Oxidized Mesoporous Silicon Microparticles for Improved Oral Delivery of Poorly Soluble Drugs

Surface functionalized mesoporous silicon (pSi) microparticles are reported as a solid dispersion carrier for improving dissolution and enhancing the orally administered pharmacokinetics (fasted rat model) of indomethacin (IMC), employed as a model poorly soluble BCS type II drug. IMC was loaded via...

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Veröffentlicht in:	Molecular pharmaceutics 2010-02, Vol.7 (1), p.227-236
Hauptverfasser:	Wang, Feng, Hui, He, Barnes, Timothy J, Barnett, Christian, Prestidge, Clive A
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Administration, Oral Animals Biological Availability Calorimetry, Differential Scanning Drug Delivery Systems In Vitro Techniques Indomethacin - administration & dosage Indomethacin - chemistry Indomethacin - pharmacokinetics Male Microscopy, Electron, Scanning Particle Size Powder Diffraction Rats Rats, Sprague-Dawley Silicon Solubility Spectroscopy, Fourier Transform Infrared Thermogravimetry Water
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