Chemical characterization of lycium barbarum polysaccharides and its inhibition against liver oxidative injury of high-fat mice
In this study, we investigated chemical structure of lycium barbarum polysaccharides and its modulatory effect on oxidative stress in high-fat mice. The polysaccharides mainly contained xylose and glucose. Little amount of rhamnose, mannose and galactose was observed. The lycium barbarum polysacchar...
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| Veröffentlicht in: | International journal of biological macromolecules 2010-06, Vol.46 (5), p.540-543 |
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| creator | Wu, Hua-Tao He, Xue-Jun Hong, Ying-Kai Ma, Tao Xu, Yan-Ping Li, Hui-Hua |
| description | In this study, we investigated chemical structure of lycium barbarum polysaccharides and its modulatory effect on oxidative stress in high-fat mice. The polysaccharides mainly contained xylose and glucose. Little amount of rhamnose, mannose and galactose was observed. The lycium barbarum polysaccharides had IR bands at 800–1200
cm
−1, 1450–1800
cm
−1, 2500–3000
cm
−1, and 3200–3600
cm
−1, which were distinctive absorptions of polysaccharides. Rats are fed with high-fat diet for 2 months. Results showed that blood and liver antioxidant enzymes activities and GSH level in model mice significantly decreased, and MDA level significantly increased (
P
<
0.01) compared to normal control mice. Administration of lycium barbarum polysaccharides significantly increased antioxidant enzymes activities and decreased MDA level in mice (
P
<
0.01) compared to model group. |
| doi_str_mv | 10.1016/j.ijbiomac.2010.02.010 |
| format | Article |
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cm
−1, 1450–1800
cm
−1, 2500–3000
cm
−1, and 3200–3600
cm
−1, which were distinctive absorptions of polysaccharides. Rats are fed with high-fat diet for 2 months. Results showed that blood and liver antioxidant enzymes activities and GSH level in model mice significantly decreased, and MDA level significantly increased (
P
<
0.01) compared to normal control mice. Administration of lycium barbarum polysaccharides significantly increased antioxidant enzymes activities and decreased MDA level in mice (
P
<
0.01) compared to model group.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2010.02.010</identifier><identifier>PMID: 20193709</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antioxidants - metabolism ; Dietary Fats - pharmacology ; Drugs, Chinese Herbal - chemistry ; Drugs, Chinese Herbal - pharmacology ; FT-IR ; GC–MS ; Glutathione - blood ; High-fat diet ; Liver - drug effects ; Liver - enzymology ; Liver - metabolism ; Lycium barbarum polysaccharides ; Malondialdehyde - blood ; Mice ; Nitric Oxide - blood ; Oxidative Stress - drug effects ; Phytotherapy ; Rats ; Spectroscopy, Fourier Transform Infrared</subject><ispartof>International journal of biological macromolecules, 2010-06, Vol.46 (5), p.540-543</ispartof><rights>2010 Elsevier B.V.</rights><rights>Copyright 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-91653af0e3451f777c02b9738789e34fa4d693f97f500659a94db0d58033265f3</citedby><cites>FETCH-LOGICAL-c367t-91653af0e3451f777c02b9738789e34fa4d693f97f500659a94db0d58033265f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0141813010000607$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20193709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Hua-Tao</creatorcontrib><creatorcontrib>He, Xue-Jun</creatorcontrib><creatorcontrib>Hong, Ying-Kai</creatorcontrib><creatorcontrib>Ma, Tao</creatorcontrib><creatorcontrib>Xu, Yan-Ping</creatorcontrib><creatorcontrib>Li, Hui-Hua</creatorcontrib><title>Chemical characterization of lycium barbarum polysaccharides and its inhibition against liver oxidative injury of high-fat mice</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>In this study, we investigated chemical structure of lycium barbarum polysaccharides and its modulatory effect on oxidative stress in high-fat mice. The polysaccharides mainly contained xylose and glucose. Little amount of rhamnose, mannose and galactose was observed. The lycium barbarum polysaccharides had IR bands at 800–1200
cm
−1, 1450–1800
cm
−1, 2500–3000
cm
−1, and 3200–3600
cm
−1, which were distinctive absorptions of polysaccharides. Rats are fed with high-fat diet for 2 months. Results showed that blood and liver antioxidant enzymes activities and GSH level in model mice significantly decreased, and MDA level significantly increased (
P
<
0.01) compared to normal control mice. Administration of lycium barbarum polysaccharides significantly increased antioxidant enzymes activities and decreased MDA level in mice (
P
<
0.01) compared to model group.</description><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Dietary Fats - pharmacology</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>FT-IR</subject><subject>GC–MS</subject><subject>Glutathione - blood</subject><subject>High-fat diet</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver - metabolism</subject><subject>Lycium barbarum polysaccharides</subject><subject>Malondialdehyde - blood</subject><subject>Mice</subject><subject>Nitric Oxide - blood</subject><subject>Oxidative Stress - drug effects</subject><subject>Phytotherapy</subject><subject>Rats</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUE1v1DAUtBCILoW_UPnGKVs7TuL4BlpRQKrEBc6WYz83L0rixU5WbC_8dRy25YpkaazRfOgNITec7Tnjze2wx6HDMBm7L1kmWbnP8ILseCtVwRgTL8mO8YoXLRfsirxJachsU_P2NbnKFiUkUzvy-9DDhNaM1PYmGrtAxEezYJhp8HQ8W1wn2pmYX_4cw3hOxm5SdJComR3FJVGce-zwr8s8GJzTQkc8QaThF7qcdoIsGdZ43kJ7fOgLbxaae-EteeXNmODdE16TH3efvh--FPffPn89fLwvrGjkUije1MJ4BqKquZdSWlZ2SopWtipz3lSuUcIr6evtSGVU5Trm6pYJUTa1F9fk_SX3GMPPFdKiJ0wWxtHMENakpRCtqrhssrK5KG0MKUXw-hhxMvGsOdPb9nrQz9vrbXvNSp0hG2-eKtZuAvfP9jx2Fny4CCAfekKIOlmE2YLDCHbRLuD_Ov4ATzKaSw</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Wu, Hua-Tao</creator><creator>He, Xue-Jun</creator><creator>Hong, Ying-Kai</creator><creator>Ma, Tao</creator><creator>Xu, Yan-Ping</creator><creator>Li, Hui-Hua</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100601</creationdate><title>Chemical characterization of lycium barbarum polysaccharides and its inhibition against liver oxidative injury of high-fat mice</title><author>Wu, Hua-Tao ; He, Xue-Jun ; Hong, Ying-Kai ; Ma, Tao ; Xu, Yan-Ping ; Li, Hui-Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-91653af0e3451f777c02b9738789e34fa4d693f97f500659a94db0d58033265f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Dietary Fats - pharmacology</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>FT-IR</topic><topic>GC–MS</topic><topic>Glutathione - blood</topic><topic>High-fat diet</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver - metabolism</topic><topic>Lycium barbarum polysaccharides</topic><topic>Malondialdehyde - blood</topic><topic>Mice</topic><topic>Nitric Oxide - blood</topic><topic>Oxidative Stress - drug effects</topic><topic>Phytotherapy</topic><topic>Rats</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Hua-Tao</creatorcontrib><creatorcontrib>He, Xue-Jun</creatorcontrib><creatorcontrib>Hong, Ying-Kai</creatorcontrib><creatorcontrib>Ma, Tao</creatorcontrib><creatorcontrib>Xu, Yan-Ping</creatorcontrib><creatorcontrib>Li, Hui-Hua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Hua-Tao</au><au>He, Xue-Jun</au><au>Hong, Ying-Kai</au><au>Ma, Tao</au><au>Xu, Yan-Ping</au><au>Li, Hui-Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical characterization of lycium barbarum polysaccharides and its inhibition against liver oxidative injury of high-fat mice</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>46</volume><issue>5</issue><spage>540</spage><epage>543</epage><pages>540-543</pages><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>In this study, we investigated chemical structure of lycium barbarum polysaccharides and its modulatory effect on oxidative stress in high-fat mice. The polysaccharides mainly contained xylose and glucose. Little amount of rhamnose, mannose and galactose was observed. The lycium barbarum polysaccharides had IR bands at 800–1200
cm
−1, 1450–1800
cm
−1, 2500–3000
cm
−1, and 3200–3600
cm
−1, which were distinctive absorptions of polysaccharides. Rats are fed with high-fat diet for 2 months. Results showed that blood and liver antioxidant enzymes activities and GSH level in model mice significantly decreased, and MDA level significantly increased (
P
<
0.01) compared to normal control mice. Administration of lycium barbarum polysaccharides significantly increased antioxidant enzymes activities and decreased MDA level in mice (
P
<
0.01) compared to model group.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>20193709</pmid><doi>10.1016/j.ijbiomac.2010.02.010</doi><tpages>4</tpages></addata></record> |
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| issn | 0141-8130 1879-0003 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antioxidants - metabolism Dietary Fats - pharmacology Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology FT-IR GC–MS Glutathione - blood High-fat diet Liver - drug effects Liver - enzymology Liver - metabolism Lycium barbarum polysaccharides Malondialdehyde - blood Mice Nitric Oxide - blood Oxidative Stress - drug effects Phytotherapy Rats Spectroscopy, Fourier Transform Infrared |
| title | Chemical characterization of lycium barbarum polysaccharides and its inhibition against liver oxidative injury of high-fat mice |
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