Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis

Background:Chronic lung infection with Pseudomonas aeruginosa is the most severe complication for patients with cystic fibrosis (CF). This infection is characterised by endobronchial mucoid biofilms surrounded by numerous polymorphonuclear leucocytes (PMNs). The mucoid phenotype offers protection ag...

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Veröffentlicht in:	Thorax 2010-01, Vol.65 (1), p.57-62
Hauptverfasser:	Kolpen, M, Hansen, C R, Bjarnsholt, T, Moser, C, Christensen, L D, van Gennip, M, Ciofu, O, Mandsberg, L, Kharazmi, A, Döring, G, Givskov, M, Høiby, N, Jensen, P Ø
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibiotics Bacteria Biofilms Biological and medical sciences Bronchi - immunology Bronchi - microbiology Cardiology. Vascular system Chronic Disease Cystic fibrosis Cystic Fibrosis - microbiology Errors of metabolism Female Humans Infections Leukocytes Lungs Male Medical sciences Metabolic diseases Middle Aged Miscellaneous hereditary metabolic disorders NADPH Oxidases - metabolism Neutrophils - metabolism Neutrophils - microbiology Oxygen Consumption - physiology Phagocytosis Pneumology Pseudomonas aeruginosa Pseudomonas Infections - microbiology Reactive Oxygen Species - metabolism Respiration Respiratory Burst - physiology Sputum - cytology Sputum - microbiology Statistical analysis Superoxides - metabolism Young Adult
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