Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation

Platelet activation is a complex balance of positive and negative signaling pathways. The protein kinase C (PKC) family is a major regulator of platelet granule secretion, integrin activation, aggregation, spreading and procoagulant activity. As broad‐spectrum PKC inhibitors reduce secretion and agg...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2010-03, Vol.8 (3), p.454-462
Hauptverfasser:	HARPER, M. T., POOLE, A. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	aggregation Animals Blood Platelets - enzymology Cytoplasmic Granules - enzymology Enzyme Activation Humans Isoenzymes Mice Mice, Knockout Platelet Activation - genetics Platelet Aggregation protein kinase Protein Kinase C - genetics Protein Kinase C - metabolism protein kinase C secretion Signal Transduction thrombosis Thrombosis - blood Thrombosis - enzymology Thrombosis - genetics thromboxane generation Thromboxanes - metabolism
Online-Zugang:	Volltext
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