Protein kinase G type Ialpha activity in human ovarian cancer cells significantly contributes to enhanced Src activation and DNA synthesis/cell proliferation

Previously, we showed that basal activity of nitric oxide (NO)/cyclic GMP (cGMP)/protein kinase G (PKG) signaling pathway protects against spontaneous apoptosis and confers resistance to cisplatin-induced apoptosis in human ovarian cancer cells. The present study determines whether basal PKG kinase...

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Veröffentlicht in:	Molecular cancer research 2010-04, Vol.8 (4), p.578-591
Hauptverfasser:	Leung, Elaine L, Wong, Janica C, Johlfs, Mary G, Tsang, Benjamin K, Fiscus, Ronald R
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma - enzymology Carcinoma - genetics Cell Line, Tumor Cell Proliferation Cyclic GMP - metabolism Cyclic GMP-Dependent Protein Kinase Type I Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic GMP-Dependent Protein Kinases - genetics Cyclic GMP-Dependent Protein Kinases - metabolism DNA Replication - genetics Dose-Response Relationship, Drug Enzyme Activation - genetics Enzyme Inhibitors - pharmacology Epidermal Growth Factor - pharmacology Female Gene Expression Regulation, Enzymologic - genetics Gene Expression Regulation, Neoplastic - genetics Humans Nitric Oxide - metabolism Ovarian Neoplasms - enzymology Ovarian Neoplasms - genetics Phosphorylation Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism RNA Interference src-Family Kinases
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