The comparative antimalarial properties of weak base and neutral synthetic ozonides

Thirty-three N-acyl 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. For these ozonides, weak base functional groups were not required for high antimalarial potency against Plasmodium falciparum in vitro, but were necessary for high antimalarial efficacy in Plasmodium berghei-infecte...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-01, Vol.20 (2), p.563-566
Hauptverfasser:	Tang, Yuanqing, Wittlin, Sergio, Charman, Susan A., Chollet, Jacques, Chiu, Francis C.K., Morizzi, Julia, Johnson, Lisa M., Tomas, Josefina Santo, Scheurer, Christian, Snyder, Chistopher, Zhou, Lin, Dong, Yuxiang, Charman, William N., Matile, Hugues, Urwyler, Heinrich, Dorn, Arnulf, Vennerstrom, Jonathan L.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,4-Trioxolanes Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarial Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacokinetics Antiparasitic agents Artemisinin Biological and medical sciences Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Heterocyclic Compounds - pharmacokinetics Medical sciences Mice Peroxides Pharmacology. Drug treatments Plasmodium falciparum Plasmodium falciparum - drug effects Rats Secondary ozonides
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!