Effect of recombinant basic fibroblast growth factor on reimplanted teeth in beagle dogs
Objectives This study assessed the effect of recombinant fibroblast growth factor (FGF-2) on reimplanted teeth. Study design Premolars were reimplanted in dogs. Roots on the left side of the mandible were treated with FGF-2, whereas roots on right side served as controls. At 2, 4, or 8 weeks after t...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2010, Vol.109 (1), p.142-148 |
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| container_title | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics |
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| creator | Seshima, Fumi, DDS Ota, Mikio, DDS, PhD Kinumatsu, Takashi, DDS, PhD Shibukawa, Yoshihiro, DDS, PhD Yamada, Satoru, DDS, PhD |
| description | Objectives This study assessed the effect of recombinant fibroblast growth factor (FGF-2) on reimplanted teeth. Study design Premolars were reimplanted in dogs. Roots on the left side of the mandible were treated with FGF-2, whereas roots on right side served as controls. At 2, 4, or 8 weeks after treatment, animals were humanely killed and specimens collected and processed for histopathologic examination. Results After 2 weeks, proliferating cell nuclear antigen-positive cell ratios in the experimental group were significantly greater than those in the control group ( P < .01). After 4 and 8 weeks, the experimental group showed formation of new cementum. Moreover, incidence of replacement resorption in the experimental group was significantly lower than that in the control group ( P < .01). Conclusion The results indicate that FGF-2 promotes formation of new periodontal ligament and prevents ankylosis and root resorption following reimplantation of teeth. |
| doi_str_mv | 10.1016/j.tripleo.2009.07.055 |
| format | Article |
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Study design Premolars were reimplanted in dogs. Roots on the left side of the mandible were treated with FGF-2, whereas roots on right side served as controls. At 2, 4, or 8 weeks after treatment, animals were humanely killed and specimens collected and processed for histopathologic examination. Results After 2 weeks, proliferating cell nuclear antigen-positive cell ratios in the experimental group were significantly greater than those in the control group ( P < .01). After 4 and 8 weeks, the experimental group showed formation of new cementum. Moreover, incidence of replacement resorption in the experimental group was significantly lower than that in the control group ( P < .01). Conclusion The results indicate that FGF-2 promotes formation of new periodontal ligament and prevents ankylosis and root resorption following reimplantation of teeth.</description><identifier>ISSN: 1079-2104</identifier><identifier>EISSN: 1528-395X</identifier><identifier>DOI: 10.1016/j.tripleo.2009.07.055</identifier><identifier>PMID: 19880335</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Animals ; Biological and medical sciences ; Dental Cementum - drug effects ; Dental Cementum - physiology ; Dentistry ; Dogs ; Fibroblast Growth Factor 2 - pharmacology ; Growth Substances - pharmacology ; Immunoenzyme Techniques ; Medical sciences ; Otorhinolaryngology. Stomatology ; Periodontal Ligament - drug effects ; Periodontal Ligament - physiology ; Proliferating Cell Nuclear Antigen - analysis ; Proliferating Cell Nuclear Antigen - biosynthesis ; Recombinant Proteins - pharmacology ; Regeneration - drug effects ; Root Resorption - prevention & control ; Surgery ; Tooth Ankylosis - prevention & control ; Tooth Replantation</subject><ispartof>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2010, Vol.109 (1), p.142-148</ispartof><rights>2010</rights><rights>2015 INIST-CNRS</rights><rights>Crown Copyright 2010. Published by Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-256708b7bf80cf3cd52c2db8da3311f72c0287b984d005c25f2e9b1833d867193</citedby><cites>FETCH-LOGICAL-c515t-256708b7bf80cf3cd52c2db8da3311f72c0287b984d005c25f2e9b1833d867193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1079210409005733$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22272758$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19880335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seshima, Fumi, DDS</creatorcontrib><creatorcontrib>Ota, Mikio, DDS, PhD</creatorcontrib><creatorcontrib>Kinumatsu, Takashi, DDS, PhD</creatorcontrib><creatorcontrib>Shibukawa, Yoshihiro, DDS, PhD</creatorcontrib><creatorcontrib>Yamada, Satoru, DDS, PhD</creatorcontrib><title>Effect of recombinant basic fibroblast growth factor on reimplanted teeth in beagle dogs</title><title>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</title><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><description>Objectives This study assessed the effect of recombinant fibroblast growth factor (FGF-2) on reimplanted teeth. Study design Premolars were reimplanted in dogs. Roots on the left side of the mandible were treated with FGF-2, whereas roots on right side served as controls. At 2, 4, or 8 weeks after treatment, animals were humanely killed and specimens collected and processed for histopathologic examination. Results After 2 weeks, proliferating cell nuclear antigen-positive cell ratios in the experimental group were significantly greater than those in the control group ( P < .01). After 4 and 8 weeks, the experimental group showed formation of new cementum. Moreover, incidence of replacement resorption in the experimental group was significantly lower than that in the control group ( P < .01). Conclusion The results indicate that FGF-2 promotes formation of new periodontal ligament and prevents ankylosis and root resorption following reimplantation of teeth.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dental Cementum - drug effects</subject><subject>Dental Cementum - physiology</subject><subject>Dentistry</subject><subject>Dogs</subject><subject>Fibroblast Growth Factor 2 - pharmacology</subject><subject>Growth Substances - pharmacology</subject><subject>Immunoenzyme Techniques</subject><subject>Medical sciences</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Periodontal Ligament - drug effects</subject><subject>Periodontal Ligament - physiology</subject><subject>Proliferating Cell Nuclear Antigen - analysis</subject><subject>Proliferating Cell Nuclear Antigen - biosynthesis</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Regeneration - drug effects</subject><subject>Root Resorption - prevention & control</subject><subject>Surgery</subject><subject>Tooth Ankylosis - prevention & control</subject><subject>Tooth Replantation</subject><issn>1079-2104</issn><issn>1528-395X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkuLFDEQgBtR3HX1Jyh9EU_dVpLNJLkoy7I-YMGDCnsLeVTGjD2dMcko--9NM42CF08pyFcPvqque05gJEA2r3djzfEwYRopgBpBjMD5g-6ccCoHpvjdwxaDUAMlcHnWPSllBwAbptTj7owoKYExft7d3YSArvYp9Bld2ts4m7n21pTo-hBtTnYypfbbnH7Vb30wrqbcp7nRcX-YGou-r4jtL869RbOdsPdpW552j4KZCj5b34vu67ubL9cfhttP7z9eX90OjhNeB8o3AqQVNkhwgTnPqaPeSm8YIyQI6oBKYZW89ADcUR4oKkskY15uBFHsont1qnvI6ccRS9X7WBxObTRMx6IFY1IxBgvJT6TLqZSMQR9y3Jt8rwnoxane6dWpXpxqELo5bXkv1g5Hu0f_N2uV2ICXK2CKM1PIZnax_OEopYIKLhv39sRh8_EzYtbFRZwd-tjcV-1T_O8ob_6p4KY4x9b0O95j2aVjnptsTXShGvTn5QCW_YNq8poJ9hvMQayX</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Seshima, Fumi, DDS</creator><creator>Ota, Mikio, DDS, PhD</creator><creator>Kinumatsu, Takashi, DDS, PhD</creator><creator>Shibukawa, Yoshihiro, DDS, PhD</creator><creator>Yamada, Satoru, DDS, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Effect of recombinant basic fibroblast growth factor on reimplanted teeth in beagle dogs</title><author>Seshima, Fumi, DDS ; Ota, Mikio, DDS, PhD ; Kinumatsu, Takashi, DDS, PhD ; Shibukawa, Yoshihiro, DDS, PhD ; Yamada, Satoru, DDS, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-256708b7bf80cf3cd52c2db8da3311f72c0287b984d005c25f2e9b1833d867193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dental Cementum - drug effects</topic><topic>Dental Cementum - physiology</topic><topic>Dentistry</topic><topic>Dogs</topic><topic>Fibroblast Growth Factor 2 - pharmacology</topic><topic>Growth Substances - pharmacology</topic><topic>Immunoenzyme Techniques</topic><topic>Medical sciences</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Periodontal Ligament - drug effects</topic><topic>Periodontal Ligament - physiology</topic><topic>Proliferating Cell Nuclear Antigen - analysis</topic><topic>Proliferating Cell Nuclear Antigen - biosynthesis</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Regeneration - drug effects</topic><topic>Root Resorption - prevention & control</topic><topic>Surgery</topic><topic>Tooth Ankylosis - prevention & control</topic><topic>Tooth Replantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seshima, Fumi, DDS</creatorcontrib><creatorcontrib>Ota, Mikio, DDS, PhD</creatorcontrib><creatorcontrib>Kinumatsu, Takashi, DDS, PhD</creatorcontrib><creatorcontrib>Shibukawa, Yoshihiro, DDS, PhD</creatorcontrib><creatorcontrib>Yamada, Satoru, DDS, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seshima, Fumi, DDS</au><au>Ota, Mikio, DDS, PhD</au><au>Kinumatsu, Takashi, DDS, PhD</au><au>Shibukawa, Yoshihiro, DDS, PhD</au><au>Yamada, Satoru, DDS, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of recombinant basic fibroblast growth factor on reimplanted teeth in beagle dogs</atitle><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><date>2010</date><risdate>2010</risdate><volume>109</volume><issue>1</issue><spage>142</spage><epage>148</epage><pages>142-148</pages><issn>1079-2104</issn><eissn>1528-395X</eissn><abstract>Objectives This study assessed the effect of recombinant fibroblast growth factor (FGF-2) on reimplanted teeth. Study design Premolars were reimplanted in dogs. Roots on the left side of the mandible were treated with FGF-2, whereas roots on right side served as controls. At 2, 4, or 8 weeks after treatment, animals were humanely killed and specimens collected and processed for histopathologic examination. Results After 2 weeks, proliferating cell nuclear antigen-positive cell ratios in the experimental group were significantly greater than those in the control group ( P < .01). After 4 and 8 weeks, the experimental group showed formation of new cementum. Moreover, incidence of replacement resorption in the experimental group was significantly lower than that in the control group ( P < .01). Conclusion The results indicate that FGF-2 promotes formation of new periodontal ligament and prevents ankylosis and root resorption following reimplantation of teeth.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>19880335</pmid><doi>10.1016/j.tripleo.2009.07.055</doi><tpages>7</tpages></addata></record> |
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| ispartof | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2010, Vol.109 (1), p.142-148 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Dental Cementum - drug effects Dental Cementum - physiology Dentistry Dogs Fibroblast Growth Factor 2 - pharmacology Growth Substances - pharmacology Immunoenzyme Techniques Medical sciences Otorhinolaryngology. Stomatology Periodontal Ligament - drug effects Periodontal Ligament - physiology Proliferating Cell Nuclear Antigen - analysis Proliferating Cell Nuclear Antigen - biosynthesis Recombinant Proteins - pharmacology Regeneration - drug effects Root Resorption - prevention & control Surgery Tooth Ankylosis - prevention & control Tooth Replantation |
| title | Effect of recombinant basic fibroblast growth factor on reimplanted teeth in beagle dogs |
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