatment tinnitus intensity, tinnitus laterality or tinnitus duration. There was a significant post-treatment improvement in self-rated tinnitus loudness scale results in both groups. No significant post-treatment changes in the tinnitus severity index individual and total scores were observed in either group. The most frequently encountered side effects were pain during injection, vertigo, a burning sensation around the ear and in the throat, and a bitter taste. A burning sensation and bitter taste were observed more often in the methylprednisolone group compared with the placebo group.
The results of this study indicate that intratympanic methylprednisolone has no benefit, compared with placebo, for the treatment of subjective tinnitus of cochlear origin refractory to medical treatment.</description><identifier>ISSN: 0022-2151</identifier><identifier>EISSN: 1748-5460</identifier><identifier>DOI: 10.1017/S0022215109990685</identifier><identifier>PMID: 19640315</identifier><identifier>CODEN: JLOTAX</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Audiometry ; Audiometry, Pure-Tone ; Biological and medical sciences ; Drug Administration Schedule ; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology ; Female ; Glucocorticoids - administration & dosage ; Hearing loss ; Humans ; Injections - methods ; Male ; Medical sciences ; Methylprednisolone ; Methylprednisolone - administration & dosage ; Methylprednisolone - adverse effects ; Middle Aged ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Patients ; Pharmacokinetics ; Prospective Studies ; Questionnaires ; Single-Blind Method ; Statistical analysis ; Steroids ; Tinnitus ; Tinnitus - drug therapy ; Treatment Outcome</subject><ispartof>Journal of laryngology and otology, 2009-11, Vol.123 (11), p.1221-1225</ispartof><rights>Copyright © JLO (1984) Limited 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-69300562de55787f989ae52ce86b08585b1085b34d9727e4d4f51b47167f81433</citedby><cites>FETCH-LOGICAL-c439t-69300562de55787f989ae52ce86b08585b1085b34d9727e4d4f51b47167f81433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0022215109990685/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22070479$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19640315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Topak, M</creatorcontrib><creatorcontrib>Sahin-Yilmaz, A</creatorcontrib><creatorcontrib>Ozdoganoglu, T</creatorcontrib><creatorcontrib>Yilmaz, H B</creatorcontrib><creatorcontrib>Ozbay, M</creatorcontrib><creatorcontrib>Kulekci, M</creatorcontrib><title>Intratympanic methylprednisolone injections for subjective tinnitus</title><title>Journal of laryngology and otology</title><addtitle>J. Laryngol. Otol</addtitle><description>This study aimed to determine whether intratympanically injected methylprednisolone is effective in treating subjective tinnitus refractory to medical treatment.
Prospective, randomised, placebo-controlled, single-blinded study.
Seventy adult patients with subjective tinnitus of cochlear origin were randomly assigned to receive intratympanic injection of either methylprednisolone or saline solution. The treatment protocol comprised three intratympanic injections, one per week for three weeks. Improvement in tinnitus severity was measured by a self-rated tinnitus loudness scale and by the tinnitus severity index, at baseline and two weeks after the last injection.
Data for 59 patients were available for analysis. There was no significant difference between the two treatment groups regarding age, sex, pure tone average, pretreatment tinnitus intensity, tinnitus laterality or tinnitus duration. There was a significant post-treatment improvement in self-rated tinnitus loudness scale results in both groups. No significant post-treatment changes in the tinnitus severity index individual and total scores were observed in either group. The most frequently encountered side effects were pain during injection, vertigo, a burning sensation around the ear and in the throat, and a bitter taste. A burning sensation and bitter taste were observed more often in the methylprednisolone group compared with the placebo group.
The results of this study indicate that intratympanic methylprednisolone has no benefit, compared with placebo, for the treatment of subjective tinnitus of cochlear origin refractory to medical treatment.</description><subject>Audiometry</subject><subject>Audiometry, Pure-Tone</subject><subject>Biological and medical sciences</subject><subject>Drug Administration Schedule</subject><subject>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</subject><subject>Female</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Hearing loss</subject><subject>Humans</subject><subject>Injections - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methylprednisolone</subject><subject>Methylprednisolone - administration & dosage</subject><subject>Methylprednisolone - adverse effects</subject><subject>Middle Aged</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Patients</subject><subject>Pharmacokinetics</subject><subject>Prospective Studies</subject><subject>Questionnaires</subject><subject>Single-Blind Method</subject><subject>Statistical analysis</subject><subject>Steroids</subject><subject>Tinnitus</subject><subject>Tinnitus - drug therapy</subject><subject>Treatment Outcome</subject><issn>0022-2151</issn><issn>1748-5460</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE2r1DAYhYMo3nH0B7iRIoir6pvvZCmDzlwYEVHRXUjbVDO26Zik4vx7M065FxRXL-E853ByEHqM4QUGLF9-ACCEYI5Baw1C8TtohSVTNWcC7qLVWa7P-hV6kNIBoJiA3EdXWAsGFPMV2lyHHG0-jUcbfFuNLn87DcfouuDTNEzBVT4cXJv9FFLVT7FKc_Pn_dNV2Yfg85weonu9HZJ7tNw1-vTm9cfNrt6_215vXu3rllGda6EpABekc5xLJXuttHWctE6JBhRXvMHlNJR1WhLpWMd6jhsmsZC9wozSNXp-yT3G6cfsUjajT60bBhvcNCcjKVVaSMYL-fQv8jDNMZRyhpR9BPCSt0b4ArVxSim63hyjH208GQzmvK_5Z9_iebIEz83oulvHMmgBni2ATa0d-mhD69MNRwhIYFIXrr5wPmX360a38bsRkkpuxPa9kZ-3X8hu_9bsCk-XsnZsou--utsv_b_ubyKUn0Q</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Topak, M</creator><creator>Sahin-Yilmaz, A</creator><creator>Ozdoganoglu, T</creator><creator>Yilmaz, H B</creator><creator>Ozbay, M</creator><creator>Kulekci, M</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Intratympanic methylprednisolone injections for subjective tinnitus</title><author>Topak, M ; Sahin-Yilmaz, A ; Ozdoganoglu, T ; Yilmaz, H B ; Ozbay, M ; Kulekci, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-69300562de55787f989ae52ce86b08585b1085b34d9727e4d4f51b47167f81433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Audiometry</topic><topic>Audiometry, Pure-Tone</topic><topic>Biological and medical sciences</topic><topic>Drug Administration Schedule</topic><topic>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</topic><topic>Female</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Hearing loss</topic><topic>Humans</topic><topic>Injections - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methylprednisolone</topic><topic>Methylprednisolone - administration & dosage</topic><topic>Methylprednisolone - adverse effects</topic><topic>Middle Aged</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Patients</topic><topic>Pharmacokinetics</topic><topic>Prospective Studies</topic><topic>Questionnaires</topic><topic>Single-Blind Method</topic><topic>Statistical analysis</topic><topic>Steroids</topic><topic>Tinnitus</topic><topic>Tinnitus - drug therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Topak, M</creatorcontrib><creatorcontrib>Sahin-Yilmaz, A</creatorcontrib><creatorcontrib>Ozdoganoglu, T</creatorcontrib><creatorcontrib>Yilmaz, H B</creatorcontrib><creatorcontrib>Ozbay, M</creatorcontrib><creatorcontrib>Kulekci, M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of laryngology and otology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Topak, M</au><au>Sahin-Yilmaz, A</au><au>Ozdoganoglu, T</au><au>Yilmaz, H B</au><au>Ozbay, M</au><au>Kulekci, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intratympanic methylprednisolone injections for subjective tinnitus</atitle><jtitle>Journal of laryngology and otology</jtitle><addtitle>J. Laryngol. Otol</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>123</volume><issue>11</issue><spage>1221</spage><epage>1225</epage><pages>1221-1225</pages><issn>0022-2151</issn><eissn>1748-5460</eissn><coden>JLOTAX</coden><abstract>This study aimed to determine whether intratympanically injected methylprednisolone is effective in treating subjective tinnitus refractory to medical treatment.
Prospective, randomised, placebo-controlled, single-blinded study.
Seventy adult patients with subjective tinnitus of cochlear origin were randomly assigned to receive intratympanic injection of either methylprednisolone or saline solution. The treatment protocol comprised three intratympanic injections, one per week for three weeks. Improvement in tinnitus severity was measured by a self-rated tinnitus loudness scale and by the tinnitus severity index, at baseline and two weeks after the last injection.
Data for 59 patients were available for analysis. There was no significant difference between the two treatment groups regarding age, sex, pure tone average, pretreatment tinnitus intensity, tinnitus laterality or tinnitus duration. There was a significant post-treatment improvement in self-rated tinnitus loudness scale results in both groups. No significant post-treatment changes in the tinnitus severity index individual and total scores were observed in either group. The most frequently encountered side effects were pain during injection, vertigo, a burning sensation around the ear and in the throat, and a bitter taste. A burning sensation and bitter taste were observed more often in the methylprednisolone group compared with the placebo group.
The results of this study indicate that intratympanic methylprednisolone has no benefit, compared with placebo, for the treatment of subjective tinnitus of cochlear origin refractory to medical treatment.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>19640315</pmid><doi>10.1017/S0022215109990685</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0022-2151 |
| ispartof | Journal of laryngology and otology, 2009-11, Vol.123 (11), p.1221-1225 |
| issn | 0022-2151 1748-5460 |
| language | eng |
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| subjects | Audiometry Audiometry, Pure-Tone Biological and medical sciences Drug Administration Schedule Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Female Glucocorticoids - administration & dosage Hearing loss Humans Injections - methods Male Medical sciences Methylprednisolone Methylprednisolone - administration & dosage Methylprednisolone - adverse effects Middle Aged Non tumoral diseases Otorhinolaryngology. Stomatology Patients Pharmacokinetics Prospective Studies Questionnaires Single-Blind Method Statistical analysis Steroids Tinnitus Tinnitus - drug therapy Treatment Outcome |
| title | Intratympanic methylprednisolone injections for subjective tinnitus |
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