Differential Response of Central Dopaminergic System in Acute and Chronic Unpredictable Stress Models in Rats
We aimed to evaluate the response of dopaminergic system in acute stress (AS) and chronic unpredictable stress (CUS) by measuring dopamine (DA) levels, its receptor densities in the frontal cortex, striatum, hippocampus, amygdala and orbito-frontal cortex regions of rat brain, and investigated the c...
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| Veröffentlicht in: | Neurochemical research 2010-01, Vol.35 (1), p.22-32 |
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| creator | Rasheed, Naila Ahmad, Ausaf Pandey, Chandra Prakash Chaturvedi, Rajnish Kumar Lohani, Mohtashim Palit, Gautam |
| description | We aimed to evaluate the response of dopaminergic system in acute stress (AS) and chronic unpredictable stress (CUS) by measuring dopamine (DA) levels, its receptor densities in the frontal cortex, striatum, hippocampus, amygdala and orbito-frontal cortex regions of rat brain, and investigated the corresponding behavioral locomotor changes. Involvement of D
1
receptor was also examined during AS and CUS using A 68930, a D
1
selective agonist. Rats were exposed to AS (single immobilization for 150 min) and CUS (two different stressors for 7 days). AS significantly decreased the DA levels in the striatum and hippocampus, and A 68930 pretreatment significantly reverted these changes. However, in the frontal cortex significantly increased DA levels were remain unchanged following A 68930. CUS led to a decrease of DA levels in the frontal cortex, striatum and hippocampus, which were normalized by A 68930. Saturation radioligand binding assays revealed a significant decrease in the number of D
1
-like receptors in the frontal cortex during CUS, which were further decreased by A 68930 pretreatment. However, in the striatum and hippocampus, A 68930 pretreatment reduced the CUS induced increase in the number of D
1
-like receptors. No significant changes were observed in the amygdala and orbito-frontal cortex during AS and CUS, while D
2
-like receptors were unchanged in all the brain regions studied. Locomotor activity was significantly decreased in both the stress models, A 68930 pretreatment significantly increased stereotypic counts and horizontal activity. Thus, present investigation provide insights into the differential regional response of dopaminergic system during AS and CUS. Further, neurochemical and behavioral effects of D
1
agonist pretreatment suggest specific modulatory role of D
1
receptor under such stressful episodes. |
| doi_str_mv | 10.1007/s11064-009-0026-5 |
| format | Article |
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1
receptor was also examined during AS and CUS using A 68930, a D
1
selective agonist. Rats were exposed to AS (single immobilization for 150 min) and CUS (two different stressors for 7 days). AS significantly decreased the DA levels in the striatum and hippocampus, and A 68930 pretreatment significantly reverted these changes. However, in the frontal cortex significantly increased DA levels were remain unchanged following A 68930. CUS led to a decrease of DA levels in the frontal cortex, striatum and hippocampus, which were normalized by A 68930. Saturation radioligand binding assays revealed a significant decrease in the number of D
1
-like receptors in the frontal cortex during CUS, which were further decreased by A 68930 pretreatment. However, in the striatum and hippocampus, A 68930 pretreatment reduced the CUS induced increase in the number of D
1
-like receptors. No significant changes were observed in the amygdala and orbito-frontal cortex during AS and CUS, while D
2
-like receptors were unchanged in all the brain regions studied. Locomotor activity was significantly decreased in both the stress models, A 68930 pretreatment significantly increased stereotypic counts and horizontal activity. Thus, present investigation provide insights into the differential regional response of dopaminergic system during AS and CUS. Further, neurochemical and behavioral effects of D
1
agonist pretreatment suggest specific modulatory role of D
1
receptor under such stressful episodes.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-009-0026-5</identifier><identifier>PMID: 19568932</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Acute Disease ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Chromatography, High Pressure Liquid ; Chronic Disease ; Disease Models, Animal ; Dopamine - metabolism ; Locomotion ; Male ; Neurochemistry ; Neurology ; Neurosciences ; Original Paper ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine - metabolism ; Stress, Physiological</subject><ispartof>Neurochemical research, 2010-01, Vol.35 (1), p.22-32</ispartof><rights>Springer Science+Business Media, LLC 2009</rights><rights>Springer Science+Business Media, LLC 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-df0c612ea62ec51fe15e5b6acdd044436dfd49d1e68ebe6d1c79056fafe55c0e3</citedby><cites>FETCH-LOGICAL-c467t-df0c612ea62ec51fe15e5b6acdd044436dfd49d1e68ebe6d1c79056fafe55c0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-009-0026-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-009-0026-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19568932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rasheed, Naila</creatorcontrib><creatorcontrib>Ahmad, Ausaf</creatorcontrib><creatorcontrib>Pandey, Chandra Prakash</creatorcontrib><creatorcontrib>Chaturvedi, Rajnish Kumar</creatorcontrib><creatorcontrib>Lohani, Mohtashim</creatorcontrib><creatorcontrib>Palit, Gautam</creatorcontrib><title>Differential Response of Central Dopaminergic System in Acute and Chronic Unpredictable Stress Models in Rats</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><addtitle>Neurochem Res</addtitle><description>We aimed to evaluate the response of dopaminergic system in acute stress (AS) and chronic unpredictable stress (CUS) by measuring dopamine (DA) levels, its receptor densities in the frontal cortex, striatum, hippocampus, amygdala and orbito-frontal cortex regions of rat brain, and investigated the corresponding behavioral locomotor changes. Involvement of D
1
receptor was also examined during AS and CUS using A 68930, a D
1
selective agonist. Rats were exposed to AS (single immobilization for 150 min) and CUS (two different stressors for 7 days). AS significantly decreased the DA levels in the striatum and hippocampus, and A 68930 pretreatment significantly reverted these changes. However, in the frontal cortex significantly increased DA levels were remain unchanged following A 68930. CUS led to a decrease of DA levels in the frontal cortex, striatum and hippocampus, which were normalized by A 68930. Saturation radioligand binding assays revealed a significant decrease in the number of D
1
-like receptors in the frontal cortex during CUS, which were further decreased by A 68930 pretreatment. However, in the striatum and hippocampus, A 68930 pretreatment reduced the CUS induced increase in the number of D
1
-like receptors. No significant changes were observed in the amygdala and orbito-frontal cortex during AS and CUS, while D
2
-like receptors were unchanged in all the brain regions studied. Locomotor activity was significantly decreased in both the stress models, A 68930 pretreatment significantly increased stereotypic counts and horizontal activity. Thus, present investigation provide insights into the differential regional response of dopaminergic system during AS and CUS. Further, neurochemical and behavioral effects of D
1
agonist pretreatment suggest specific modulatory role of D
1
receptor under such stressful episodes.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Chronic Disease</subject><subject>Disease Models, Animal</subject><subject>Dopamine - metabolism</subject><subject>Locomotion</subject><subject>Male</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Dopamine - metabolism</subject><subject>Stress, Physiological</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU9rFTEUxYMo9vXpB3AjwYWuRvNnkpksy6tWoSK0dh3ykps6ZSYZc2cW_fbm8R4UBF1cLtzzOyeEQ8gbzj5yxrpPyDnTbcOYqSN0o56RDVedbLRh8jnZMFlVyQ07I-eID4xVl-AvyRk3SvdGig2ZLocYoUBaBjfSG8A5JwSaI93VW6m3yzy7aUhQ7gdPbx9xgYkOiV74dQHqUqC7XyWnqt2luUAY_OL2I9DbpQAi_Z4DjHgw3LgFX5EX0Y0Ir097S-6-fP65-9pc_7j6tru4bnyru6UJkXnNBTgtwCsegStQe-18CKxtW6lDDK0JHHQPe9CB-84wpaOLoJRnILfkwzF3Lvn3CrjYaUAP4-gS5BVtJ2VvhBG6ku__SwoulBGV35J3f4EPeS2p_sIKwXvRd31fIX6EfMmIBaKdyzC58mg5s4fK7LEyWyuzh8qsqp63p-B1P0F4cpw6qoA4AlildA_l6eV_p_4B9QGiEA</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Rasheed, Naila</creator><creator>Ahmad, Ausaf</creator><creator>Pandey, Chandra Prakash</creator><creator>Chaturvedi, Rajnish Kumar</creator><creator>Lohani, Mohtashim</creator><creator>Palit, Gautam</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20100101</creationdate><title>Differential Response of Central Dopaminergic System in Acute and Chronic Unpredictable Stress Models in Rats</title><author>Rasheed, Naila ; 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Involvement of D
1
receptor was also examined during AS and CUS using A 68930, a D
1
selective agonist. Rats were exposed to AS (single immobilization for 150 min) and CUS (two different stressors for 7 days). AS significantly decreased the DA levels in the striatum and hippocampus, and A 68930 pretreatment significantly reverted these changes. However, in the frontal cortex significantly increased DA levels were remain unchanged following A 68930. CUS led to a decrease of DA levels in the frontal cortex, striatum and hippocampus, which were normalized by A 68930. Saturation radioligand binding assays revealed a significant decrease in the number of D
1
-like receptors in the frontal cortex during CUS, which were further decreased by A 68930 pretreatment. However, in the striatum and hippocampus, A 68930 pretreatment reduced the CUS induced increase in the number of D
1
-like receptors. No significant changes were observed in the amygdala and orbito-frontal cortex during AS and CUS, while D
2
-like receptors were unchanged in all the brain regions studied. Locomotor activity was significantly decreased in both the stress models, A 68930 pretreatment significantly increased stereotypic counts and horizontal activity. Thus, present investigation provide insights into the differential regional response of dopaminergic system during AS and CUS. Further, neurochemical and behavioral effects of D
1
agonist pretreatment suggest specific modulatory role of D
1
receptor under such stressful episodes.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>19568932</pmid><doi>10.1007/s11064-009-0026-5</doi><tpages>11</tpages></addata></record> |
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| subjects | Acute Disease Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Chromatography, High Pressure Liquid Chronic Disease Disease Models, Animal Dopamine - metabolism Locomotion Male Neurochemistry Neurology Neurosciences Original Paper Rats Rats, Sprague-Dawley Receptors, Dopamine - metabolism Stress, Physiological |
| title | Differential Response of Central Dopaminergic System in Acute and Chronic Unpredictable Stress Models in Rats |
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